尽管医学水平飞速进步,但伤口细菌感染仍严重威胁着人类健康。抗菌水凝胶具有广谱抗菌活性、优异的生物相容性和亲水性,并且抗菌水凝胶的结构与天然细胞外基质相似,已被作为一种有效减轻伤口细菌感染的治疗手段广泛应用于伤口愈合。根据水凝胶的抗菌机理,综述了自身具有抗菌活性的水凝胶、装载抗菌剂的水凝胶及刺激响应型抗菌水凝胶在伤口敷料中的应用研究进展。
Despite the rapid advancement of human medicine,wound bacterial infection is still one of the serious threats to human health.The antibacterial hydrogel has broad-spectrum antibacterial activity,excellent biocompatibility and hydrophilicity.The structure of the hydrogel is similar to that of natural extracellular matrix.It has been widely used in the field of wound healing as effective treatment for alleviating wound bacterial infections.According to the different antibacterial mechanisms of hydrogels,reviewed the research progress of inherent antimicrobial hydrogels,hydrogels loaded with antibacterial agents,and stimuli-response type antibacterial hydrogels.The application prospects of the hydrogels in the biomedical field of wound dressings were look forwarded.
[1] Tan S Y,Tatsumura Y.Alexander Fleming (1881—1955):discoverer of penicillin[J].Singapore Medical Journal,2015,56(7):366.
[2] Blair J,Webber M A,Baylay A J,et al.Molecular mechanisms of antibiotic resistance[J].Nature Reviews Microbiology,2015,13(1):42-51.
[3] Boyer C,Corrigan N A,Jung K,et al.Copper-mediated living radical polymerization (atom transfer radical polymerization and copper(0) mediated polymerization):from fundamentals to bioapplications[J].Chemical Reviews,2015,116(4):1803-1949.
[4] Rita B A,Anja T,Jacob B,et al.Species-specific activity of antibacterial drug combinations[J].Nature,2018,559:259-263.
[5] Zhong Y,Xiao H,Seidi F,et al.Natural polymer-based antimicrobial hydrogels without synthetic antibiotics as wound dressings[J].Biomacromolecules,2020,21(8):2983-3006.
[6] Ahmadi F,Oveisi Z,Samani M,et al.Chitosan based hydrogels:characteristics and pharmaceutical applications[J].Research in Pharmaceutical Sciences,2015,10(1):1-16.
[7] Hamid H,Sara M,Hudson S M,et al.Chitosan based hydrogels and their applications for drug delivery in wound dressings:a review[J].Carbohydrate Polymers,2018,199:445-460.
[8] Chen H L,Cheng J W,Ran L X,et al.An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing[J].Carbohydrate Polymers,2018,201:522-531.
[9] Xue Y,Xiao H,Zhang Y.Antimicrobial polymeric materials with quaternary ammonium and phosphonium salts[J].International Journal of Molecular Sciences,2015,16(2):3626-3655.
[10] Zhao X,Guo B,Hao W,et al.Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing[J].Nature Communications,2018,9:2784.
[11] Li S,Dong S,Xu W,et al.Antibacterial hydrogels[J].Advanced Science,2018,5(5):170052.
[12] Kiristi M,Singh V V,Efdá Berta,et al.Lysozyme-based antibacterial nanomotors[J].ACS Nano,2015,9(9):9252.
[13] Dai C,Zhou Z,Guan Z,et al.A multifunctional metallohydrogel with injectability,self-healing,and multistimulus-responsiveness for bioadhesives[J].Macromolecular Materials and Engineering,2018,303(10):1800305.
[14] Li Z,Chen S,Wu B,et al.Multifunctional dual ionic-covalent membranes for wound healing[J].ACS Biomaterials Science & Engineering,2020,6:6949-6960.
[15] Gan D,Xing W,Jiang L,et al.Plant-inspired adhesive and tough hydrogel based on Ag-Lignin nanoparticles-triggered dynamic redox catechol chemistry[J].Nature Communications,2019,10(1):1487.
[16] Tian R,Qiu X,Yuan P,et al.Fabrication of self-healing hydrogels with on-demand antimicrobial activity and sustained biomolecule release for infected skin regeneration[J].ACS Applied Materials & Interfaces,2018,10(20):17018-17027.
[17] James,Stuart L.Metal-organic frameworks[J].Chemical Society Reviews,2003,32(5):276-288.
[18] Furukawa H,Cordova K E,M O'Keeffe,et al.The chemistry and applications of metal-organic frameworks[J].Science,2013,341(6149):974.
[19] Furukawa H,Ko N,Go Y B,et al.Ultrahigh porosity in metal-organic frameworks[J].Science,2010,329(5990):424-428.
