Cartilage tissue repair has always been a research hotspot in tissue engineering (TE).The medical grade polycaprolactone (m-PCL) was prepared by melt electrospinning direct writing technology.A bone-cartilage composite scaffold with a porosity of 90.4% was prepared,the average fiber diameter was 20.4~36.2μm,the 10-layer fiber tensile strength was 3.44~5.75MPa,and the compressive strength was 0.032MPa.The results shown that the m-PCL scaffold prepared by melt electrospinning direct writing technology had good mechanical strength,high porosity and micron fiber diameter,and can be adjusted by mesh pore size and fiber membrane layer.And the selection of different scaffold materials can be applied to each layered structure of bone-cartilage,and had broad application prospects in TE and its medical field.
Yao Ziqi, Zhang Youchen, Li Haoyi, Jiao Zhiwei, Lei Wenlong
. Preparation and characterization of polymer melt electrospinning PCL bone-cartilage composite scaffold[J]. New Chemical Materials, 2020
, 48(8)
: 271
-275
.
DOI: 10.19817/j.cnki.issn 1006-3536.2020.08.059
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