聚己内酯(PCL)作为一种可生物降解聚合物,是一种极具前景的生物基医用材料,但其低熔点和分解温度限制了实际应用。六方氮化硼(h-BN)是一种类石墨烯层状纳米材料,具有优异的润滑性和化学惰性。剥离后的氮化硼纳米片(BNNS)比h-BN粉末具有显著提高的比表面积。通过超声剥离h-BN制备BNNS,并采用共沉淀法合成不同比例的PCL:BNNS复合材料。该复合材料用于封装易挥发的茶树精油(TTO),实现长效缓释。形貌表征表明,BNNS的引入提高了TTO负载能力:块状复合材料的负载量较纯PCL分别增加6.77%、42.71%和44.42%,而薄膜复合材料的负载量提高29.25%、52.40%和30.23%。其中PCL:BNNS(100:7)薄膜表现出最优负载性能(24.75%)。缓释实验证实BNNS可有效延缓TTO释放,延长抑菌作用时间。抑菌评估验证了其对菌株的持续抑制作用,凸显了该复合材料控制抗菌剂释放的潜力。
Polycaprolactone (PCL),as a biodegradable polymer,is a promising bio-based medical material,but its low melting point and decomposition temperature limit its practical applications.Hexagonal boron nitride (h-BN) is a graphene-like layered nanomaterial with excellent lubricity and chemical inertness.Stripped boron nitride nanosheets (BNNS) have a significantly improved specific surface area than h-BN powder.In this study,BNNS was prepared by ultrasonic exfoliation of h-BN,and PCL:BNNS composites with different proportions were synthesized by co-precipitation.The composites were used to encapsulate volatile tea tree essential oil (TTO)to achieve sustained release.The morphological characterization showed that the introduction of BNNS increased the TTO loading capacity:the loading of block composites increased by 6.77%,42.71% and 44.42% compared with pure PCL,respectively,while the loading of thin film composites increased by 29.25%,53.40% and 30.23%,respectively.Among them,PCL:BNNS (100:7) film exhibited the optimal adsorption performance (24.75%).Sustained-release experiments confirmed that BNNS could effectively delay the release of TTO and prolong the antibacterial effect.Antibacterial evaluation validated their sustained inhibitory effect on strains,highlighting the composite's potential to control the release of antibacterial agents.
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基金资助
广州市重点研发计划项目(2023B03J1265);广东省重点领域研发计划项目(2023B0202080002);广东省大学生创新创业训练计划项目(S202411347041)
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