将硫酸水解得到的纳晶纤维素(NCC)和壳聚糖(CS)溶液通过均匀共混、冷冻干燥制备了结构良好、性能优异的CS/NCC多孔复合膜,通过物理吸附卤胺抗菌剂,制备的多孔膜具有高效抗菌活性,可快速杀死大肠杆菌和金黄色葡萄球菌。利用万能试验机和扫描电镜,探究了CS和NCC不同比例对多孔膜的结构性能的影响,并探究了二者不同比例对水蒸汽透过率、孔隙率和表面密度的影响。
The nanocrystalline cellulose (NCC) hydrolyzed by sulfuric acid and chitosan (CS) solution were processed through homogenization and freeze-drying to obtain a porous NCC/CS film.The porous film adsorbed with antibacterial agent possessed a high antibacterial activity,which was able to kill S.aureus (ATCC 6538) and E.coli (ATCC 8099) quickly.The effects of different proportions of CS and NCC on the structure and properties of the porous film were investigated by using universal materials tester and scanning electron microscope.Then the influence of their various proportions on water vapor transmittance,porosity and surface density were also studied.
[1] Zhang Y,Yin M,Lin X,et al.Functional nanocomposite aerogels based on nanocrystalline cellulose for selective oil/water separation and antibacterial applications[J].Chemical Engineering Journal,2019,371:306-313.
[2] Zainuddin N,Ahmad I,Zulfakar M H,et al.Cetyltrimethylammonium bromide-nanocrystalline cellulose (CTAB-NCC) based microemulsions for enhancement of topical delivery of curcumin[J].Carbohydrate Polymers,2021,254:117401.
[3] Fardioui M,Meftah Kadmiri I,Qaiss A E K,et al.Bio-active nanocomposite films based on nanocrystalline cellulose reinforced styrylquinoxalin-grafted-chitosan:antibacterial and mechanical properties[J].International Journal of Biological Macromolecules,2018,114:733-740.
[4] Luo H,Cha R,Li J,et al.Advances in tissue engineering of nanocellulose-based scaffolds:a review[J].Carbohydrate Polymers,2019,224:115144.
[5] Zhang M,Wang G,Wang D,et al.Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications[J].International Journal of Biological Macromolecules,2021,175:481-494.
[6] Fang Y,Xu Y,Wang Z,et al.3D porous chitin sponge with high absorbency,rapid shape recovery,and excellent antibacterial activities for noncompressible wound[J].Chemical Engineering Journal,2020,388:124169.
[7] Li R,Hu P,Ren X,et al.Antimicrobial N-halamine modified chitosan films[J].Carbohydrate Polymers,2013,92(1):534-539.
[8] Lin M H,Wang Y H,Kuo C H,et al.Hybrid ZnO/chitosan antimicrobial coatings with enhanced mechanical and bioactive properties for titanium implants[J].Carbohydrate Polymers,2021,257:117639.
[9] Yin M,Lin X,Ren T,et al.Cytocompatible quaternized carboxymethyl chitosan/poly(vinyl alcohol) blend film loaded copper for antibacterial application[J].International Journal of Biological Macromolecules,2018,120:992-998.
[10] Yin M,Wan S,Ren X,et al.Development of inherently antibacterial,biodegradable,and biologically active chitosan/pseudo-protein hybrid hydrogels as biofunctional wound dressings[J].ACS Applied Materials & Interfaces,2021,13(12):14688-14699.
[11] Yin M,Wang Y,Zhang Y,et al.Novel quaternarized N-halamine chitosan and polyvinyl alcohol nanofibrous membranes as hemostatic materials with excellent antibacterial properties[J].Carbohydrate Polymers,2020,232:115823.
[12] Zheng Y,Pan N,Liu Y,et al.Novel porous chitosan/N-halamine structure with efficient antibacterial and hemostatic properties[J].Carbohydrate Polymers,2021,253:117205.
[13] Peng X,Xu X,Deng Y,et al.Ultrafast self-gelling and wet adhesive powder for acute hemostasis and wound healing[J].Advanced Functional Materials,2021,DOI:10.1002/adfm.202102583.
[14] Zhang Y,Yin M,Li L,et al.Construction of aerogels based on nanocrystalline cellulose and chitosan for high efficient oil/water separation and water disinfection[J].Carbohydrate Polymers,2020,243:116461.
[15] Ma W,Li L,Lin X,et al.Novel ZnO/N-halamine-mediated multifunctional dressings as quick antibacterial agent for biomedical applications[J].ACS Applied Materials & Interfaces,2019,11(34):31411-31420.
[16] Ma W,Li J,Liu Y,et al.Preparation and characterization of excellent antibacterial TiO2/N-halamines nanoparticles[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2016,506:284-290.
[17] Li L,Ma W,Cheng X,et al.Synthesis and characterization of biocompatible antimicrobial N-halamine-functionalized titanium dioxide core-shell nanoparticles[J].Colloids and Surfaces B:Biointerfaces,2016,148:511-517.
[18] Pan N,Liu Y,Ren X,et al.Fabrication of cotton fabrics through in-situ reduction of polymeric N-halamine modified graphene oxide with enhanced ultraviolet-blocking,self-cleaning,and highly efficient,and monitorable antibacterial properties[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2018,555:765-771.
[19] Kong Q,Li Z,Ding F,et al.Hydrophobic N-halamine based POSS block copolymer porous films with antibacterial and resistance of bacterial adsorption performances[J].Chemical Engineering Journal,2021,410:128407.
[20] Razzak M T,Darwis D,Zainuddin,et al.Irradiation of polyvinyl alcohol and polyvinyl pyrrolidone blended hydrogel for wound dressing[J].Radiation Physics and Chemistry,2001,62(1):107-113.