The purpose was to obtain slow release fibers with the advantages of less toxicity,less pollution,high efficacy and less residue.Firstly,cellulose acetate as drug delivery carrier,avermectin as released pesticide,the drug-loaded fibers with core-shell structure were made through coaxial electrospinning technology,and characterized their structure and morphology.The results showed that the fibers had obvious core-shell structure,although the addition of avermectin damaged the crystallinity of cellulose acetate.Moreover,physical action between cellulose acetate and avermectin did not affect the efficiency of pesticide.Finally,The release behavior of avermectin with different concentrations from core-shell fibers was further investigated.There were three distinct releasing stages in the whole process,namely,delayed-release,uniformly slow-release and rather slow-release,which were beneficial for effectively releasing avermectin.
Zhao Dongmei, Liu Yu, Chu Xiaoyu, Jie Weiguang
. Preparation and study of drug loaded fiber with nuclear-shell structure[J]. New Chemical Materials, 2020
, 48(12)
: 129
-132
.
DOI: 10.19817/j.cnki.issn 1006-3536.2020.12.031
[1] Anton F.Process and apparatus for preparing artificial threads,US 1975504 A[P].1934.
[2] Chen M,Gao S,Wang P,et al.The application of electrospinning used in meniscus tissue engineering[J].Journal of Biomaterials Science Polymer Edition,2018,29(4):461-475.
[3] Agarwal S,Greiner A,Wendorff J H.Functional materials by electrospinning of polymers[J].Progress in Polymer Science,2013,38(6):963-991.
[4] Persano L.Industrial upscaling of electrospinning and applications of polymer nanofibers:a review[J].Macromolecular Materials & Engineering,2013,298(5):504-520.
[5] Sun B,Long Y Z,Zhang H D,et al.Advances in three-dimensional nanofibrous macrostructures via electrospinning[J].Progress in Polymer Science,2014,39(5):862-890.
[6] Liu Q,Zhu J,Zhang L,et al.Recent advances in energy materials by electrospinning[J].Renewable & Sustainable Energy Reviews,2018,81:1825-1858.
[7] Mcclellan P,Landis W J.Recent applications of coaxial and emulsion electrospinning methods in the field of tissue engineering[J].Bioresearch Open Access,2016,5(1):212-227.
[8] Tao C,Zhang Y,Li B,et al.Hierarchical micro/submicrometer-scale structured scaffolds prepared via coaxial electrospinning for bone regeneration[J].Journal of Materials Chemistry B,2017,5(46):9219-9228.
[9] Lin X,Tang D,Lyu H,et al.Poly(N-isopropylacrylamide)/polyurethane core-sheath nanofibres by coaxial electrospinning for drug controlled release[J].Iet Micro & Nano Letters,2016,11(5):260-263.
[10] Han D,Yu X,Chai Q,et al.Stimuli-responsive self-immolative polymer nanofiber membranes formed by coaxial electrospinning[J].ACS Applied Materials & Interfaces,2017,9(13):11858-11865.
[11] Choi S J,Chattopadhyay S,Kim J J,et al.Coaxial electrospinning of WO3 nanotubes functionalized with bio-inspired Pd catalysts and their superior hydrogen sensing performance[J].Nanoscale,2015,8(17):9159-9166.
[12] Senthilkumar N,Kumar G G,Manthiram A.3D hierarchical core-shell nanostructured arrays on carbon fibers as catalysts for direct urea fuel cells[J].Advanced Energy Materials,2017,8(6):1-11.
[13] Li S,Shen X,Liu J,et al.Synthesis of Ta3N5/Bi2MoO6 core-shell fiber-shaped heterojunctions as efficient and easily recyclable photocatalysts[J].Environmental Science:Nano,2017,4:1155-1167.
[14] Ekladious I,Liu R,Varongchayakul N.Reinforcement of polymeric nanoassemblies for ultra-high drug loadings,modulation of stiffness and release kinetics,and sustained therapeutic efficacy[J].Nanoscale,2018,10(18):8360-8366.
[15] Khaled S A,Alexander M R,Wildman R D,et al.3D extrusion printing of high drug loading immediate release paracetamol tablets[J].International Journal of Pharmaceutics,2018,538(1-2):223-230.
[16] Mohammadian F,Eatemadi A.Drug loading and delivery using nanofibers scaffolds[J].Artif Cells Nanomed Biotechnol,2017,45(5):881-888.
[17] Zhang K,Li Z,Kang W,et al.Preparation and characterization of tree-like cellulose nanofiber membranes via the electrospinning method[J].Carbohydrate Polymers,2017,183:62-69.
[18] Ohkawa K.Nanofibers of cellulose and its derivatives fabricated using direct electrospinning[J].Molecules,2015,20(5):9139-9154.
[19] Lee H,Nishino M,Sohn D,et al.Control of the morphology of cellulose acetate nanofibers via electrospinning[J].Cellulose,2018,25(5):2829-2837.
[20] Nair S S,Mathew A P.Porous composite membranes based on cellulose acetate and cellulose nanocrystals via electrospinning and electrospraying[J].Carbohydrate Polymers,2017,175:149-157.
[21] Otsuka I,Njinang C N,Borsali R.Simple fabrication of cellulose nanofibers via electrospinning of dissolving pulp and tunicate[J].Cellulose,2017,24(8):1-8.
[22] Li Z Z,Chen J F,Liu F,et al.Study of UV-shielding properties of novel porous hollow silica nanoparticle carriers for avermectin[J].Pest Management Science,2007,63(3):241-246.
[23] Wen L X,Li Z Z,Zou H K,et al.Controlled release of avermectin from porous hollow silica nanoparticles[J].Pest Management Science,2005,61(6):583-590.
[24] Li Z Z,Xu S A,Wen L X,et al.Controlled release of avermectin from porous hollow silica nanoparticles:influence of shell thickness on loading efficiency,UV-shielding property and release[J].Journal of Controlled Release,2006,111(1):81-88.
