壳聚糖因具有良好的生物降解性和生物相容性,成为生物医用水凝胶的理想基体材料。然而,壳聚糖基水凝胶在物理损伤后易断裂失效。壳聚糖基自愈合水凝胶利用动态化学键的可逆解离-重构自主修复网络裂纹,从而维持水凝胶结构的完整性和初始功能,延长材料的使用寿命。综述了壳聚糖与不同天然聚合物或合成聚合物复合的自愈合水凝胶的最新研究进展,进一步讨论了其在医用伤口敷料、智能生物传感器、细胞培养及组织工程支架等生物医用材料领域的应用。针对壳聚糖基自愈合水凝胶的研究现状,对其未来向智能化、绿色安全、多功能化和便携化发展以适应更广泛的应用场景进行了展望。
Chitosan is an ideal polymer matrix for the preparation of biomedical hydrogels due to its excellent biodegradability and biocompatibility.However,most chitosan-based hydrogels are prone to fracture and failure after physical damage.Reversible dissociation-reconstruction of dynamic chemical bonds are fabricated to repair network cracks autonomously in chitosan-based self-healing hydrogels,therefore the structural integrity and initial function of the hydrogels are maintained and the service life of the material is extended.In this paper,the latest research progress on chitosan-based self-healing hydrogels developed by compositing chitosan with other natural or synthetic polymers was reviewed,and their applications in the fields of biomedical materials such as medical wound dressings,intelligent biosensors,cell culture,and tissue-engineered scaffolds were further discussed.In view of the research status of chitosan-based self-healing hydrogels,the future development of intelligent,green and safe,multifunctional,and portable hydrogels was prospected to adopt broader application situations.
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基金资助
国家自然科学基金项目(22178242,51703152);山西省自然科学基金资助项目(20210302124101,202203021221093)
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