氟化硼二吡咯(BODIPY)作为一种结构可调的光敏剂,凭借优异的光物理和化学特性,在生物医学领域得到广泛应用。作为卟啉类荧光染料的近亲,BODIPY具备优良的光学成像能力和光学治疗效果。然而,水溶性不佳、生物相容性较差,以及在水相和固态中容易发生聚集猝灭等问题,严重制约了BODIPY在生物医学领域的进一步应用。近年来,基于BODIPY的新型材料成为研究热点,为拓展其生物医学应用范围带来了新的契机,展现出巨大的潜力。综述了BODIPY新型材料在荧光传感、生物成像、光动力治疗和光热治疗等领域的应用进展,并展望了其未来的研究方向。
Boron dipyrromethene (BODIPY) is a structurally tunable photosensitizer.It is widely used in the biomedical field due to its excellent photophysical and chemical properties.As a close relative family of porphyrin fluorescent dyes,it has good optical imaging ability and optical therapeutic effect.However,its poor water solubility and biocompatibility,as well as the tendency to aggregate and quenching in water phase and solid state,have seriously hindered its application in the biomedical field.In recent years,the research of new materials based on BODIPY has become a hot topic,expanding the scope of its biomedical applications and showing great potential.The application progress of novel BODIPY materials in fluorescence sensing,bioimaging,photodynamic therapy,and photothermal therapy was reviewed,and the future research directions were also prospected.
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基金资助
河南省科技攻关项目(242102231037);河南省郑州轻工业大学博士启动基金(2021BSJJ010)
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