在杂化基材的前驱体(PA)中分别引入低分子量的聚乙二醇(PEG)和多壁碳纳米管(MWCNT),通过溶胶-凝胶共混法制备了2组复合组织工程支架基材,有机改性体系PEG/PA和添加了MWCNT的无机改性体系C/PA。并对改性体系的微观结构、热稳定性、溶胀性能以及引入组分与基材的相容性进行了研究,比较了改性体系对脐静脉内皮细胞(HUVEC)形态和粘附行为的影响。制得的C/PA,在去离子水中的溶胀率为15.1%;在pH=7.4的PBS溶液中的溶胀率为16.8%,热稳定性较好,表面硬度适于细胞增殖分布,具有较好的应用前景。
Low molecular weight polyethylene glycol (PEG) and multi-walled carbon nanotubes (MWCNT) were introduced into the precursor of hybrid substrate (PA),and two sets of composite tissue engineering scaffolds,including the organic modified system PEG/PA and inorganic modified system C/PA added with MWCNT were prepared by sol-gel blending method.The microstructures,thermal stability,swelling properties,and the compatibility between the introduced components and matrix of modified system were studied.The effects of modified system on the morphology and adhesion behavior of umbilical vein endothelial cells (HUVEC) were compared.C/PA prepared had the swelling rate of 15.1% in deionized water and 16.8% in PBS solution with pH=7.4.It had good thermal stability,and its surface hardness was suitable for cell proliferation and distribution,so it had a good application prospect.
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基金资助
国家自然科学基金(51202221)
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