随着我国人口进入负增长时代,老龄化问题愈发严峻。近10年来,阿尔兹海默症、帕金森综合征等老年群体多发疾病的发病率正逐年上升。神经递质浓度作为该类疾病的重要指标,在临床诊断中具有重要作用。电化学检测神经递质具有快捷、成本低、易小型化等优势,但同时也存在灵敏度低和抗干扰能力差等问题。金属-有机框架(MOF)材料由于超大的比表面积、可调的孔道结构以及配体的多样性,在构建高性能电化学传感界面时展现出独特优势。综述了MOF材料的合成方法以及MOF及其复合材料在神经递质电化学传感中的应用研究进展,并展望了MOF及其复合材料在神经递质电化学传感领域的发展趋势。
As China enters an era of negative population growth,the issue of population aging has become increasingly severe.Over the past decade,the incidence rate of age-related diseases prevalent among the elderly,such as Alzheimer's disease and Parkinson's syndrome,has been rising year by year.As a crucial indicator for such diseases,neurotransmitter concentration plays an important role in clinical diagnosis.Electrochemical detection of neurotransmitters offers advantages including fast response,low cost,and easy miniaturization.However,it also suffers from limitations like low sensitivity and poor anti-interference capability.Owing to their ultra-large specific surface area,tunable pore structure,and diverse ligands,metal-organic framework (MOF) materials exhibit unique advantages in constructing high-performance electrochemical sensing interfaces.This paper reviewed the synthesis methods of MOF materials,as well as the research progress in the application of MOF and their composites in neurotransmitter electrochemical sensing,and prospected the development trends of MOF and their composites in this field.
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基金资助
国家自然科学基金(22175057);河南省高等学校重点科研项目(24B1500101);河南省科技攻关项目(242102320101)
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