采用乳化法制备以吲哚美辛为疏水药物模型、聚己内酯-聚乙二醇嵌段共聚物(mPCL-PEG-PCL)为载体,聚乙烯醇(PVA)为乳化剂的载药纳米粒子。将制得的吲哚美辛纳米颗粒与PVA共混制备10%(wt,质量分数)纺丝溶液,通过静电纺丝法制备具有缓释性能的吲哚美辛纳米粒/PVA纳米纤维膜。可观察到所制得的纳米纤维膜表面覆有纳米颗粒;且在37℃缓冲溶液中120h仍具有药物释放性能,药物累积释放量达到78%。吲哚美辛纳米粒/PVA纳米纤维膜在药物缓释领域具有较好的应用前景。
Indomethacin used as hydrophobic drug model,polycaprolactone-polyvinyl alcohol (mPCL-PEG-PCL) block copolymer as carrier and PVA as emulsifier,drug-loaded nanoparticles were prepared with emulsification method.Then the nanoparticles were blended with PVA solution to prepare 10wt% electrospinning solution,which was electrospan to prepare good slow-release indomethacin-loaded nanoparticle/PVA nanofibers.The results showed that the nanofiber diameter was around 500nm and the fiber was covered with nanoparticles.The fiber maintained the original functional groups of polymer nanoparticles and PVA.The thermal stability of fibers was mainly unchanged compared with that of blank samples.Meanwhile,after 120h sustained-release of nanofibers in PBS buffer solution,the cumulative release of fibers was able to reach 78%.The composite nanofibers may have a good potential market in the drug-loaded material field.
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基金资助
江苏高校优势学科建设工程资助项目(苏政办发[2010]118号);2018年度江苏省研究生科研创新计划(KYCX18-1817)
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