化工新型材料

化工新型材料 ›› 2023, Vol. 51 ›› Issue (11) : 138-141. DOI: 10.19817/j.cnki.issn1006-3536.2023.11.024

新材料与新技术

二氧化硅/壳聚糖复合微球的制备及性能

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Preparation and properties of silica/chitosan composite microspheres

Jin Yuzhu, Liu Ying, Liu Taiyou, Zhang Jianxun

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Received		Published
2022-07-11		2023-11-20
Issue Date	Revised Date
2023-11-29	2022-07-11

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摘要

通过溶胶-凝胶法制备出3种不同粒径的SiO₂微球,利用扫描电镜分析了微球的粒径分布情况,SiO₂微球粒径分别在140nm、208nm、336nm左右,在一定范围内,硅球的粒径随正硅酸四乙酯(TEOS)/氨水的添加量增加而增大。选取粒径在336nm左右的SiO₂微球,使用硅烷偶联剂3-(2,3-环氧丙氧基)丙基三甲氧基硅烷(GPTMS)将壳聚糖(CS)接枝在SiO₂微球上,得到SiO₂@CS复合微球。通过红外光谱分析、X射线衍射等对微球进行了表征。接枝CS后对SiO₂微球的结晶特性没有影响,微球仍为无定形晶体。元素分析结果表明CS的接枝量为1.03%。使用振荡法进行抗菌测试,SiO₂@CS复合微球对金黄色葡萄球菌(S.aureus)和大肠杆菌(E.coil)的抑菌率分别为85.52%和47.14%,表明复合微球有一定的抗菌效果。

Abstract

Three SiO₂ microspheres with different particle sizes were prepared by sol-gel method.The particle size distribution of the microspheres was analyzed by scanning electron microscopy,and the particle size of SiO₂ microspheres was about 140nm,208nm and 336nm,respectively.Within a certain range,the particle size of the silicon microspheres increased with the addition of TEOS/ammonia.SiO₂ microspheres with a particle size of about 336 nm were selected,and the silane coupling agent 3-(2,3-epoxypropoxy)propyltrimethoxysilane (GPTMS) was used to graft chitosan (CS) onto SiO₂ microspheres to obtain SiO₂@CS composite microspheres.The microspheres are characterized by infrared spectroscopy and X-ray diffraction,etc.Grafting chitosan had no effect on the crystallization characteristics of SiO₂ microspheres,which were still amorphous crystals.The results of elemental analysis showed that the grafting amount of chitosan was 1.03%.The antibacterial test using the oscillation method indicated that the bacteriostatic rates of the SiO₂@CS composite microspheres against staphylococcus aureus (S.aureus) and colibacillusis (E.coil) were 85.52% and 47.14%,respectively,indicating that the composite microspheres had a certain antibacterial effect.

关键词

二氧化硅 / 壳聚糖 / 微球 / 抗菌材料

Key words

SiO₂ / chitosan / microspheres / antibacterial materials

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二氧化硅/壳聚糖复合微球的制备及性能[J]. 化工新型材料, 2023, 51(11): 138-141 DOI:10.19817/j.cnki.issn1006-3536.2023.11.024

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