水凝胶是高度交联的水溶胀亲水聚合物网络,具有良好的生物相容性,可作为药物载体和功能支架,在组织工程、再生医学和药物递送等领域具有广阔的应用前景。综述了近年来自愈性水凝胶的制备原理和自愈机制,如主客体相互作用、动态共价与非共价作用、金属-配体相互作用和亲疏水作用以及其作为药物载体、仿生支架在组织工程及再生医学方面对创伤修复、填充复杂组织缺陷并诱导再生的应用,指出了自愈性水凝胶目前存在的问题以及其作为药物递送载体所面临的挑战,对其未来临床应用前景进行了展望。
Hydrogel is a highly cross-linked water-swellable hydrophilic polymer network with good biocompatibility.It can be used as a drug carrier and functional scaffold,and has broad application prospects in the fields of tissue engineering,regenerative medicine and drug delivery.The preparation and self-healing mechanisms of self-healing hydrogels in recent years were mainly reviewed,such as:host-guest interaction,dynamic covalent and non-covalent interactions,metal-ligand interactions and hydrophobic interactions.The results of the application of drug carriers and biomimetic matrices in wound healing,filling complex tissue defects and inducing regeneration in tissue engineering and regenerative medicine were introduced,and expounded the current problems of self-healing hydrogels and their potential as drug delivery vehicles.The challenge was to look forward to its future clinical application prospects.
[1] Kim B S,Park I K,Hoshiba T,et al.Design of artificial extracellular matrices for tissue engineering[J].Progress in Polymer Science,2011,36 (2):238-268.
[2] 梁蕊,王晓燕,席国喜.新型pH敏感羧甲基壳聚糖/聚天冬氨酸水凝胶的制备及性能[J].化工新型材料,2013,41 (11):37-40.
[3] Tan H,Marra K G.Injectable,biodegradable hydrogels for tissue engineering applications[J].Materials,2010,3 (3):1746-1767.
[4] Buwalda S J,Boere K W,Dijkstra P J,et al.Hydrogels in a historical perspective:from simple networks to smart materials[J].Journal of Controlled Release,2014,190 (10):254-273.
[5] Li L,Yan B,Yang J,et al.Novel mussel-inspired injectable self-healing hydrogel with anti-biofouling property[J].Advanced Materials,2015,27 (7):1294-1299.
[6] Mahadevaiah S,Robinson K G,Kharkar P M,et al.Decreasing matrix modulus of PEG hydrogels induces a vascular phenotype in human cord blood stem cells[J].Biomaterials,2015,62:24-34.
[7] Vermonden T,Censi R,Hennink W E.Hydrogels for protein delivery[J].Chemical Reviews,2012,112 (5):2853.
[8] 杨忠连,陈明强,徐继红,等.氯化胆碱/尿素低共熔离子液体改性木质素基水凝胶的制备及缓释性能研究[J].化工新型材料,2017,45 (7):202-204.
[9] Weng G,Thanneeru S,He J.Dynamic coordination of Eu-iminodiacetate to control fluorochromic response of polymer hydrogels to multistimuli[J].Advanced Materials,2018,30 (11):1706526.
[10] Sin M C,Lou P T,Cho C H,et al.An intuitive thermal-induced surface zwitterionization for versatile,well-controlled haemocompatible organic and inorganic materials[J].Colloids & Surfaces Biointerfaces,2015,127:54-64.
[11] Liu J,Qi C,Tao K,et al.A sericin/dextran injectable hydrogel as an optically trackable drug delivery system for malignant melanoma treatment[J].ASC Applied Materials & Interfaces,2016,8 (10):6411.
[12] Jiang Y,Chen J,Deng C,et al.Click hydrogels,microgels and nanogels:emerging platforms for drug delivery and tissue engineering[J].Biomaterials,2014,35 (18):4969-4985.
[13] 张亚玲,杨斌,许亮鑫,等.基于动态化学的自愈性水凝胶及其在生物医用材料中的应用研究展望[J].化学学报,2013,71 (4):485-492.
[14] 王健强,肖艳.基于聚肽和海藻酸钠自交联水凝胶的制备与表征[J].功能高分子学报,2018,31 (1):69-74.
[15] Bakker M H,Kieltyka R E,Albertazzi L,et al.Modular supramolecular ureidopyrimidinone polymer carriers for intracellular delivery[J].RSC Advances,2016,6 (112):110600-110603.
[16] Barrow S J,Kasera S,Rowland M J,et al.Cucurbituril-based molecular recognition[J].Chemical Reviews,2015,115 (22):12320-12406.
[17] Shi L,Carstensen H,Hoelzl K,et al.Dynamic coordination chemistry enables free directional printing of biopolymer hydrogel[J].Chemistry of Materials,2017,29 (14):5816-5823.