[20] Hailili R,Wang L,Qy J Z,et al.Planar Mn4O cluster homochiral metal-organic framework for HPLC separation of pharmaceutically important (+/-)-ibuprofen racemate[J].Inorganic Chemistry,2015,54(8):3713-3715.
[21] Lin S,Liu X,Tan L,et al.Porous iron-carboxylate metal-organic framework:a novel bioplatform with sustained antibacterial efficacy and nontoxicity[J].ACS Appl Mater Interfaces,2017,9(22):19248-19257.
[22] Huang G,Li Y,Qin Z,et al.Hybridization of carboxymethyl chitosan with MOFs to construct recyclable,long-acting and intelligent antibacterial agent carrier[J].Carbohydrate Polymers,2020,233:115848.
[23] Zhang Y,Sun P P,Zhang L,et al.Silver-infused porphyrinic metal-organic framework:surface-adaptive,on-demand nanoplatform for synergistic bacteria killing and wound disinfection[J].Advanced Functional Materials,2019,29(11):1808594.
[24] Paz F A,Klinowski J,Vilela S,et al.Ligand design for functional metal-organic frameworks[J].Chemical Society Reviews,2012,41(3):1088-1110.
[25] Sara,Abednatanzi,Parviz,et al.Mixed-metal metal-organic frameworks[J].Chemical Society reviews,2019,48(9):2535-2565.
[26] Huxford R C,Rocca J D,Lin W.Metal-organic frameworks as potential drug carriers[J].Current Opinion in Chemical Biology,2010,14(2):262-268.
[27] Liang S,Wu X L,Xiong J,et al.Metal-organic frameworks as novel matrices for efficient enzyme immobilization:an update review[J].Coordination Chemistry Reviews,2019,406:213149.
[28] Yang Q H,Xu Q,Jiang H L,et al.Metal-organic frameworks meet metal nanoparticles:synergistic effect for enhanced catalysis[J].Chemical Society Reviews,2017,46(15):4774-4808.
[29] Zacher D,Shekhah O,Woell C,et al.Thin films of metal-organic frameworks[J].Chemical Society Reviews,2009,38(5):1418.
[30] Wang K,Yin Y,Li C,et al.Facile synthesis of zinc(Ⅱ)-carboxylate coordination polymer particles and their luminescent,biocompatible and antibacterial properties[J].Crystengcomm,2011,13(20):6231-6236.
[31] Han D,Li Y,Liu X,et al.Rapid bacteria trapping and killing of metal-organic frameworks strengthened photo-responsive hydrogel for rapid tissue repair of bacterial infected wounds[J].Chemical Engineering Journal,2020,396:125194.
[32] Yao X,Zhu G,Zhu P,et al.Omniphobic ZIF-8@hydrogel membrane by microfluidic-emulsion-templating method for wound healing[J].Advanced Functional Materials,2020,30(13):1909389.
[33] Mookherjee N,Anderson M A,Haagsman H P,et al.Antimicrobial host defence peptides:functions and clinical potential[J].Nature Reviews Drug Discovery,2020,19(5):311-332.
[34] Brogden K A.Antimicrobial peptides:pore formers or metabolic inhibitors in bacteria？[J].Nature Reviews Microbiology,2005,3(3):238-250.
[35] Thapa R K,Diep D B,Tnnesen H H.Topical antimicrobial peptide formulations for wound healing:current developments and future prospects[J].Acta Biomaterialia,2020,103:52-67.
[36] Schnaider L,Brahmachari S,Schmidt N W,et al.Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity[J].Nature Communications,2017,8(1):1-10.
[37] Wan Y,Liu L,Yuan S,et al.pH-responsive peptide supramolecular hydrogels with antibacterial activity[J].Langmuir,2017,33(13):3234.
[38] Hou S,Liu Y,Feng F,et al.Polysaccharide-peptide cryogels for multidrug-resistant-bacteria infected wound healing and hemostasis[J].Advanced Healthcare Materials,2020,9(3):1901041.
[39] Heleno S A,Martins A,Queiroz M J R P,et al.Bioactivity of phenolic acids:metabolites versus parent compounds:a review[J].Food Chemistry,2015,173:501-513.
[40] Fan T,Yeh J,Leung K,et al.Angiogenesis:from plants to blood vessels[J].Trends in Pharmacological Sciences,2006,27(6):297-309.
[41] Carson C F,Hammer K A,Riley T V.Melaleuca alternifolia (tea tree) oil:a review of antimicrobial and other medicinal properties[J].Clin Microbiol Rev,2006,2006,19(1):50.
[42] Gulcin I,Huyut Z,Elmastas M,et al.Radical scavenging and antioxidant activity of tannic acid[J].Arabian Journal of Chemistry,2010,3(1):43-53.
[43] Hong K H.Polyvinyl alcohol/tannic acid hydrogel prepared by a freeze-thawing process for wound dressing applications[J].Polymer Bulletin,2016,74(7):1-12.
