卤胺化合物因其具有广谱抗菌性、快速杀菌且不产生耐药性、可再生性、长期稳定性以及对人类和环境的安全性而受到广泛关注。而目前国内外学者对于卤胺类抗菌剂的研究主要集中在抗菌纺织品领域,在医用领域的研究不足。主要综述了卤胺类抗菌剂及其在生物医用领域的研究进展。根据卤胺类抗菌医用材料的化学结构及其制备方法,详细介绍了小分子卤胺、合成大分子卤胺及天然大分子卤胺的合成,及其在医用抗菌领域的研究进展,并对卤胺类化合物未来在生物医用领域的主要研究方向进行了展望。
N-halamine compounds have drawn increasing research interest due to their unique properties,such as broad-spectrum antibacterial properties,fast sterilization without drug resistance,regenerability,long-term stability and safety to human beings and the environment.At present,domestic and foreign scholars mainly focus on the research of N-halamine antibacterial agents in the field of antibacterial textiles,and the research in the medical field is insufficient.This paper reviewed the recent progress of N-halamine antibacterial agents and their applications in biomedical field.According to the chemical structure and preparation methods of N-halamine antibacterial medical materials,the synthesis of small molecule N-halamines,macromolecular N-halamines and natural macromolecular N-halamines,as well as the research progress in the field of medical antibacterial were introduced in detail.Furthermore,the main future research directions of N-halamines in the biomedical field were also prospected.
[1] Oliveira A,Simōes S,Ascenso A,et al.Therapeutic advances in wound healing[J].Dermatol.Treat,2020,1-21.
[2] 乐志文,凌新龙,岳新霞.抗菌材料的研究现状及发展趋势[J].成都纺织高等专科学校学报,2016,33(2):58-66.
[3] 王国锋,李菲,李利娜,等.纳米载银医用TPU抗菌材料的制备及其性能研究[J].辽宁化工,2020,49(9):1059-1062.
[4] 陶寿晨,徐吉林,罗军明.含铜医用金属抗菌材料的研究现状[J].特种铸造及有色合金,2019,39(11):1182-1186.
[5] 张耀成,吴勇振,李阳,等.双季铵盐改性医用PVC抗菌材料[J].中国塑料,2021,35(7):53-57.
[6] 张帆,高树珍,杨晴,等.卤胺类抗菌剂的研究进展[J].黑龙江纺织,2019(2):7-10.
[7] Chen H,Li S,Wu M,et al.Membrane-anchoring photosensitizer with aggregation-induced emission characteristics for combating multidrug-resistant bacteria[J].Angewandte Chemie International Edition,2020,59:632-636.
[8] Sathit M,Saengrawee T,Pawinee S,et al.Silver nanoparticles enhance antimicrobial efficacy of antibiotics and restore that efficacy against the melioidosis pathogen[J].Antibiotics,2021,10(7):839.
[9] Wang Y L,Du J,Guo H Y,et al.The antibacterial activity and mechanism of polyurethane coating with quaternary ammonium salt[J].Journal of Polymer Research,2022,29(2):47.
[10] Cao S J,Xu G,Li Q J,et al.Double crosslinking chitosan sponge with antibacterial and hemostatic properties for accelerating wound repair[J].Composites Part B:Engineering,2022,234:109746.
[11] 辛本凯,王会岩.抗菌肽在抗菌材料中的研究进展[J].吉林医药学院学报,2021,42(1):53-55.
[12] Kang J,Han J S,Gao Y Y,et al.Unexpected enhancement in antibacterial activity of N-halamine polymers from spheres to fibers[J].ACS Applied Materials & Interfaces,2015,7(31):17516-17526.
[13] Kaur R,Liu S.Antibacterial surface design-contact kill[J].Progress in Surface Science,2016,91(3):136-153.
[14] Cervantes G,Martha Y,Li H,et al.N-halamine-decorated electrospun polyacrylonitrile nanofibrous membranes:characterization and antimicrobial properties[J].Reactive and Functional Polymers,2021,168:105058.
[15] Zheng Y X,Pan N Y,Liu Y,et al.Novel porous chitosan/N-halamine structure with efficient antibacterial and hemostatic properties[J].Carbohydrate Polymers,2021,253:117205.
[16] Tang X,Xu H D,Shi Y Q,et al.Porous antimicrobial starch particles containing N-halamine functional groups[J].Carbohydrate Polymers,2020,229:115546.
[17] Liu Y,He Q H,Li R,et al.Durable antimicrobial cotton fabrics treated with a novel N-halamine compound[J].Fibers and Polymers,2016,17(12):2035-2040.
[18] Wu S,Xu J,Zou L,et al.Long-lasting renewable antibacterial porous polymeric coatings enable titanium biomaterials to prevent and treat peri-implant infection[J].Nat Commun,2021,12:3303.
[19] Chai D X,Liu W X,Hao X F,et al.Mussel-inspired synthesis of magnetic N-halamine nanoparticles for antibacterial recycling[J].Colloid and Interface Science Communications,2020,39:100320.
[20] Gao Y,Song N,Liu W,et al.Construction of antibacterial N-halamine polymer nanomaterials capable of bacterial membrane disruption for efficient anti-infective wound therapy[J].Macromolecular Bioscience,2019,19:1800453.
[21] Wang F,Liu M,Ding R D,et al.Rechargeable antibacterial polysulfonamide-based N-halamine nanofibrous membranes for bioprotective applications[J].ACS Applied Bio Materials,2019,2(8):3668-3677.
[22] Kang B,Li Y D,Liang J,et al.Novel PVDF hollow fiber ultrafiltration membranes with antibacterial and antifouling properties by embedding N-halamine functionalized multi-walled carbon nanotubes (MWNTs)[J].RSC Advances,2016,6:1710-1721.
[23] 巫丹平.抗菌纤维素纤维的制备与研究进展[J].纺织科学研究,2019(2):76-77.
[24] Du H S,Parit M,Liu K,et al.Engineering cellulose nanopaper with water resistant,antibacterial,and improved barrier properties by impregnation of chitosan and the followed halogenation[J].Carbohydrate Polymers,2021,270:118372.
[25] Zeng J B,He Y Y,Li S L,et al.Chitin whiskers:an overview[J].Biomacromolecules,2012,13(1):1-11.
[26] Qu X,Liu H,Zhang C C,et al.Electrofabrication of functional materials:chloramine-based antimicrobial film for infectious wound treatment[J].Acta Biomaterialia,2018,73:190-203.
[27] 张通,蔡金池,袁志发,等.基于透明质酸的复合水凝胶修复骨关节炎软骨损伤:应用与机制[J].中国工程研究,2022,26(4):617-625.
[28] 凌志强,杜卫刚,李东.透明质酸衍生物的研究进展[J].云南化工,2021,48(11):16-17.
[29] Hauck S,Zager P,Halfter N,et al.Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity[J].Bioactive Materials,2021,6(12):4342-4359.
[30] Chen W J,Zhu Y N,Zhang Z,et al.Engineering a multifunctional N-halamine-based antibacterial hydrogel using a super-convenient strategy for infected skin defect therapy[J].Chemical Engineering Journal,2020,379:122238.
基金资助
国家自然科学基金(21772080);甘肃省重点研发计划(21YF5FA104)
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