[18] Mozhdehi D,Neal J A,Grindy S C,et al.Tuning dynamic mechanical response in metallopolymer networks through simultaneous control of structural and temporal properties of the networks[J].Macromolecules,2016,49 (17):6310-6321.
[19] Garzoni M,Baker M B,Leenders C M A,et al.Effect of H-bonding on order amplification in the growth of a supramolecular polymer in water[J].Journal of the American Chemical Society,2016,138 (42):13985-13995.
[20] 叶志鹏,谢曼青,谢家礼,等.基于遥爪型大分子交联剂的动态化学交联水凝胶的黏弹性质[J].功能高分子学报,2018,31 (3):241-247.
[21] Shan M,Gong C,Li B,et al.A pH,glucose,and dopamine triple-responsive,self-healable adhesive hydrogel formed by phenylborate-catechol complexation[J].Polymer Chemistry,2017,8 (19):2997-3005.
[22] Guo R,Su Q,Zhang J,et al.Facile access to multisensitive and self-healing hydrogels with reversible and dynamic boronicester and disulfide linkages[J].Biomacromolecules,2017,18 (4):1356-1364.
[23] Ketabat F,Karkhaneh A,Mehdinavaz A R,et al.Injectable conductive collagen/alginate/polypyrrole hydrogels as a biocompatible system for biomedical applications[J].Journal of Biomaterials Science Polymer Edition,2017,28 (8):794-805.
[24] Giang P V H,Thavasyappan T,Trang D H T,et al.Poly (amino carbonate urethane)-based biodegradable,temperature and pH-sensitive injectable hydrogels for sustained human growth hormone delivery[J].Scientific Reports,2016,6:29978.
[25] Thambi T,Phan V H G,Lee D S.Stimuli-sensitive injectable hydrogels based on polysaccharides and their biomedical applications[J].Macromolecular Rapid Communications,2016,37 (23):1881.
[26] Merino S,Martín C,Kostarelos K,et al.Nanocomposite hydrogels:3D polymer-nanoparticle synergies for on-demand drug delivery[J].ACS Nano,2015,9 (5):4686-4697.
[27] Thakur A,Jaiswal M K,Peak C W,et al.Injectable shear-thinning nanoengineered hydrogels for stem cell delivery[J].Nanoscale,2016,8 (24):12362.
[28] 何贵东,李政,华嘉川,等.水凝胶在医学领域应用研究进展[J].化工新型材料,2017,45 (5):223-225.
[29] Hölzl K,Lin S,Tytgat L,et al.Bioink properties before,during and after 3D bioprinting[J].Biofabrication,2016,8 (3):032002.
[30] Tran N Q,Joung Y K,Lih E,et al.In situ forming and rutin-releasing chitosan hydrogels as injectable dressings for dermal wound healing[J].Biomacromolecules,2011,12 (8):2872.
[31] Rodell C B,Wade R J,Purcell B P,et al.Selective proteolytic degradation of guest-host assembled,injectable hyaluronic acid hydrogels[J].ACS Biomater Sci Eng,2015,1 (4):277-286.
[32] Yesilyurt V,Webber M J,Appel E A,et al.Injectable self-healing glucose-responsive hydrogels with pH-regulated mechanical properties[J].Advanced Materials,2016,28 (1):86-91.
[33] Zhao X,Wu H,Guo B,et al.Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing[J].Biomaterials,2017,122:34-47.
[34] Xu Z,Shi L,Yang M,et al.Fabrication of a novel blended membrane with chitosan and silk microfibers for wound healing:characterization,in vitro and in vivo studies[J].Journal of Materials Chemistry B,2015,3 (17):3634-3642.
[35] Radhakumary C,Antonty M,Sreenivasan K.Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing[J].Carbohydrate Polymers,2011,83 (2):705-713.
[36] Shi L,Zhao Y,Xie Q,et al.Moldable hyaluronan hydrogel enabled by dynamic metal-bisphosphonate coordination chemistry for wound healing[J].Advanced Healthcare Materials,2017,7 (5):1700973.
[37] Hong L T A,Kim Y M,Park H H,et al.An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling[J].Nature Communications,2017,8 (1):533.
[38] Shi L,Han Y,Hilborn J,et al."Smart" drug loaded nanoparticle delivery from a self-healing hydrogel enabled by dynamic magnesium-biopolymer chemistry[J].Chemical Communications,2016,52 (74):11151-11154.
[39] Gao W,Liang Y,Peng X,et al.In situ injection of phenylboronic acid based low molecular weight gels for efficient chemotherapy[J].Biomaterials,2016,105:1-11.
基金资助
国家自然科学基金项目(21562014);贵州中烟科技项目(黔烟工技[2015]8号)
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