随着材料工程与生物工程的交叉融合,石墨烯类材料在生物医学领域的应用逐步扩展。其高比表面积和易于功能化的表面结构,使其在药物递送和治疗癌症等技术领域具有重要影响。可控的界面润湿性和较高的吸光度则使石墨烯能用于生物控冰及光热复苏。而石墨烯固有的高灵敏电化学响应特性,使其在生物传感界面构建中展现出卓越的分子识别效能。同时,石墨烯独特的机械性能和可控的纤维状结构在组织工程和再生医学等领域也展现出广阔的应用前景。系统阐述了石墨烯及其衍生物材料的来源与分类,研究了其在生物相容性、药物传递、癌症治疗、生物控冰、生物传感及再生医学等领域的具体应用进展。最后,介绍了石墨烯类生物材料未来可能面临的挑战。
With the cross-fertilization of materials engineering and bioengineering,the application of graphene-based materials in the biomedical field has grown progressively.Their high specific surface area and easy-to-functionalize surface structure make them influential in technical fields such as drug delivery and cancer treatment.Controllable interfacial wettability and high absorbance enable graphene to be used for biocontrol ice and photothermal resuscitation.Graphene's inherent highly sensitive electrochemical response allows it to exhibit excellent molecular recognition efficiency in the construction of biosensing interfaces.Meanwhile,the unique mechanical properties and controllable fiber-like structure of graphene also show broad application prospects in the fields of tissue engineering and regenerative medicine.This review systematically described the relationship between the types of graphene and its derivative materials,and investigated the progress of their specific applications in the fields of biocompatibility,drug delivery,cancer therapy,biocontrolled ice,biosensing,and regenerative medicine.Finally,possible future challenges for graphene-based biomaterials were presented.
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基金资助
重庆市研究生联合培养基地项目(JDLHPYJD2020031);山东省科技型中小企业创新能力提升工程项目(2024TSGC0948)
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