自愈合聚合物水凝胶是一种由聚合物交联网络与水组成的可再生的软组织材料。因其具有良好的生物相容性、高含水量、类细胞外机制、稳定性高、可自我修复等优点,被广泛应用于组织工程、伤口敷料和药物释放等领域。然而,其快速自修复性能和足够的机械强度之间存在不相容性,如何实现两者的平衡是目前面临的主要挑战。对自愈合聚合物水凝胶的自愈合机制进行了全面总结,并对自愈合水凝胶在生物医学领域的应用进行了总结与展望。
Self-healing hydrogel is a kind of renewable soft tissue material composed of polymer crosslinked network and water.Because of its good biocompatibility,high water content,extracellular mechanism,high stability,self-healing and other advantages,it is widely used in the fields of tissue engineering,wound dressing and drug release system.However,there is incompatibility between the fast self-healing properties of self-healing hydrogel and its adequate mechanical strength,and how to balance between the two is still a primary challenge currently faced.The self-healing mechanisms of hydrogels was comprehensively summarized,and the application of self-healing hydrogels in the biomedical field was summarized and prospected.
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基金资助
安徽工业大学青年基金资助项目(R019100271)
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