微生物污染是导致食品腐败、医疗器械相关感染及疾病传播的关键因素,开发高效抗菌功能材料对保障健康与提高生活质量具有重要意义。静电纺丝技术因其可制备高比表面积、高孔隙率纳米纤维膜的独特优势,成为构建高性能纺织基抗菌材料的理想平台。系统总结了静电纺丝抗菌薄膜的研究进展:首先阐述了包括合成聚合物和天然聚合物的载体材料体系,以及无机、有机小分子和天然源抗菌活性组分的作用机制与复合策略;进而分析了静电纺丝工艺对纤维结构与性能的调控作用,及其在医用纺织品、食品活性包装和过滤材料等领域的应用潜力;最后指出当前技术面临规模化生产、环境安全性与性能平衡等挑战,未来应聚焦智能响应系统、绿色制造及跨学科合作,以推动其产业化应用与可持续发展。
Microbial contamination is a key factor leading to food spoilage,medical device-related infections,and disease transmission.The development of highly efficient antimicrobial functional materials is of great significance for safeguarding human health and improving quality of life.Electrospinning technology,renowned for its unique ability to produce nanofiber membranes with high specific surface area and porosity,serves as an ideal platform for constructing high-performance textile-based antibacterial materials.This review systematically summarized recent research progress in electrospun antibacterial membranes.It began by elaborating on the material systems,including synthetic polymer carriers and natural polymer carriers,as well as antibacterial active components such as inorganic agents,organic small molecules,and natural agents,along with their mechanisms of action and composite strategies.It further analyzed how electrospinning processes regulated fiber structure and properties.The application potential in various fields such as medical textiles,active food packaging,and filtration materials was also discussed.Finally,the review pointed out current challenges in scalability,environmental safety,and performance balance,suggesting that future work should focus on intelligent responsive systems,green manufacturing,and interdisciplinary collaboration to promote industrial application and sustainable development.
[1] Karanth S,Feng S,Patra D,et al.Linking microbial contamination to food spoilage and food waste:the role of smart packaging,spoilage risk assessments,and date labeling[J].Frontiers in Microbiology,2023,14:1198124.
[2] Snyder A B,Martin N,Wiedmann M.Microbial food spoilage:impact,causative agents and control strategies[J].Nature Reviews Microbiology,2024,22(9):528-542.
[3] Giles C,Lamont-Friedrich S J,Michl T D,et al.The importance of fungal pathogens and antifungal coatings in medical device infections[J].Biotechnology Advances,2018,36(1):264-280.
[4] Bonadonna L,Briancesco R,Semproni M.Microbiological inspections of different medical devices[J].Microchemical Journal,2018,136:283-286.
[5] Sandu A M,Chifiriuc M C,Vrancianu C O,et al.Healthcare-associated infections:the role of microbial and environmental factors in infection control--a narrative review[J].Infectious Diseases and Therapy,2025,14:933-971.
[6] Zhao Y,Xiong M,Huang Y,et al.A review of airborne microorganism transmission and control in household indoor air[J].Particuology,2025,97:143-153.
[7] Overgaard H J,Dada N,Lenhart A,et al.Integrated disease management:arboviral infections and waterborne diarrhoea[J].Bulletin of the World Health Organization,2021,99(8):583-592.
[8] Li Y,Dong T,Li Z,et al.Review of advances in electrospinning-based strategies for spinal cord regeneration[J].Materials Today Chemistry,2022,24:100944.
[9] Li H,Cai Q,Ming X,et al.Self-feeding needleless electrospinning of cross-linked nanofibrous materials for high-performance air filtration[J].Small,2025,21(33):2505585.
[10] Xu W,Sun K,Hou S,et al.Research progress of advanced polymer composite antibacterial materials based on electrospinning[J].European Polymer Journal,2025,222:113623.
[11] Li H,Chen X,Lu W,et al.Application of electrospinning in antibacterial field[J].Nanomaterials,2021,11(7):1822.
[12] Wang L,Xiong J,Liang F,et al.Green and facile fabrication of high-performance antibacterial nanofiber materials with low cytotoxicity using eggshell membrane hydrolysate[J].Materials & Design,2025,254:114031.
[13] Zheng L,Zhu Z,Pan L,et al.Polysaccharides and proteins as natural polymers for electrospun wound dressings:a review of healing potential,challenges,and crosslinking strategies[J].International Journal of Biological Macromolecules,2025,320:145960.
[14] Vidal P C,Shugulí M C,Guivier M,et al.PLA-and PHA-biopolyester-based electrospun materials:development,legislation,and food packaging applications[J].Molecules,2024,29(22):5452.
