采用还原氨化法将不同碳链长度的醛接枝到壳聚糖(CS)主链上,得到取代度(DS)分别为8.82%(CS6a)、19.22%(CS6b)和28.31%(CS6c)的己醛接枝物和DS分别为9.53%(CS12a)、17.8%(CS12b)、33.57%(CS12c)的十二醛接枝物。采用湿法纺丝技术制备了系列N-烷基壳聚糖纤维,并对N-烷基壳聚糖及其纤维材料进行了表征和细胞毒性测试。通过体外全血凝固时间测试评价了材料的凝血性能。研究表明,DS为19.22%,制备的N-烷基壳聚糖纤维的断裂强度和断裂伸长率分别为0.47cN/dtex和12.44%,并且无毒性,体外凝血时间较短为33s,具有较好的凝血性能。
Chitosan (CS) was modified by grafting aldehyde with different carbon chain length into its backbone,and N-hexane chitosan and N-dodecane chitosan were obtained with degree of substitution (DS) of 8.82% (CS6a),19.22% (CS6b),28.31% (CS6c) and 9.53% (CS12a),17.8% (CS12b),33.57% (CS12c) respectively.A series of N-alkyl chitosan fibers were prepared by wet spinning technology,the characterization and cytotoxicity of materials were studied.The coagulation properties of materials were evaluated by measuring the coagulation time of whole blood in vitro.The results showed that the material with DS value of 19.22% (CS6b) had much better blood coagulation property.The study showed that the fracture strength and fracture elongation of fiber were 0.47 cN/dtex and 12.44%,respectively,which was not toxic.The coagulation time was 33s in vitro,which had better coagulation performance.
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基金资助
国家自然科学基金资助项目(315370956)
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