区别于传统的高分子材料,聚氨酯具有微相分离结构,赋予其优良的性能调控能力,因而可通过不同的改性方法调节分子链的结构得到所需性能的聚氨酯复合材料。主要介绍了近年来医用聚氨酯的两大改性方法,一是以不同结构的多元醇作为软段结合不同的异氰酸酯或非异氰酸酯制备聚氨酯,使其结构多变,性能多样。二是通过添加填料对聚氨酯进行改性,在原有的性能基础上增加抗菌、抗氧化、刺激组织再生等额外的性能,提高材料的实际应用性。还介绍了聚氨酯在生物医学领域的具体应用,最后对生物医用聚氨酯材料的改性方法及应用进行了展望和总结。
Distinguished from traditional polymer materials,polyurethane has a microphase separation structure,which endows it with the excellent ability to adjust performance,and thus the structure of the molecular chain can be adjusted by different modification methods to obtain polyurethane composites with the required properties.Two main modification methods of medical polyurethane in recent years were introduced.The first involved using polyols with different structures as soft segments and combining with different isocyanates or non-isocyanates to prepare polyurethanes,so that their structures and properties were varied.The second method was adding fillers to further modify the existing structure of polyurethane,so as to increase additional properties such as antibacterial,antioxidant and tissue regeneration on the basis of the original properties,improving the practicality of the material.The article also introduced the specific application of polyurethane in the biomedical field.Finally,the modification methods and applications of biomedical polyurethane materials were prospected and summarized.
[1] Sophie W,Av'erous L.Biobased polyurethanes for biomedical applications[J].Bioactive Materials,2021,6(4):1083-1106.
[2] 邵树仁,吴和成,唐林,等.医用聚氨酯材料的研究及应用进展[J].聚氨酯工业,2022,37(2):1-6.
[3] Sternberg J,Sequerth O,Pilla S.Green chemistry design in polymers derived from lignin:review and perspective[J].Progress in Polymer Science,2021,113:101344.
[4] Bayer O.Das Di-lsocganat-poluadditionsverfahren (Polyurethane)[J].Angew Chem,1947,59:257-272.
[5] 刘美琴,赵玉梅,石红翠,等.非异氰酸酯聚氨酯的合成与功能性研究进展[J].高分子通报,2024(11)1570-1580.
[6] Nierzwicki W,Wysocka E.Microphase separation and properties of urethane elastomers[J].Journal of Applied Polymer Science,1980,25(5):739-746.
[7] Wu L,Guo J,Zhao S.Flame-retardant and crosslinking modification of MDI-based waterborne polyurethane[J].Polymer Bulletin,2016,74(6):2099-2116.
[8] Gomez C M,Gutierrez D,Asensio M,et al.Transparent thermoplastic polyurethanes based on aliphatic diisocyanates and polycarbonate diol[J].Journal of Elastomers & Plastics,2016,49(1):77-95.
[9] Sun W,Liu X,Liu K,et al.Paradoxical filler size effect on composite wear:filler-matrix interaction and its tribochemical consequences[J].Tribology Letters,2020,68(4):131-150.
[10] Khakbaz H,Ruberu K,Kang L,et al.3D printing of highly flexible,cytocompatible nanocomposites for thermal management[J].Journal of Materials Science,2021,56(10):6385-6400.
[11] M'Bengue M S,Mesnard T,Chai F,et al.Evaluation of a medical grade thermoplastic polyurethane for the manufacture of an implantable medical device:the impact of FDM 3D-printing and gamma sterilization[J].Pharmaceutics,2023,15(2):456-469.
[12] Ruairí P B,Anthony W,Andrew P D.Application of modified amino acid-derived diols as chain extenders in the synthesis of novel thermoplastic polyester-urethane elastomers[J].ACS Sustainable Chemistry & Engineering,2017,5(8):6902-6909.
[13] 全晓静,王晶,谢丹红,等.胆碱能信号通路及离子通道介导精氨酸对结肠平滑肌收缩的促进作用[J].中国药理学通报,2024(8):1532-1538.
[14] Zou F,Wang Y,Zheng Y,et al.A novel bioactive polyurethane with controlled degradation and L-Arg release used as strong adhesive tissue patch for hemostasis and promoting wound healing[J].Bioactive Materials,2022,17(9):471-487.
