2-hydroxyimino-malononitrile and its Na salt were synthesized using malononitrile as raw material,and confirmed by NMR,IR and elemental analysis.The results showed that two different intermediate products were generated because the order of addition of acetic acid and sodium nitrite.The yields of furazacycline products were 61.4% and 63.6%,respectively when the two intermediates were used as raw materials.The thermal stability of the 2-mercapto-malononitrile sodium salt produced was better than 2-hydroxyimino-malononitrile,and the reaction process for the synthesis of 2-hydroxyimino-malononitrile sodium salt was more intense than 2-hydroxyimino-malononitrile,since the maximum exothermic rate was 47.37W and the temperature rise of the reaction system reached about 10℃.The adiabatic temperature rise of the two reactions was not much different.This research can provide the basis for the synthesis of 2-hydroxyimino-malononitrile and furazamide and the safe operation of the process.
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