针对传统敷料力学性能不足和药物释放单一的问题,以L-赖氨酸为扩链剂,构建了基于聚己内酯的改性聚氨酯(mPU)多功能载药平台,用于负载不同性质的药物。膜拉伸强度15.8MPa,断裂伸长率530%,兼具高强高韧;表面疏水,水蒸气透过率为2.25g/(m2·d),实现“外阻微生物、内排湿气”屏障功能。差异化释药模式显示:水溶性VB1快速释放,适用于炎症早期;脂溶性VD3缓释,支持组织修复;无显著细胞毒性。该mPU敷料性能优良,为新一代伤口敷料研发提供了可行策略。
To address the insufficient mechanical properties and single drug-release behavior of traditional dressings,L-lysine was used as a chain extender to develop a polycaprolactone-based modified polyurethane (mPU) multifunctional drug delivery platform for the loading of drugs with different properties.The mPU film achieved a tensile strength of 15.8MPa and an elongation at break of 530%,demonstrating a combination of high strength and high toughness.The surface was hydrophobic,with a water vapor transmission rate of 2.25g/(m2·d),enabling a dual-function barrier that resisted external microorganisms while allowing internal moisture permeability.The differential drug-release pattern showed that water-soluble VB1 was rapidly released,making it suitable for the early stage of inflammatory.The lipid-soluble VD3 exhibited sustained release to facilitate tissue repair.No significant cytotoxicity was observed.This mPU-based dressing presented excellent performance and provided a promising approach for the development of next-generation wound care materials.
[1] Boateng J S,Matthews K H,Stevens H N,et al.Wound healing dressings and drug delivery systems:a review[J].Journal of Pharmaceutical Sciences,2008,97(8):2892-2923.
[2] Guo B,Ma P X.Synthetic biodegradable functional polymers for tissue engineering:a brief review[J].Science China Chemistry,2014,57(4):490-500.
[3] Gorna K,Gogolewski S.Preparation,degradation,and calcification of polyurethanes with hydrophilic blocks[J].Journal of Biomedical Materials Research,2002,60(4):592-606.
[4] Han J,Chen B,Ye L,et al.Synthesis and characterization of biodegradable polyurethane based on L-lysine diisocyanate and poly (ε-caprolactone)[J].Frontiers of Materials Science,2011,5(1):22-32.
[5] Chen H,Jiang X,He L,et al.Novel biocompatible waterborne polyurethane using L-lysine as an extender[J].Journal of Applied Polymer Science,2002,84(13):2474-2480.
[6] Saghazadeh S,Rinoldi C,Schot M,et al.Drug delivery systems and materials for wound healing applications[J].Advanced Drug Delivery Reviews,2018,127:138-166.
[7] Arnold M,Barbul A.Nutrition and wound healing[J].Plastic and Reconstructive Surgery,2006,117(7S):42S-58S.
[8] Schauber J,Gallo R L.Antimicrobial peptides and the skin immune defense system[J].Journal of Allergy and Clinical Immunology,2008,122(2):261-266.
[9] Bikle D D.Vitamin D metabolism and function in the skin[J].Molecular and Cellular Endocrinology,2011,347(1-2):80-89.
[10] Lei X,Yao Y,Sun F,et al.Ultrasound-driven piezoelectric strategy and performance:polyurethane-based functioning networks in actuating bone repair[J].Advanced Functional Materials,2025,35(41):2502684.
[11] Wang L,Heuchel M,Fang L,et al.Influence of a polyester coating of magnetic nanoparticles on magnetic heating behavior of shape-memory polymer-based composites[J].Journal of Applied Biomaterials & Functional Materials,2012,10(3):203-209.
[12] Guelcher Scott A,Srinivasan Abiraman,Dumas Jerald E,et al.Synthesis,mechanical properties,biocompatibility,and biodegradation of polyurethane networks from lysine polyisocyanates[J].Biomaterials,2008,29:1762-1775.
[13] Fang W Sun F,Tang J,et al.Porous electroactive and biodegradable polyurethane membrane through self-doping organogel[J].Macromolecular Rapid Communications,2021,42(12):2100125.
[14] Hao H,Shao J,Deng Y,et al.Synthesis and characterization of biodegradable lysine-based waterborne polyurethane for soft tissue engineering applications[J].Biomaterials Science,2016,4(11):1682-1690.
[15] Choi J H,Woo J J,Kim I.Sustainable polycaprolactone polyol-based thermoplastic poly(ester ester) elastomers showing superior mechanical properties and biodegradability[J].Polymers,2023,15(15):3209.
[16] Puszka A,Ukleja-Sokołowska N,et al.Influence of the type of soft segment on the selected properties of polyurethane materials for biomedical applications[J].Materials,2024,17(4):840.
[17] Tang Y,Lan X,Liang C,et al.Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement[J].Scientific Reports,2016,6:24788.
[18] Lonsdale D.A review of the biochemistry,metabolism and clinical benefits of thiamin(e) and its derivatives[J].Evidence-Based Complementary and Alternative Medicine,2006,3(1):49-59.
[19] 秦正杨,李玉宝,李吉东.基于电荷相互作用高效负载EGCG的明胶微球制备与性能研究[J].四川师范大学学报(自然科学版),2026,49(4):1-8.
基金资助
四川省国际科技创新合作项目(2024YFHZ0308)
PDF
(1239KB)
