The salicylic aldehyde derivative ligand,3,5-dibromosalicylaldehyde-o-phenylenediamine (H2L),and its three transition systems Ni(Ⅱ),Cu(Ⅱ),Zn(Ⅱ) metal complexes were synthesized.The structures of the ligand and complexes were characterized by 1H-NMR,MS and FT-IR and elemental analysis.The thermal stability of complexes was investigated.The TG-DTG tests showed that the three complexes had good thermal stability.The photophysical properties of the complexes were studied by UV-Vis absorption spectroscopy,fluorescence excitation and emission spectra and DFT calculations.Among them,the ZnL·H2O complexes' energy band structure model was constructed and its optical band gap was obtained to be 2.62eV.At the same time,the ligand and its metal complexes were also screened against S.aureus,E.coli and E.herbicola.The antibacterial screening data indicated that both ligand and complexes exhibited certain antibacterial effects,and the antibacterial activity of the complexes were better than that of the ligand.Metal elements were important factors affecting the antibacterial activity of the complexes.Moreover,ZnL·H2O had low cytotoxicity and was successfully applied in HeLa cell tracing and imaging.
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基金资助
国家自然科学基金地区科学基金项目(82460364);国家自然科学基金面上项目(81901906);国家重点研发计划项目(2021YFA0910000);广西重点研发计划项目(2023AB01140);桂北特色药资源研究中心项目(20181102004);中国科学院重大仪器项目(ZDKYYQ20220008);深圳市孔雀团队项目(KQTD20210811090115019)
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