[15] Mustafa B D,Sakai T,Sato O,et al.Electrospun ibuprofen-loaded blend PCL/PEO fibers for topical drug delivery applications[J].Polymers,2024,16(13):1934.
[16] 张群华,范小平,刘媛,等.静电纺PU纳米纤维膜及其固定化酶的研究[J].应用化工,2021,50(7):1870-1874.
[17] Vieira T,Afonso F A,Correia C,et al.Electrospun poly(lactic acid) membranes with defined pore size to enhance cell infiltration[J].Heliyon,2024,10(16):e36091.
[18] Huang T W,Lin M,Lin M C,et al.Antibacterial wound dressings made of differently concentrated salvia miltiorrhiza bunge via electrospinning[J].Journal of Polymer Research,2023,30(8):321.
[19] Cheng Y W,Lin Y Y,Liu C L,et al.Zwitterionic functional layer modified electrospun polyurethane nanofiber membrane incorporating silver nanoparticles for enhanced antibacterial applications[J].Surface and Coatings Technology,2024,484:130865.
[20] Bombin A D J,Dunne N J,McCarthy H O.Electrospinning of natural polymers for the production of nanofibres for wound healing applications[J].Materials Science and Engineering:C,2020,114:110994.
[21] Sun F L,Zhao M Y,Li Y,et al.Research progress of electrospinning in food field:a review[J].Food Hydrocolloids,2025,158:110474.
[22] Gao M,Tang H,Zhu H.Advances in extraction,utilization,and development of chitin/chitosan and its derivatives from shrimp shell waste[J].Comprehensive Reviews in Food Science and Food Safety,2024,23(5):e70008.
[23] Wang Z H,Liu M H,Bu Q H,et al.Quaternary chitosan/polyvinyl alcohol/thymol electrospun nanofiber films integrated with deodorization,antibacterial and antioxidant properties for aquatic products packaging[J].Food Research International,2025,208:116270.
[24] Kenawy E R,Kamoun E A,Ghaly Z S,et al.Copper and fluorine-MOFs loaded-electrospun PVA/gelatin nanofibers for enhancing the antimicrobial activity of topical wound dressings:MOFs synthesis and spinning conditions optimization[J].Materials Chemistry and Physics,2025,332:130303.
[25] She P,Li S,Li X,et al.Photocatalytic antibacterial agents based on inorganic semiconductor nanomaterials:a review[J].Nanoscale,2024,16(10):4961-4973.
[26] Wang X,Liu S,Li M,et al.The synergistic antibacterial activity and mechanism of multicomponent metal ions-containing aqueous solutions against staphylococcus aureus[J].Journal of Inorganic Biochemistry,2016,163:214-220.
[27] Zhou Z,Li B,Liu X,et al.Recent progress in photocatalytic antibacterial[J].ACS Applied Bio Materials,2021,4(5):3909-3936.
[28] Samokhin Y,Varava Y,Diedkova K,et al.Electrospun chitosan/polylactic acid nanofibers with silver nanoparticles:structure,antibacterial,and cytotoxic properties[J].ACS Applied Bio Materials,2025,8(2):1027-1037.
[29] Zhang T,Guo Z,Huang Z,et al.Performance-enhanced oxygen vacancy-rich C-TiO2 nanofiber membranes for dual photocatalytic/bactericidal water treatment[J].Separation and Purification Technology,2025,377(P1):134169.
[30] Du R,Li X,Wu W,et al.Black phosphorus-doped Janus structured electrospun fibrous membrane with antibacterial properties for wound healing[J].Chemical Engineering Journal,2025,519:165605.
[31] Wang Y,Chen R,Li T,et al.Antimicrobial waterborne polyurethanes based on quaternary ammonium compounds[J].Industrial & Engineering Chemistry Research,2019,59(1):458-463.
[32] Shao Z,Kang G,Xie J,et al.Electrospun mutualism-inspired CA/CMA/PHMB ultrafine bimodal nanofibrous membrane for high-performance,antibacterial,and mosquito-repellent air filtration[J].Separation and Purification Technology,2023,327:124920.
[33] Prins C R,Billerbeck S.Small proteins and peptides conferring protection against antimicrobial compounds[J].Trends in microbiology,2025,33(6):586-602.
[34] Maleki Dizaj S,Sharifi S,Jahangiri A.Electrospun nanofibers as versatile platform in antimicrobial delivery:current state and perspectives[J].Pharmaceutical Development and Technology,2019,24(10):1187-1199.
[35] Zhang Y,Yang L,Dong Q,et al.Fabrication of antibacterial fibrous films by electrospinning and their application for Japanese sea bass (Lateolabrax japonicus) preservation[J].LWT,2021,149:111870.
