烟碱分子印迹聚合物是烟碱与功能单体通过共价或非共价作用缔合而成的一种高分子材料,因其表面及内部具有与烟碱分子的形状和大小高度吻合的印迹空腔,对烟碱具有特异性识别作用,因而被广泛地应用于涉及烟碱的传感器、固相萃取材料、色谱固定相和透皮给药系统等领域。对烟碱分子印迹聚合物制备技术进行了综述,主要包括本体聚合法、原位聚合法、表面修饰印迹技术、悬浮聚合法和沉淀聚合法等,并对各种聚合法的原理、研究现状、优缺点及适用范围进行归纳分析。最后,介绍了烟碱分子印迹聚合物在相关领域的应用情况,以期为烟碱分子印迹聚合物的进一步研发提供参考。
Nicotine molecularly imprinted polymers (NMIPs) is a kind of polymer materials formed by the covalent or non-covalent association of nicotine and functional monomer.Because the imprinted cavities on the surface and inside have same shapes and sizes as nicotine molecules,and has a specific recognition effect on nicotine,it has been widely used in the fields of sensors,solid phase extraction materials,chromatographic stationary phase,transdermal drug delivery system,etc.In this article,the preparation technologies of NMIPs were reviewed,including bulk polymerization,in-situ polymerization,surface modified imprinting technology,suspension and precipitation polymerization.In addition,the principle,research status,advantages and disadvantages as well as application scope of various technologies were summarized,which could be expected to provide valuable references for the further research and development of NMIPs.
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基金资助
中国烟草总公司云南省公司科技计划重点项目(2018530000241026)
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