为了获得具有纯海绵结构且具有良好拦截性能的聚偏氟乙烯生物分离膜,系统考察铸膜液温度、凝固浴温度、空气湿度、空气停留时间对分离膜纯水通量和静脉注射人免疫球蛋白(IVIG)溶液的透过率、通量、载量的影响。结果表明:在铸膜液温度为65℃,空气湿度为85%,空气停留时间为10s,凝固浴温度为45℃,凝固浴停留时间为3min的条件下制备出的聚偏氟乙烯膜具有表面开孔均匀、断面呈现全海绵结构的特点,该膜的纯水通量较大,耐压性能较好,IVIG透过率较高,IVIG通量和载量较大,并且对20nm纳米金的截留率较高,综合性能较好。
In order to obtain polyvinylidene fluoride bio-separation membranes with a pure sponge structure and good interception performance,the effects of casting liquid temperature,solidification bath temperature,air humidity and air residence time on the pure water flux of the separation membrane and the permeability,flux and loading capacity of intravenous immunoglobulin (IVIG) solution were systematically investigated.The results showed that the polyvinylidene fluoride membrane prepared under the conditions of casting liquid temperature of 65℃,air humidity of 85%,air residence time of 10s,solidification bath temperature of 45℃ and solidification bath residence time of 3min had the characteristics of uniform surface openings and full sponge cross-sectional structure.The separation membrane had a higher pure water flux,better pressure resistance,higher IVIG transmittance,larger IVIG flux and loading capacity,and higher retention rate of 20nm gold nanoparticles,indicating excellent comprehensive performance.
[1] 崔帅军.制药分离技术在制药工程中的分析研究[J].大众标准化,2024(9):47-49.
[2] Chang H H,Chang L K,Yang C D,et al.Effect of solvent on the dipole rotation of poly(vinylidene fluoride) during porous membrane formation by precipitation in alcohol baths[J].Polymer,2017,115:164-175.
[3] Yang H R,Huang Y H,Wang C F,et al.Green fabrication of PVDF superhydrophobic membranes u-sing a green solvent triethyl phosphate(TEP) for membrane distillation[J].Desalination,2023,566:116934.
[4] 吕德鹏,杨玥.膜分离技术在生物制药中的应用[J].山西化工,2022,42(5):25-28.
[5] 汪子涵.膜分离技术在制药工业中的应用[J].科技创新导报,2020(1):69-70.
[6] 牛红男,王建明,黄洁萍,等.聚偏氟乙烯微滤膜的制备及相转化工艺参数的优化[J].集成技术,2024,13(4):117-130.
[7] 石川,刘潇,汪效祖,等.共溶剂对聚酰亚胺气体分离膜结构与性能的影响研究[J].化工新型材料,2016,44(5):166-168,172.
[8] Zhang R W,Tang W Y,Gao H F,et al.In-situ construction of uperhydrophobic PVDF membrane via NaCl-H2O induced polymer incipient gelation for membrane distillation[J].Separation and Purification Technology,2021,274:117762.
[9] Aldo B,Antonio C,Camilla C,et al.Novel hydrophobic PVDF membranes prepared by nonsolvent in-duced phase separation for membrane distillation[J].Journal of Membrane Science,2020,19(31):2028-2029.
[10] 徐小洁,于孟超,王钰,等.NIPS法疏水PVDF膜的结构与性能调控研究进展[J].膜科学与技术,2024,44(1):147-156,178.
[11] 魏永,赵威,江晓栋,等.PVDF超滤膜的制备影响因素研究[J].化工新型材料,2017,45(9):114-120.
[12] Frappa M,Driolia E,Macedonio F,et al.Hyflon/PVDF membranes prepared by NIPS and TIPS:Co-mparison in MD performance[J].Separation and Purification Technology,2020,23(5):1-9.
[13] 王志英,吴晓君,刘启东,等.环境相对湿度对高疏水性PVDF膜结构与性能的影响[J].功能材料,2013,44(16):2320-2323,2328.
[14] 沈江南,蒋婷婷,陈永盛,等.制膜条件对PVDF疏水微孔膜的结构和性能的影响[J].浙江工业大学学报,2011,39(6):591-595.
[15] 刘亚芳,李冠军,罗坚,等.实验设计法优化高浓度静注入免疫球蛋白制剂的处方[J].中国生物制品学杂志,2020,33(4):445-448,454.
[16] 吕佳洋,宋宏臣,王建明,等.不同结构的聚醚砜膜过滤阻力分析及耐碱性能研究[J].化工新型材料,2024,52(1):258-263.
基金资助
广东省重点领域研发计划项目(2023A1111030001);中科院科技服务网络计划项目(STS-HP-202205);深圳市科技计划可持续发展专项项目(KCXFZ20201221173402006);广州市南沙区高端领军人才创新团队科技项目(2020年度)
PDF
