A preparation method of hydroxyapatite(HA)surface modification was described,PBLA-g-HA was prepared by ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride.First,HA was reacted with silane coupling agent KH550 to obtain modified hydroxyapatite (HAAPS) with active amino groups on its surface.Secondly,HAAPS initiated the ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride (BLA-NCA) to obtain hydroxyapatite(PBLA-g-HA) grafted with polyaspartic acid benzyl ester (PBLA).The surface of HA was changed from hydrophilic to hydrophobic.The results were characterized by FT-IR,TGA.FT-IR and TGA showed that HA was successfully grafted.By controlling the reaction time and ratio,the grafting amount of PBLA on the surface of HA was 28.32%～60.48%.The dispersity experiment confirmed that HA modified by PBLA could significantly increase the hydrophobicity of HA surface,and prevented the aggregation of HA nanoparticles.
Xu Min, Xiong Bing, Shu Yang, Guo Jianye, Shuai Wenyuan, Huang Ping
. Preparation of nano-HA modified by PBLA[J]. New Chemical Materials, 2020
, 48(10)
: 282
-285
.
DOI: 10.19817/j.cnki.issn 1006-3536.2020.10.060
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