热响应PNIPAM水凝胶的制备及生物医学应用的研究进展

姜玉, 吴艳叶, 魏风军, 刘辉

化工新型材料 ›› 2026, Vol. 54 ›› Issue (2) : 12 -18.

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化工新型材料 ›› 2026, Vol. 54 ›› Issue (2) : 12-18. DOI: 10.19817/j.cnki.issn1006-3536.2026.03.020
专题:化工新材料在生物医学领域的应用研究进展

热响应PNIPAM水凝胶的制备及生物医学应用的研究进展

    姜玉, 吴艳叶, 魏风军, 刘辉
作者信息 +

Research progress on the preparation and biomedical application of thermoresponsive PNIPAM-based hydrogels

  • Jiang Yu, Wu Yanye, Wei Fengjun, Liu Hui
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文章历史 +
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摘要

热响应聚(N-异丙基丙烯酰胺)(PNIPAM)基水凝胶作为一种智能材料,由于低临界转变温度接近人体体温,在生物医学领域得到了广泛研究和应用。简要综述了PNIPAM基水凝胶的制备策略、性能改进方法及其在生物医学中的应用研究,探讨了目前PNIPAM基水凝胶发展面临的挑战,并提出了解决方案,为未来设计生产性能优异的PNIPAM基水凝胶提供参考。

Abstract

As an intelligent material,thermoresponsive poly (N-isopropylacrylamide) (PNIPAM)-based hydrogels have been widely studied and applied in the biomedical field due to their low critical transition temperature close to human body temperature.The preparation strategies,modification methods,and biomedical applications of PNIPAM-based hydrogels were reviewed.The current challenges and potential solutions of PNIPAM-based hydrogels were put forward in order to providing references for designing and producing PNIPAM-based hydrogels with higher performance in the future.

关键词

N-异丙基丙烯酰胺 / 热响应 / 水凝胶 / 设计策略 / 生物医学

Key words

N-isopropylacrylamide / thermoresponsive / hydrogel / design strategy / biomedicine

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热响应PNIPAM水凝胶的制备及生物医学应用的研究进展[J]. 化工新型材料, 2026, 54(2): 12-18 DOI:10.19817/j.cnki.issn1006-3536.2026.03.020

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基金资助

国家自然科学基金(51675162);河南科技大学博士启动基金(1348003)

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