A graphene oxide-based hydrogel was prepared for bacterial wound healing by hydrogen bonding reaction of quaternized N-haloamine modified graphene oxide with polyvinyl alcohol (PVA).The microscopic morphology and crystalline structure of the samples were characterized by scanning electron microscopy,X-ray diffraction,and Fourier-transform infrared spectroscopy,and their antibacterial properties were also tested.The results showed that the hydrogel had the characteristics of sterilization,good biocompatibility,low cytotoxicity,and could continuously release bactericidal ions,which was conducive to the recovery of wounds.Therefore,it had a wide application prospect.
[1] O'Connor N A,Syed A,Wong M,et al.Polydopamine antioxidant hydrogels for wound healing applications[J].Gels,2020,6(4):39.
[2] Blit P H,Al-Shehab M,Arno A,et al.Polysaccharide based hydrogels for the delivery of umbilical cord derived mesenchymal stem cells for cutaneous wound healing[J].Tissue Eng Regen M,2012,6:100-100.
[3] Kim M S,Shin K W,Kim W I,et al.Healing potential of O-2-hydrogels on a full-thickness excision cutaneous wound in diabetic mice[J].Tissue Eng Regen M,2012,6:97-97.
[4] Wong V W,Rustad K C,Galvez M G,et al.Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing[J].Tissue Eng Pt A,2011,178(5/6):631-644.
[5] Fan L H,Tan C,Wang L B,et al.Preparation,characterization and the effect of carboxymethylated chitosan-cellulose derivatives hydrogels on wound healing[J].Journal of Applied Polymer Science,2013,128(5):2789-2796.
[6] Tran N Q,Joung Y K,Lih E,et al.In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing[J].Biomacromolecules,2011,12(8):2872-2880.
[7] Bai R,Kang J,Simalou O,et al.Novel N-Br bond-containing N-halamine nanofibers with antibacterial activities[J].ACS Biomaterials Science & Engineering,2018,4(6):2193-2202.
[8] Xin Q,Shah H,Nawaz A,et al.Antibacterial carbon-based nanomaterials[J].Adv Mater,2019,31(45):1-15.
[9] Li Manna,Chen Zhaofeng,Sun Yu,et al.Preparation and antibacterial activity of graphene oxide/cuprous oxide/zinc oxide nanocomposite[J].Mater Res Express,2021,8(12):125003.
[10] Agnieszka Wanag,Paulina Rokicka,Ewelina Kusiak-Nejman,et al.Antibacterial properties of TiO2 modifified with reduced graphene oxide[J].Ecotoxicology and Environmental Safety,2018,147:788-793.
[11] Norahan M H,Mohadeseh P,Saeb M R,et al.Electroactive cardiac patch containing reduced graphene oxide with potential antibacterial properties[J].Materials Science & Engineering C-Materials for Biological Applications,2019,104:109921.
[12] Li L,Zhao N,Liu S.Versatile surface biofunctionalization of poly(ethylene terephthalate) by interpenetrating polymerization of a butynyl monomer followed by “Click Chemistry”[J].Polymer,2012,53(1):67-78.
[13] Pan N,Wang Y,Ren X,et al.Graphene oxide as a polymeric N-halamine carrier and release platform:highly-efficient,sustained-release antibacterial property and great storage stability[J].Materials Science and Engineering:C,2019,103:109877.
[14] Wang X,Hao X,Chang D,et al.Novel hydrophilic N-halamine polymer with enhanced antibacterial activity synthesized by inverse emulsion polymerization[J].Journal of Applied Polymer Science,2019,136(17):47419.
[15] Wu L,Li L,Fan M,et al.Strong and tough PVA/PAA hydrogel fiber with highly strain sensitivity enabled by coating MWCNTs[J].Composites Part A:Applied Science and Manufacturing,2020,138:106050.
[16] Wang X,Hao X,Chang D,et al.Novel hydrophilic N-halamine polymer with enhanced antibacterial activity synthesized by inverse emulsion polymerization[J].Journal of Applied Polymer Science,2019,136(17):56-59.
基金资助
吉林省教育厅基础研究基金项目(JJKH20210758KJ)
PDF
