通过甲基丙烯酸缩水甘油酯(GMA)对超支化聚缩水甘油醚(HPG)进行改性得到具有双键功能的大分子交联剂超支化丙烯酸甲酯聚甘油(HPG-MA)。HPG-MA作为大分子交联剂可与两性离子丙烯酰胺磺酸基甜菜碱(DMAAPS)进行自由基聚合形成交联的网络结构,制备出具有抗菌性和粘附性的HPG-MA/DMAAPS水凝胶。对HPG-MA/DMAAPS的水凝胶溶胀率、水蒸汽透过率、粘附性和抗菌性能进行测试。结果表明:所制两性离子质量分数为92％的水凝胶的溶胀率达到543％,并在达到溶胀平衡时仍能保持其形状;同时,其水蒸汽透过率为2129g/(m2·d),与纱布相比可以提供一个更保湿的环境;通过平板菌落计数法发现HPG-MA/DMAAPS水凝胶对金黄色葡萄球菌和大肠杆菌均具有良好的抑制作用。
Hyperbranched polyglycerol (HPG) was modified by GMA to obtain the macromolecular crosslinking agent HPG-MA with double bond function.HPG-MA as a macromolecular cross-linking agent polymerized with DMAAPS to form a cross-linked network structure,and then HPG-MA/DMAAPS hydrogels with antibacterial and adhesive properties were prepared through free radical polymerization.The hydrogel swelling rate,water vapor transmission rate,adhesion and antibacterial properties of HPG-MA/DMAAPS were tested.The results showed that the swelling rate of the prepared hydrogel with a zwitterion mass fraction of 92% reached to 543% and it still maintained its shape when achieving swelling balance.At the same time,its water vapor transmission rate was 2129g/(m2·d),which provided a more moisturizing environment compared with gauze.By the plate colony counting method,it was found that HPG-MA/DMAAPS hydrogel had good inhibitory effects against both Staphylococcus aureus and E.coli.
[1] 史韵琪,梁敏,耿天翼,等.会变形的水凝胶[J].大学化学,2020,35(4):10-18.
[2] Ying H,Zhang L F,Wu D,et al.Ionic strength-response hyperbranched polyglycerol/polyacrylic acid hydrogel for the reversible immobilization of enzyme and the synthesis of biodiesel[J].Energy Conversion and Management,2017,144:303-311.
[3] 胡杨,余小月,但卫华,等.胶原基水凝胶的制备、结构性能表征及其在生物医学中的应用[J].功能材料,2017,48(1):1038-1046.
[4] Zhao X.Multi-scale multi-mechanism design of tough hydrogels:building dissipation into stretchy networks[J].Soft Matter,2014,10:672.
[5] Liu X,Liu J,Lin S,et al.Hydrogel machines[J].Materials Today,2020,36:102-124.
[6] Hoffman A S.Hydrogels for biomedical applications[J].Advanced Drug Delivery Reviews,2002,54(1):3-12.
[7] Hong J,Shin Y,Kim S,et al.Complex tuning of physical properties of hyperbranched polyglycerol-based bioink for microfabrication of cell-laden hydrogels[J].Advanced Functional Materials,2019,29:1808750.
[8] Pedron S,Pritchard A M,Vincil G A,et al.Patterning three-dimensional hydrogel microenvironments using hyperbranched polyglycerols for independent control of mesh size and stiffness[J].Biomacromolecules,2017,18:1393-1400.
[9] Dadkhah M,Shamlooei H,Mohammadifar E,et al.Synthesis of hyperbranched polyglycerols using ascorbic acid as an activator[J].RSC Advance,2018,8:217-221.
[10] Mohammadifar E,Bodaghi A,Dadkhahtehrani A,et al.Green synthesis of hyperbranched polyglycerol at room temperature[J].ACS Macro Letters,2017,6:35-40.
[11] Lowe A B,McCormick C L.Synthesis and solution properties of zwitterionic polymers[J].Chemical Reviews,2002,102(11):4177-4189.
[12] 胡冠南.两性离子水凝胶微球的可控制备与应用[D].天津:天津大学,2018.
[13] Yang W,Xue H,Li W,et al.Pursuing “zero” protein adsorption of poly(carboxybetaine) from undiluted blood serum and plasma[J].Langmuir,2009,25(19):11911-11916.
[14] Nikam S P,Chen P,Nettleton K,et al.Zwitterion surface-functionalized thermoplastic polyurethane for antifouling catheter applications[J].Biomacromolecules,2020,21:2714-2725.
[15] 林殷雷.新型自愈合高分子水凝胶的设计、制备与性能研究[D].广东:华南理工大学,2014.
[16] Cao Z,Zhang L,Jiang S.Superhydrophilic zwitterionic polymers stabilize liposomes[J].Langmuir,2012,28(31):11625-11632.
[17] Peng X,Liu H,Yin Q,et al.A zwitterionic gel electrolyte for efficient solid-state supercapacitors[J].Nature Communications,2016,7:11782.
[18] Stashak T S,Farstvedt E,Othic A.Update on wound dressings:indications and best use[J].Clinical Techniques in Equine Practice,2004,3(2):148-163.
[19] Wu A,Gao Y,Zheng L.Zwitterionic amphiphiles:their aggregation behavior and applications[J].Green Chemistry,2019,21:4290-4312.
[20] Sunder A,Krämer M,Hanselmann R,et al.Molecular nanocapsules based on amphiphilic hyperbranched polyglycerols[J].Angewandte Chemie International Edition,1999,38:3552-3555.
[21] Oudshoorn M H,Rissmann R,Bouwstra J A,et al.Synthesis and characterization of hyperbranched polyglycerol hydrogels[J].Biomaterials,2006,27:5471-5479.
[22] 张良良.具有良好力学性能可用于伤口敷料的聚氨酯——聚丙烯酰胺水凝胶的制备与性能[D].合肥:安徽大学,2018.
基金资助
青海省科技厅项目(2020-ZJ-729)
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