[36] Batiha G E S,Hussein D E,Algammal A M,et al.Application of natural antimicrobials in food preservation:recent views[J].Food Control,2021,126:108066.
[37] Rao J,Chen B,McClements D J.Improving the efficacy of essential oils as antimicrobials in foods:mechanisms of action[J].Annual Review of Food Science and Technology,2019,10(1):365-387.
[38] Wu J,Liu S,Zhang M,et al.Coaxial electrospinning preparation and antibacterial property of polylactic acid/tea polyphenol nanofiber membrane[J].Journal of Industrial Textiles,2022,51(S2):1778S-1792S.
[39] 陈鹤鸣,胡娇,康花,等.聚氨酯/黑种草子伤口敷料的制备与性能表征[J].功能高分子学报,2024,37(2):148-156.
[40] 刘海磊,张国华,商大伟,等.医用静电纺纳米纤维材料的力学性能提升及其研究进展[J].棉纺织技术,2025,53(6):11-19.
[41] Korniienko V,Husak Y,Radwan-Pragłowska J,et al.Impact of electrospinning parameters and post-treatment method on antibacterial and antibiofilm activity of chitosan nanofibers[J].Molecules,2022,27(10):3343.
[42] Huang D,Si S Q,Chen Z,et al.Preparation,characterization and antibacterial evaluation of PLA/ZnO nanofiber membranes loaded with thymol by coaxial electrospinning[J].Journal of Drug Delivery Science and Technology,2025,110:107040.
[43] Wu Y,Zhang S,Yan Z,et al.Improvement of stress resistance of microencapsulated lactobacillus plantarum by emulsion electrospinning[J].Foods,2024,13(12):1897.
[44] Keskinkaya R,Yıldırım A,Çağlayan Ş,et al.Fabrication of multifunctional nanofiber mats by emulsion electrospinning of TPU/fish skin gelatin incorporating plant extract-based therapeutic oil for wound dressing applications[J].Macromolecular Materials and Engineering,2025,310(10):e00015.
[45] Lu J,Li Y,Zhang A,et al.Sustained release of ganoderma lucidum antitumor drugs using a sandwich structured material prepared by electrospinning[J].Journal of Drug Delivery Science and Technology,2021,64:102627.
[46] Koru Z E,Yesiltepe O,Guldu O K,et al.Development of mandelic acid-loaded electrospun nanofibers as a wound dressing material[J].Materials Chemistry and Physics,2025,343:131054.
[47] 魏子杰,孙静雯,高鹏宇,等.壳聚糖/明胶/氧化灵芝多糖纳米纤维膜的制备与性能表征[J].信息记录材料,2025,26(7):15-17,24.
[48] Pi S,Liu C,Zhang J,et al.Durable rapid self-disinfection,reusable protective clothing based on the Ag-Pd@MoS2 nanozyme with enhanced triple-mode synergistic antibacterial effect[J].ACS Applied Materials & Interfaces,2023,15(14):18032-18044.
[49] Wang T,Su E.Electrospinning meets food packaging:a promising pathway towards novel opportunities in food preservation[J].Food Packaging and Shelf Life,2024,41:101234.
[50] Cheng J,Li D,Mai Z,et al.In-situ electrospinning PVB/Camellia oil/ZnO-TiO2 nanofibrous membranes with synergistic antibacterial and degradation of ethylene applied in fruit preservation[J].Food Chemistry,2024,460:140629.
[51] Li D,Chen F,Dong Z,et al.Electrospun PLA/ZnO composite films:enhanced antibacterial properties and application in fresh chicken meat preservation[J].Food Packaging and Shelf Life,2025,49:101536.
[52] Yu Z,Fan T,Liu Y,et al.Efficient air filtration through advanced electrospinning techniques in nanofibrous materials:a review[J].Separation and Purification Technology,2024,349:127773.
[53] Shao W,Liu S,Wang K,et al.Using modified raw materials to fabricate electrospun,superhydrophobic poly(lactic acid) multiscale nanofibrous membranes for air-filtration applications[J].Separation and Purification Technology,2024,333:125872.
[54] Devi R,Kumar M,Singh J,et al.Electrospun nanofibers with antibacterial and antioxidant activities for air purification[J].ACS Applied Nano Materials,2025,8(11):5513-5526.
[55] Zeng J,Wu C,Wang S,et al.Development of high-throughput electrospun chitosan/PEO-CNC composite membranes with enhanced antibacterial and oil-water separation properties[J].International Journal of Biological Macromolecules,2025,303:140308.
基金资助
新疆维吾尔自治区大学生创新创业训练计划资助项目(X202513561128);新疆科技学院校级科研基金项目(2025-KYPT41)
PDF
