Cartilage tissue repair has always been a research hotspot in tissue engineering (TE).The medical grade polycaprolactone (m-PCL) was prepared by melt electrospinning direct writing technology.A bone-cartilage composite scaffold with a porosity of 90.4% was prepared,the average fiber diameter was 20.4～36.2μm,the 10-layer fiber tensile strength was 3.44～5.75MPa,and the compressive strength was 0.032MPa.The results shown that the m-PCL scaffold prepared by melt electrospinning direct writing technology had good mechanical strength,high porosity and micron fiber diameter,and can be adjusted by mesh pore size and fiber membrane layer.And the selection of different scaffold materials can be applied to each layered structure of bone-cartilage,and had broad application prospects in TE and its medical field.
Yao Ziqi, Zhang Youchen, Li Haoyi, Jiao Zhiwei, Lei Wenlong
. Preparation and characterization of polymer melt electrospinning PCL bone-cartilage composite scaffold[J]. New Chemical Materials, 2020
, 48(8)
: 271
-275
.
DOI: 10.19817/j.cnki.issn 1006-3536.2020.08.059
[1] Simon T M,Jackson D W.Articular cartilage:injury pathways and treatment options[J].Sports Medicine and Arthroscopy Review,2006,14(3):146-154.
[2] Beris A E,Lykissas M G,Papageorgiou C D,et al.Advances in articular cartilage repair[J].Injury-international Journal of the Care of the Injured,2005,36(4):S14-S23.
[3] Ahmed T A,Hincke M T.Strategies for articular cartilage lesion repair and functional restoration[J].Tissue Engineering Part B Reviews,2010,16(3):305-329.
[4] Hunziker E B.Biologic repair of articular cartilage.defect models in experimental animals and matrix requirements[J].Clinical Orthopaedics & Related Research,1999,367(367 Suppl):135-146.
[5] Zhang L,Hu J,Athanasiou K A.The role of tissue engineering in articular cartilage repair and regeneration[J].Critical Reviews in Biomedical Engineering,2009,37(1-2):1.
[6] Solchaga L A,Yoo J U,Lundberg M,et al.Hyaluronan-based polymers in the treatment of osteochondral defects[J].Journal of Orthopaedic Research:Official Publication of The Orthopaedic Research Society,2000,18(5):773-780.
[7] Wang C C,Yang K C,Lin K H,et al.A highly organized three-dimensional alginate scaffold for cartilage tissue engineering prepared by microfluidic technology[J].Biomaterials,2011,32(29):7118-7126.
[8] 刘清宇,王富友,杨柳.关节软骨组织工程支架的研究进展[J].中国修复重建外科杂志,2012(10):1247-1250.
[9] Xu Y,Guo X,Yang S,et al.Construction of bionic tissue engineering cartilage scaffold based on 3D printing and oriented frozen technology[J].Journal of Biomedical Materials Research Part A,2018,106(6).
[10] Bose S,Darsell J,Kintner M,et al.Pore size and pore volume effects on alumina and TCP ceramic scaffolds[J].Materials Science & Engineering C,Biomimetic and,Supramolecular Systems,2003,23(4):479-486.
[11] Laupattarakasem W,Laopaiboon M,Laupattarakasem P,et al.Arthroscopic debridement for osteoarthritis of the knee | cochrane summaries[M].John Wiley & Sons,Ltd,2008.
[12] Reddi A H,Gay R,Gay S,et al.Transitions in collagen types during matrix-induced cartilage,bone,and bone marrow formation[J].Proceedings of the National Academy of Sciences,1977,74(12):5589-5592.
[13] Watanabe H,Watanabe H,Kimata K.The roles of proteoglycans for cartilage[J].Clinical Calcium,2006,16(6):1029.
[14] Zhang L,Hu J,Athanasiou K A.The role of tissue engineering in articular cartilage repair and regeneration[J].Critical Reviews in Biomedical Engineering,2009,37(1-2):1.
[15] 段小军,王富友,杨柳.骨软骨组织界面结构及骨软骨复合组织构建研究[J].中国矫形外科杂志,2013(17):39-43.
[16] Ristovski N,Bock N,Liao S,et al.Improved fabrication of melt electrospun tissue engineering scaffolds using direct writing and advanced electric field control[J].Biointerphases,2015,10(1):011006.
[17] 刘扬.组织工程化构建骨支架材料—无机活性元素支架材料的机械强度的研究[D].合肥:安徽医科大学,2011.