[15] Li S,Zhang Y,Ma X,et al.Antimicrobial lignin-based polyurethane/Ag composite foams for improving wound healing[J].Biomacromolecules,2022,23(4):1622-1632.
[16] Stephanie E K,Alzagameem A,Jessica R,et al.Antimicrobial activity of lignin-derived polyurethane coatings prepared from unmodified and demethylated lignins[J].Coatings,2019,9(8):494-511.
[17] Xu X,Chao Y,Ma X,et al.A photothermally antibacterial Au@Halloysite nanotubes/lignin composite hydrogel for promoting wound healing[J].International Journal of Biological Macromolecules,2023,12:128704.
[18] Chao Y,Yu S,Zhang H,et al.Architecting lignin/poly(vinyl alcohol) hydrogel with carbon nanotubes for photothermal antibacterial therapy[J].ACS Applied Bio Materials,2023,6:1525-1535.
[19] Li S,Zhang Y,Ma X,et al.Antimicrobial lignin-based polyurethane/Ag composite foams for improving wound healing[J].Biomacromolecules,2022,23:1622-1632.
[20] An X P,Chen J H,Li Y D,et al.Rational design of sustainable polyurethanes from castor oil:towards simultaneous reinforcement and toughening[J].Science China Materials,2018,61(7):993-1000.
[21] Zhong Y Y,Zhang T,Zhang W,et al.Antibacterial castor oil-based waterborne polyurethane/gelatin films for packaging of strawberries[J].Food Packaging and Shelf Life,2023,36:101055.
[22] Villada Y,Inciarte H,Gomez C,et al.Alkyd-urethane resins based on castor oil:synthesis,characterization and coating properties[J].Progress in Organic Coatings,2023,180:107556.
[23] He X Y,Sun A,Li T,et al.Mussel-inspired antimicrobial gelatin/chitosan tissue adhesive rapidly activated in situ by H2O2/ascorbic acid for infected wound closure[J].Carbohydrate Polymers,2020,247(20):116692-116737.
[24] Liu Y,Zou Y,Wang J,et al.A novel cationic waterborne polyurethane coating modified by chitosan biguanide hydrochloride with application potential in medical catheters[J].Journal of Applied Polymer Science,2020,138(17):1-13.
[25] 陈亚萍,黄昀巍,张媛,等.共轭亚油酸对产蛋后期蛋鸡生产性能、生化指标及抗氧化性能的影响[J].西北农林科技大学学报(自然科学版),2024(10):1-8.
[26] Tran N,Le A,Ho M,et al.Polyurethane/polycaprolactone membrane grafted with conjugated linoleic acid for artificial vascular graft application[J].Science and Technology of Advanced Materials,2020,21(1):56-66.
[27] Wang W,Zhou Z,Liu N,et al.Improving biocompatibility of polyester fabrics through polyurethane/gelatin complex coating for potential vascular application[J].Polymers (Basel),2022,14(5):989-1007.
[28] Xie X,Li D,Chen Y,et al.Conjugate electrospun 3D gelatin nanofiber sponge for rapid hemostasis[J].Advanced Healthcare Materials,2021,10(20):2100918-2100931.
[29] Novoselov K S,Geim A K,Morozov S V,et al.Two-dimensional gas of massless Dirac fermions in graphene[J].Nature,2005,438(7065):197-200.
[30] Lee T H,Yen C T,Hsu S H.Preparation of polyurethane-graphene nanocomposite and evaluation of neurovascular regeneration[J].ACS Biomaterials Science & Engineering,2020,6(1):597-609.
[31] Jo S B,Erdenebileg U,Dashnyam K,et al.Nano-graphene oxide/polyurethane nanofibers:mechanically flexible and myogenic stimulating matrix for skeletal tissue engineering[J].Journal of Tissue Engineering,2020,11:73141.
[32] Sheikh F A,Macossay J,Cantu T,et al.Imaging,spectroscopy,mechanical,alignment and biocompatibility studies of electrospun medical grade polyurethane (Carbothane 3575A) nanofibers and composite nanofibers containing multiwalled carbon nanotubes[J].Journal of the Mechanical Behavior of Biomedical Materials,2015,41(14):189-198.