[44] Jing J,Liang S F,Yan Y F,et al.Fabrication of hybrid hydrogels from silk fibroin and tannic acid with enhanced gelation and antibacterial activities[J].ACS Biomaterials Science and Engineering,2019,5(9):4601-4611.
[45] Yang W,Fortunati E,Bertoglio F,et al.Polyvinyl alcohol/chitosan hydrogels with enhanced antioxidant and antibacterial properties induced by lignin nanoparticles[J].Carbohydrate Polymers,2018,181:275-284.
[46] Xing R,Liu Y,Zou Q,et al.Self-assembled injectable biomolecular hydrogels towards phototherapy[J].Nanoscale,2019,11(46):22182-22195.
[47] Liu Y,Li F,Guo Z,et al.Silver nanoparticle-embedded hydrogel as a photothermal platform for combating bacterial infections[J].Chemical Engineering Journal,2019,382:122990.
[48] Chen S,Tang F,Tang L,et al.Synthesis of Cu-nanoparticle hydrogel with self-healing and photothermal properties[J].ACS Applied Materials & Interfaces,2017,9(24):20895-20903.
[49] Mao C,Xiang Y,Liu X,et al.Photo-inspired antibacterial activity and wound healing acceleration by hydrogel embedded with Ag/Ag@AgCl/ZnO nanostructures[J].ACS Nano,2017,11(9):9010-9021.
[50] Wang J,Zhang C,Yang Y,et al.Poly (vinyl alcohol)(PVA) hydrogel incorporated with Ag/TiO2 for rapid sterilization by photoinspired radical oxygen species and promotion of wound healing[J].Applied Surface Science,2019,494(15):708-720.
[51] Li Y,Liu X,Tan L,et al.Rapid sterilization and accelerated wound healing using Zn2+ and graphene oxide modified g-C3N4 under dual light irradiation[J].Advanced Functional Materials,2018,28(30):1800299.
[52] Liang Y P,Zhao Xin,Hu T L,et al.Adhesive hemostatic conducting injectable composite hydrogels with sustained drug release and photothermal antibacterial activity to promote full-thickness skin regeneration during wound healing[J].Small,2019,15(12):1900046.
[53] Zhang X,Zhang C,Yang Y,et al.Light-assisted rapid sterilization by a hydrogel incorporated with Ag3PO4/MoS2 compo-sites for efficient wound disinfection[J].Chemical Engineering Journal,2019,374:596-604.
[54] Sang Y,Li W,Liu H,et al.Construction of nanozyme-hydrogel for enhanced capture and elimination of bacteria[J].Advanced Functional Materials,2019,29(22):1900518.
[55] Huang X,Wei J J,Zhang M Y,et al.Water-based black phosphorus hybrid nanosheets as a moldable platform for wound healing applications[J].ACS Applied Materials & Interfaces,2018,10(41):35495-35502.
[56] Mao C,Xiang Y,Liu X,et al.Repeatable photodynamic therapy with triggered signaling pathways of fibroblast cell proliferation and differentiation to promote bacteria-accompanied wound healing[J].ACS Nano,2018,12:1747-1759.
[57] Fan X,Yang F,Huang J,et al.Metal-organic-framework-derived 2D carbon nanosheets for localized multiple bacterial eradication and augmented anti-infective therapy[J].Nano Letters,2019,19(9):5885-5896.
[58] Liang Y,Wang M,Zhang Z,et al.Facile synthesis of ZnO QDs@GO-CS hydrogel for synergetic antibacterial applications and enhanced wound healing[J].Chemical Engineering Journal,2019,378:122043.
[59] Namivandi-Zangeneh R,Wong E H H,Boyer C,et al.Synthe-tic antimicrobial polymers in combination therapy:tackling antibiotic resistance[J].ACS Infectious Diseases,2021,7:215-253.
[60] Huo D,Gao J,Guo B,et al.Silver nanoshells as tri-mode bactericidal agents integrating long term antibacterial,photohyperthermia and triggered Ag+ release capabilities[J].RSC Advances,2013,3(27):10632-10638.
[61] Huang S,Liu H,Liao K,et al.Functionalised GO nanovehicle with nitric oxide release and photothermal activity-based hydrogels for bacteria-infected wound healing[J].ACS Applied Materials & Interfaces,2020,12:28952-28964.
[62] Yu Y T,Shi S W,Wang Y,et al.A ruthenium nitrosyl-functionalized magnetic nanoplatform with near-infrared light-controlled nitric oxide delivery and photothermal effect for enhanced antitumor and antibacterial therapy[J].ACS Applied Materials and Interfaces,2020,12(1):312-321.
基金资助
国家自然科学基金(52063006);贵州省科技计划项目([2019]2166);贵州省交通运输厅科技项目(2019-112-016)
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