化工新型材料

化工新型材料 ›› 2018, Vol. 46 ›› Issue (3) : 152-155.

科学研究

PDLLA-g-NVP纤维膜材料的体外降解性能研究

作者信息 +

Study on the in vitro degradation of PDLLA-g-NVP fiber film

Wang Jingxia, Chen Yuheng, Ni Maojun, Chen Zhuping, Liu Siyang, Peng Chaorong

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文章历史 +

Received		Published
2016-11-15		2018-03-20
Issue Date	Revised Date
2018-04-09	2016-11-15

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摘要

利用辐射接枝技术制得聚乳酸(消旋,PDLLA)接枝N-乙烯基吡咯烷酮(NVP)(PDLLA-g-NVP)材料,并通过静电纺丝制备改性纤维膜,并对PDLLA-g-NVP进行了测试。研究结果表明:10%接枝率的PDLLA-g-NVP在降解90d时,纤维表面呈蜂窝状,纤维出现断裂,具有较好的亲水性,膜纤维平均直径为1.270μm,失重率为41.2%,在临床医疗领域具有较好的应用前景。

Abstract

Poly (lactic acid) grafting N-vinyl pyrrolidone (PDLLA-g-NVP) were prepared by gamma irradiation and electrospinning technology.The degradation behavior of PDLLA-g-NVP was studied in phosphate-buffered saline (PBS,pH 7 4±0 1) at 37℃.A series of analyses and characterizations (including morphologic changes,loss weight,DSC,FT-IR-ATR and ¹H-NMR) were conducted to the nanofibrous film after degradation and the results showed that the addition of NVP increased the degradation rate of PDLLA-g-NVP fiber film.SEM photos showed that the surface of grafting film with 10% and 15% grafting ratio were compact and no hole,and the fibers' surfaces appeared a large number of cellular structures and turned to break after 90 days degradation.The average diameter of fiber was 1.270μm,and the mass lose was 41.2%.This method broaden the application fields of material and showed the promising in clinical areas.

关键词

聚乳酸 / 降解 / N-乙烯基吡咯烷酮 / 纳米纤维膜 / 复合材料

Key words

polylatic acid / degradation / N-vinyl pyrrolidone / fiber film / composite

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PDLLA-g-NVP纤维膜材料的体外降解性能研究[J]. 化工新型材料, 2018, 46(3): 152-155 DOI:

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参考文献

原文顺序 | 出版日期 | 本文引用

[1] Urayama H,Kanamori T,Kimura Y,et al.Properties and biodegradability of polymer blends of poly(L-lactide)s with different optical purity of the lactate units[J].Macromolecular Materials and Engineering,2002,287(2):116-121.
[2] Jeevitha D,Amarnath K.Chitosan/PLA nanoparticles as a novel carrier for the delivery of anthraquinone:synthesis,characterization and in vitro cytotoxicity evaluation[J].Colloids and Surfaces B,Biointerfaces,2013,101:126-134.
[3] Novikova L N,Novikov L N,Kellerth J O.Biopolymers and biodegradable smart implants for tissue regeneration after spinal cord injury[J].Current Opinion in Neurology,2003,16(6):711-715.
[4] Kao C T,Lin C C,Chen Y W,et al.Poly(dopamine) coating of 3D printed poly(lactic acid) scaffolds for bone tissue engineering[J].Materials Science and Engineering(C),2015,56:165-173.
[5] Serra T,Ortiz-Hernandez M,Engel E,et al.Relevance of PEG in PLA-based blends for tissue engineering 3D-printed scaffolds[J].Materials Science and Engineering(C),2014,38:55-62.
[6] Peng C,Chen H,Wang J,et al.Controlled degradation of polylactic acid grafting N-vinyl pyrrolidone induced by gamma ray radiation[J].Journal of Applied Polymer Science,2013,130(1):704-709.
[7] 陈屿恒,彭朝荣,陈竹平,等.聚乳酸膜辐照接枝PVP的表面性能及细胞毒性[J].精细化工,2014,31(4):418-421.
[8] Armentano I,Bitinis N,Fortunati E,et al.Multifunctional nanostructured PLA materials for packaging and tissue engineering[J].Progress in Polymer Science,2013,38(10/11):1720-1747.
[9] Peg oretti A,Fambri L.In vitro degradation of poly(L-lactic acid) fibers produced by melt spinning,migliaresi C[J].Journal of Applied Polymer Science,1997,64:213-223.
[10] 刘磊,吴若峰.聚乳酸类材料的水解特征[J].合成材料老化与应用,2006,35(1):44-48.
[11] Hakkarainen M,Albertsson A C,Karlsson S,et al.Weight losses and molecular weight changes correlated with the evolution of hydroxyacids in simulated in vivo degradation of homo and co polymers of PLA[J].Polymer Degradation and Stability,1996,52(3):283-291.
[12] 彭朝荣,陈浩,王静霞,等.辐射法制备聚-L-乳酸/N-乙烯基吡咯烷酮接枝共聚物及其性能研究[J].中国核科学技术进展报告,2009,1(8):51-55.
[13] Chen Hao,Peng Chaorong,Yao Yongyi,et al.Preparation and characterization of poly(L-lactide) membranes prepared by c-radiation-induced grafting of N-vinyl pyrrolidone[J].Journal of Applied Polymer Science,2009,114(5):3152-3157.
[14] Lei Xiong,Hong Weijiang,Di Zhenwang,et al.Synthesis,characterization and degradation of poly(DL-lactide)-block-polyvinylpyrrolidone-block-poly(DL-lactide) copolymers[J].Journal Polymer Research,2009,16:191-197.