The thermo-pH dual-sensitive poly(N-isopropylacrylamide-co-maleic acid) hydrogel was prepared by frontal polymerization with N-isopropylacrylamide as the main monomer and maleic acid as the second monomer.The effects of monomer dosage,initiator type,and solvent type on the polymerization process and product properties were studied.The results showed that the product could be prepared in 20 minutes by frontal polymerization,which saved a lot of time compared with traditional solution polymerization.As the amount of maleic acid increased,the maximum temperature and movement speed of the frontal polymerization decreased.The addition of maleic acid monomer made the copolymer hydrogels with pH sensitivity.With the increase of maleic acid content,the water absorption capacity,phase transition temperature and glass transition temperature of the hydrogel increased,but its thermal stability decreased,which realized the modulation of hydrogel performance.
Feng Qiao, Fei Chenhao, Sun Gaoming, Fan Zhen, Kang Jingjing, Zhao Yaqi
. Synthesis and characteristic of poly(N-isopropylacrylamide-co-maleic acid) dual-sensitive hydrogel by frontal polymerization[J]. New Chemical Materials, 2024
, 52(11)
: 110
-114
.
DOI: 10.19817/j.cnki.issn1006-3536.2024.11.008
[1] 钟大根,刘宗华,左琴华,等.智能水凝胶在药物控释系统的应用及研究进展[J].材料导报,2012,26(11):83-88.
[2] Calvert P.Hydrogels for soft machines[J].Advanced Materials,2009,21(7):743-756.
[3] 陈阳.刺激响应性智能水凝胶的合成与性能研究[D].青岛:青岛科技大学,2021.
[4] Schild H G.Poly(N-isopropylacrylamide):experiment,theory and application[J].Progress in Polymer Science,1992,17(2):163-249.
[5] 石梦妮,林廷睿,彭静,等.水凝胶的辐射合成及其应用研究进展[J].中国科学:化学,2020,50(10):1363-1374.
[6] Su J,Yang Y,Chen Z,et al.Preparation and performance of thermosensitive poly(N-Isopropylacrylamide) hydrogels by frontal photopolymerization[J].Polymer International,2019,68:1673-1680.
[7] Pojman J A.Traveling fronts of methacrylic acid polymerization[J].Journal of the American Chemical Society,1991,113(16):6284-6286.
[8] Li Qing,Shen Haixia,Liu Chang,et al.Advances in frontal polymerization strategy:from fundamentals to applications[J].Progress in Polymer Science,2022,127:101514.
[9] Ghazinezhad M,Bozorgian A,Dastnaei P G.A review of frontal polymerization in the chemical industry[J].Int J New Chem,2022,9:623-646.
[10] Feng Qiao,Yan Qingzhi,Ge Chanchun.Synthesis of macroporous polyacrylamide and poly(N-isopropylacrylamide) monoliths via frontal polymerization and investigation of pore structure variation of monoliths[J].Chinese Journal of Polymer Science,2009,27(5):747-753.
[11] 冯巧,夏志伟,张亚轩,等.前端聚合法制备聚N-异丙基丙烯酰胺/碳纳米管复合水凝胶及其性能[J].高分子材料科学与工程,2016,32(5):134-138.
[12] Feng Qiao,Zhao Y,Li H,et al.Frontal polymerization and characterization of interpenetrating polymer networks composed of poly(N-isopropylacrylamide) and polyvinylpyrrolidone[J].Colloid and Polymer Science,2018,296:165-172.
[13] Alzari V,Monticelli O,Nuvoli D,et al.Stimuli responsive hydrogels prepared by frontal polymerization[J].Biomacromolecules,2009,10(9):2672-2677.
[14] Evans A G,Tyrrall E.Heats of polymerization of acrylic acid and derivatives[J].Journal of Polymer Science,1947,4(2):387-396.
[15] Feil H,Bae Y H,Feijen J,et al.Effect of comonomer hydrophilicity and ionization on the lower critical solution temperature of N-isopropylacrylamide copolymers[J].Macromolecules,1993,26(10):2496-2500.
[16] Zhang J T,Cheng S X,Zhuo R X.Preparation of macroporous poly(N-isopropylacrylamide) hydrogel with improved temperature sensitivity[J].Journal of Polymer Science Part A:Polymer Chemistry,2003,41(15):2390-2392.
[17] Velada J L,Liu Y,Huglin M B.Effect of pH on the swelling behaviour of hydrogels based on N-isopropylacrylamide with acidic comonomers[J].Macromolecular Chemistry and Physics,1998,199(6):1127-1134.
