Preparation of nano-HA modified by PBLA

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  • 1.Department of Biochemistry,Nanchang University College of Science and Technology, Nanchang 330029;
    2.Nanchang University,Nanchang 330031

Online published: 2020-10-20

Abstract

A preparation method of hydroxyapatite(HA)surface modification was described,PBLA-g-HA was prepared by ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride.First,HA was reacted with silane coupling agent KH550 to obtain modified hydroxyapatite (HAAPS) with active amino groups on its surface.Secondly,HAAPS initiated the ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride (BLA-NCA) to obtain hydroxyapatite(PBLA-g-HA) grafted with polyaspartic acid benzyl ester (PBLA).The surface of HA was changed from hydrophilic to hydrophobic.The results were characterized by FT-IR,TGA.FT-IR and TGA showed that HA was successfully grafted.By controlling the reaction time and ratio,the grafting amount of PBLA on the surface of HA was 28.32%~60.48%.The dispersity experiment confirmed that HA modified by PBLA could significantly increase the hydrophobicity of HA surface,and prevented the aggregation of HA nanoparticles.

Cite this article

Xu Min, Xiong Bing, Shu Yang, Guo Jianye, Shuai Wenyuan, Huang Ping . Preparation of nano-HA modified by PBLA[J]. New Chemical Materials, 2020 , 48(10) : 282 -285 . DOI: 10.19817/j.cnki.issn 1006-3536.2020.10.060

References

[1] Ren Pengfei, Wang Faming, Zhan Tiantian, et al.A biomimetic nano-hydroxyapatite/chitosan/poly(methyl vinylether-alt-maleic anhydride) composite with excellent biocompatibility[J].Materials Letters, 2020, 261:127102.
[2] 张明玉, 蔡文迪, 孙岚, 等.微波烧结法制备羟基磷灰石/TiO2复合涂层[J].化工新型材料, 2018, 46(8):172-175.
[3] Elangomannan S, Louis K, Dharmaraj B M, et al.Carbon nanofiber/polycaprolactone/mineralized hydroxyapatite nanofibrous scaffolds for potential orthopedic applications[J].ACS Applied Materials& Interfaces, 2017, 9:6342-6355.
[4] Ying Ruilian, Wang Huachun, Sun Ruixue, et al.Preparation and properties of a highly dispersed nano-hydroxyapatite colloid used as a reinforcing filler for chitosan[J].Materials Science & Engineering C, 2020, 110:110689.
[5] Pietrzykowska E, Mukhovskyi R, Chodara A, et al.Composites of polylactide and nano-hydroxyapatite created by criomilling and warm isostatic pressing for bone implants applications[J].Materials Letters, 2019, 236:625-628.
[6] Zeng Liang, Wang Haibo, Fu Guoxin, et al.A new approach for synthesis of the comb-shaped poly (ε-caprolactone) brushes on the surface of nano-hydroxyapatite by combination of ATRP and ROP[J].Journal of Colloid and Interface Science, 2010, 352:36-42.
[7] Dai Yanfeng, Xu Min, Wei Junchao, et al.Surface modification of hydroxyapatite nanoparticles by poly (L-phenylalanine) via ROP of L-phenylalanine N-carboxyanhydride (Pha-NCA)[J].Applied Surface Science, 2012, 258:2850-2855.
[8] Li Linlong, Shi Xincui, Wang Zongliang, et al.Porous scaffolds of poly(lactic-co-glycolic acid) and mesoporous hydroxyapatite surface modified by poly(γ-benzyl-L-glutamate) (PBLG) for in vivo bone repair[J].ACS Biomaterials Science & Engineering, 2019, 5:2466-2481.
[9] 马丽芳, 张婷, 李瑶, 等.聚天冬氨酸苄酯修饰的泊洛沙姆纳米粒制备和表征[J].四川大学学报:工程科学版, 2016, 48(3):202-208.
[10] Choi H W, Lee H J, Kim K J, et al.Surface modification of hydroxyapatite nanocrystals by grafting polymers containing phosphonic acid groups[J].Journal of Colloid & Interface Science, 2006, 304(1):277-281.
[11] 廖岚.聚(γ-苄基-L-谷氨酸)改性纳米羟基磷灰石/聚乳酸骨组织工程支架制备及生物性能研究[D].南昌:南昌大学, 2014.
[12] Wei Junchao, Liu Aixue, Chen Lei, et al.The surface modification of hydroxyapatite nanoparticles by the ring opening polymerization of γ-benzyl-L-glutamate N-carboxyanhydride[J].Macromolecular Bioscience, 2009, 9(7):631-638.
[13] Munegumi T, Meng Y Q, Harada K.Polypeptide formation by heating N-t-butyloxycarbonyl acidic aminoacid derivatives[J].Asian Journal of Chemistry, 2014, 26(15):4716-4722.
[14] 刘伟芬, 李禄辉, 乔鹏, 等.两亲性嵌段共聚物聚苯丙氨酸-聚天冬氨酸的合成与表征[J].国际药学研究杂志, 2016, 43(4):718-722.
[15] 马丽芳, 马鹏里, 张婷, 等.甘草次酸修饰的聚天冬氨酸苄酯纳米粒制备及表征[J].四川大学学报:工程科学版, 2015, 47(3):187-192.
[16] Pu Yuji, Zhang Longgui, Zheng Hui, et al.Drug release of pH-sensitive poly(L-aspartate)-b-poly(ethylene glycol) micelles with POSS cores[J].Polymer Chemistry, 2014, 5:463-470.
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