[33] Jinitha T V,Hussan K P S,Shahin T M,et al.The interplay between the fragility and mechanical properties of styrene-butadiene rubber composites with unmodified and modified sago seed shell powder[J].Journal of Applied Polymer Science,2020,49180:1-13.
[34] Sahar H,Esmaeili A.Synthesize of polyurethane/chitosan/Vicia ervilia protein/gelatin/heparin-coated Astragalus gossypinus scaffold for cardiovascular tissue engineering[J].Process Biochemistry,2022,122:205-213.
[35] Liu J W,Cui T T,Xu X W,et al.Robust alcohol soluble polyurethane/chitosan/silk sericin (APU/CS/SS) nanofiber scaffolds toward artificial skin extracellular matrices via microfluidic blow-spinning[J].Advanced Fiber Materials,2022,22(227):1-13.
[36] Amiri F,Babaei M,Jamshidi N,et al.Fabrication and assessment of a novel hybrid scaffold consisted of polyurethane-gellan gum-hyaluronic acid-glucosamine for meniscus tissue engineering[J].International Journal of Biological Macromolecules,2022,203:610-22.
[37] Zheng M,Guo J,Li Q,et al.Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering[J].Bioactive Materials,2021,6(2):404-419.
[38] Yang R,Liu W,Wang A,et al.Shape memory polyurethane potentially used for vascular stents with water-induced stiffening and improved hemocompatibility[J].Journal of Materials Chemistry B,2022,10(43):8918-8930.
[39] Krieter P A,Ziegler D M,Hill K E,et al.Studies on the biliary efflux of gsh from rat liver due to the metabolism of aminopyrine[J].Biochemical Pharmacology,1985,34(7):955-960.
[40] Lee D K,Kim H S,Kim K S,et al.The effect on porcine bile duct of a metallic stent covered with a paclitaxel-incorporated membrane[J].Gastrointestinal Endoscopy 2005,61(2):296-301.
[41] Jiang X,Xiong X,Lin Y,et al.A composite scaffold fabricated with an acellular matrix and biodegradable polyurethane for the in vivo regeneration of pig bile duct defects[J].Acta Biomaterialia,2022,150:238-253.
[42] 郭利明,李子林,段维勋,等.新型聚氨酯心脏瓣膜的组织相容性试验[J].心脏杂志,2010,22(4):592-594.
[43] Dehghani F,Khorasani M T,Movahedi M.Fabrication of polyurethane-heparinized carbon nanotubes composite for heart valves application[J].Materials Chemistry and Physics,2022,280:125819.
[44] Guo F,Han R,Ying J,et al.Bioinspired polymeric heart valves derived from polyurethane and natural cellulose fibers[J].Journal of Materials Science & Technology,2023,144(9):178-187.
[45] Shaabani A,Sedghi R,Motasadizadeh H,et al.Self-healable conductive polyurethane with the body temperature-responsive shape memory for bone tissue engineering[J].Chemical Engineering Journal,2021,411:12844.
[46] Nicola C N,Claudio R,Federica B,et al.An osteosarcoma model by 3D printed polyurethane scaffold and in vitro generated bone extracellular matrix[J].Cancers (Basel),2022,14(8):2003-2023.
[47] He Y,Wang X,He Y,et al.A bioinspired Janus polyurethane membrane for potential periodontal tissue regeneration[J].Journal of Materials Chemistry B,2022,10(14):2602-2616.
[48] Sebastião V.U,Valentina C,Giovanni P,et al.Electrospun fibroin/polyurethane hybrid meshes:manufacturing,characterization,and potentialities as substrates for haemodialysis arteriovenous grafts[J].Journal of Biomedical Materials Research Part B:Applied Biomaterials,2019,107(3):807-817.
[49] Zhang Z,Wang L,Liu J,et al.Water-triggered segment orientation of long-lasting anti-biofouling polyurethane coatings on biomedical catheters via solvent exchange strategy[J].Small,2023,19(43):2304379.
基金资助
国家自然基金面上项目(52173086);国家重点研发计划项目(2017YFE0102300);宁波市重点研发计划项目(2022Z139)
PDF
