采用环氧丙烷改性瓜尔胶制备得到羟丙基瓜尔胶,再将其与聚氨酯复合制备微球,并对复合微球的性能进行了研究。结果表明:羟丙基瓜尔胶含量在0.1%～0.3%时,复合微球球形较好;溶胀度随着羟丙基瓜尔胶含量的增加而增加;扫描电镜结果显示,复合微球表面有孔隙,内部呈半中空状态;复合微球的降解速率在碱性环境下较快,酸性环境下较慢;羟丙基瓜尔胶含量越高,药物释放速率越快。
Hydroxypropyl guar gum(HPG) was prepared by propylene oxide and guar gum.HPG/PU composite microspheres prepared by HPG and polyurethane (PU) were studied.Study showed that the sphericity of composite microspheres were better when HPG content was between 0.1%～0.3%.The content of HPG was more,swelling degree was increased.SEM photograph showed that the composite microsphere surface had holes,its interior were half hollow.The degradation rate of composite microspheres in alkaline environment was faster and slower in acidic condition.HPG content was more,the rate of drug release was faster.
[1] 吴亚,赵攀,李凡,等.改性瓜尔压裂液的制备及性能研究[J].应用化工,2013,25(2):228-230.
[2] Beer M,Wood P J,Weisz J.Carbohydrate polymers[J].Journal of Polymer Research,1999,39(1):377-380.
[3] 王承学,黄桂华.羟丙基瓜尔胶的合成与表征[J].精细石油化工,2008,25(3):59-62.
[4] 王全杰,王小海,张玉洲.水性聚氨酯的合成及在弹力皮革上的应用[J].西部皮革,2011,33(14):33-35.
[5] Ma X Y,Zhang W D.Effects of flower-like ZnO nanowhiskers on the mechanical,thermal and antibacterial properties of waterborne polyurethane[J].Polymer Degradation and Stability,2009,94(7):1103-1109.
[6] Boretos J W,Pierce W S.Segmented polyurethane:a new elastomer for biomedical applications[J].Science,1976,15(4):1481-1482.
[7] 邱光美,徐静,申妍婷,等.聚氨酯/淀粉复合微球的制备及药物释放性能研究[J].化工新型材料,2011,39(10):88-90.
[8] 强琳,袁林江,丁擎.缓冲液对微生物燃料电池产电性能影响研究[J].环境科学,2011,32(5):1524-1528.
[9] 刘丰印.紫外分光光度法测定四环素片的含量[J].河北医学,2003,9(4):376-377.
基金资助
国家自然科学基金(21401151)
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