以双(三羟甲基)丙烷与氯甲酸乙酯为原料制备双六元环状碳酸酯(BTB),并以其为交联剂制备聚三亚甲基碳酸酯/聚己内酯(PTMC/PCL)三维网络聚合物,考察BTB的交联效果;以疏棉状嗜热丝孢菌脂肪酶为降解介质,研究PTMC/PCL三维网络聚合物的体外酶解性能。结果表明:BTB可有效促使PTMC或PCL发生交联反应,得到性能良好的三维网络聚合物,且PCL三维网络聚合物的酶解明显快于PTMC三维网络聚合物。
Bis(trimethylene carbonate) was synthesized from di(trimethylolpropane) and ethyl chloroformate to be used as crosslinker to form stable polymeric networks.The enzymatic degradation behavior of the obtained networks was investigated in lipase from Thermomyces lanuginosus at 37℃.The results showed that BTB had high reactivity and efficiency to crosslink poly (trimethylene carbonate) and poly(ε-caprolactone) and formed stable networks.Due to the preferred cleavage of ester bonds,the enzymatic degradation rate of poly(ε-caprolactone) networks was much faster than that of poly (trimethylene carbonate) networks in lipase.
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基金资助
“十三五”国家重点研发计划(2016YFC1000902);国家自然科学基金(51503093);沈阳市科技攻关项目(F16-205-1-37);辽宁省博士科研启动基金(201501116);辽宁省自然科学基金(20170540491)
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