静电纺纳米纤维以其具有模拟细胞外基质(ECM)的结构与功能,已在组织工程支架材料领域受到广泛研究。传统随机排列纳米纤维支架显示出较低的机械强力,缺少足够的生物地形指引,而定向纳米纤维的应用优势凸显。为了扩展定向纳米纤维在组织工程支架的应用,系统综述了近年来不同制备方法在构建血管、肌肉、骨和神经组织工程支架的应用进展。结果表明,三维(3D)定向纳米纤维支架具有明显的使用优势,可以结合多种电纺技术和后加工处理,以及结合其他制备组织工程支架的方法进行制备。
Electrospun nanofiber has been widely used in the area of tissue engineering scaffold material due to its structure and function of emulating extracellular matrix (ECM).Traditional random nanofiber shows lower strength and lacks enough topographic cues,while aligned nanofiber can overcome the shortcomings.In order to extend the application of aligned nanofiber in the area of tissue engineering scaffold,application progress of different preparation methods in construction of blood vessel,muscle,bone and nerves tissue engineering scaffold were studied.Results showed that three dimensional (3D) aligned nanofiber scaffold had obvious advantage in using.It can be prepared through combination of many electrospinning technologies,finishing processes,and some other methods to prepare tissue engineering scaffold.
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基金资助
国家自然科学基金项目(51503168);陕西省创新人才推进计划-青年科技新星项目(2017KJXX-23);陕西省教育厅重点实验室科研计划项目(13JS035);山东省博士后创新项目专项资金资助项目(201504);西安工程大学研究生创新基金(CX201729)
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