以改性后的天然高分子羟丙基纤维素和普鲁兰多糖为成纤聚合物,静电纺丝制备了一种升温可卷曲的温度响应性双面纳米纤维。利用其升温弯曲特性,构建了基于纤维缠绕作用的新型水凝胶网络体系,从而得到了一种可注射天然高分子水凝胶。通过扫描电镜确认了水凝胶的溶胶-凝胶转变源于热诱导自卷曲纤维之间的紧密缠结和纤维之间疏水相互作用的协同作用。流变测试证明了该水凝胶具有与软骨近似的物理性能,并能在人体温度下形成稳定的凝胶结构。该水凝胶采用天然高分子制备、凝胶过程无化学反应是一种良好的仿生材料或支架材料,在生物医疗材料领域有良好的应用前景。
Using modified natural polymers hydroxypropyl cellulose and pullulan polysaccharide as fiber-forming polymers,a temperature-responsive double-sided nanofiber was prepared by electrospinning.Taking advantage of its heating-bending properties,a hydrogel network system based on filament entanglement was constructed,resulting in a novel natural polymer injectable hydrogel.The characterization results obtained by SEM demonstrated that the sol-gel transition of the hydrogel should stem from synergistic action of the tight entanglements between thermally-induced self-curling fibers and the hydrophobic interactions between the fibers.Rheological tests indicated that the hydrogel possessed physical properties approximating those of cartilage and formed a stable gel structure at body temperature.The hydrogel was a good bionic material or scaffold material prepared with natural polymer and no chemical reaction in the gelation process,which had good application prospects in the field of biomedical materials.
[1] Liang Y P,He J H,Guo B L.Functional hydrogels as wound dressing to enhance wound healing[J].ACS Nano,2021,15(8):12687-12722.
[2] 王瑞环,贾伟娜,纪宽,等.可注射水凝胶在伤口敷料中的研究进展[J].化学通报,2024,87(2):157-163.
[3] Chang B,Ahuja N,Ma C,et al.Injectable scaffolds:preparation and application in dental and craniofacial regeneration[J].Materials Science and Engineering:R:Reports,2017,111:1-26.
[4] Karoyo A H,Lee L D.Wilson.A review on the design and hydration properties of natural polymer-based hydrogels[J].Materials,2021,14(5):1095.
[5] 刘萌萌,秋列维,万智卫,等.自愈水凝胶的设计原理及应用[J].化工进展,2024,43(3):1350-1362.
[6] Jiang T M,Yang T,Bao Q,et al.Construction of tissue-customized hydrogels from cross-linkable materials for effective tissue regeneration[J].Journal of Materials Chemistry B,2022,10(25):4741-4758.
[7] Lin H,Yin C L,Mo A C,et al.Applications of hydrogel with special physical properties in bone and cartilage regeneration[J].Materials,2021,14(1):235.
[8] Yang B,Song L,Jiang Y H,et al.Injectable adhesive self-healing multicross-linked double-network hydrogel facilitates full-thickness skin wound healing[J].ACS Applied Materials & Interfaces,2020,12(52):57782-57797.
[9] Aldana A A,Houben S,Moroni L,et al.Trends in double networks as bioprintable and injectable hydrogel scaffolds for tissue regeneration[J].ACS Biomaterials Science & Engineering,2021,7(9):4077-4101.
[10] Chang B,Ahuja N,Ma C,et al.Injectable scaffolds:preparation and application in dental and craniofacial regeneration[J].Materials Science and Engineering:R:Reports,2017,111:1-26.
[11] 邓静倩,侯丹丹,祁丽亚,等.高分子微球在三维细胞培养领域的应用进展[J].化工新型材料,2023,51(S2):155-160.
[12] 王欣怡,谢宪瑞,陈玉杰,等.软组织和硬组织再生过程中的电纺纳米纤维支架[J].中国组织工程研究,2024,28(3):426-432.
[13] 黄贺东,蒲浩,樊军伟,等.醋酸纤维素/聚丙烯腈纳米纤维薄膜的制备与性能表征[J].化工新型材料,2024,52(9):99-103.
[14] 王中义,孙金声,黄贤斌,等.LCST型温度敏感聚合物的研究及其在钻井液领域的应用进展[J].精细化工,2024,DOI:10.13550/j.jxhg.20230790.
[15] 赵琦,袁凤来,陈明清,等.载有左氧氟沙星的普鲁兰多糖薄膜用于伤口敷料[J].功能高分子学报,2024,37(2):138-147.
[16] Chen G Y,Xu Y,Yu D G,et al.Structure-tunable Janus fibers fabricated using spinnerets with varying port angles[J].Chemical Communications,2015,51(22):4623-4626.
[17] 张锦中,刘晓云,杨健茂,等.温度响应性双面纳米纤维的制备和性能[J].材料研究学报,2023,37(4):248-256.
[18] Zhang J Z,Zha X L,Liu G X,et al.Injectable extracellular matrix-mimetic hydrogel based on electrospun Janus fibers[J].Materials Horizons,2024,11(8):1944-1956.
[19] Yang J A,Yeom J,Hwang B W,et al.In situ-forming injectable hydrogels for regenerative medicine[J].Progress in Polymer Science,2014,39(12):1973-1986.
[20] 钟启明,张佳雨,郭城,等.海藻酸钠水凝胶3D打印效果和流变特征及其相关性分析[J].食品工业科技,2023,44(23):21-28.
[21] Wang T,Gunasekaran S.State of water in chitosan-PVA hydrogel[J].Journal of Applied Polymer Science,2006,101(5):3227-3232.
[22] 董梦真,王鹏粼,管洁,等.软骨修复用聚乙烯醇/壳聚糖复合水凝胶的制备及体外性能研究[J].化工新型材料,2024,52(6):228-233.
基金资助
国家自然科学基金(51503033)
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