化工新型材料

化工新型材料 ›› 2025, Vol. 53 ›› Issue (1) : 33-37. DOI: 10.19817/j.cnki.issn1006-3536.2025.01.027

综述与专论

金属氧化物型复合纳米材料的制备及应用

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Preparation and application of metal oxide-based composite nanomaterials

Xiu Mengting, Zheng Zhiyu, Wang Tong, Zhu Limin

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Received		Published
2023-11-29		2025-01-20
Issue Date	Revised Date
2025-01-17	2023-11-29

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摘要

首先以乙酰丙酮铁[Fe(C₅H₇O₂)₃,98%]、乙酰丙酮铜[Cu(C₅H₇O₂)₂,97%]、二缩三乙二醇(TEG)为原料制备小型双金属氧化物纳米颗粒(CuFe₂O₄)。小型双金属氧化物纳米颗粒(CuFe₂O₄)通过静电吸附作用负载在过氧化镁(MgO₂)纳米片上以形成金属氧化物型复合纳米材料(CuFe₂O₄@MgO₂)。该复合纳米材料在肿瘤酸性条件下能产生大量高毒性的羟基自由基(·OH),对肿瘤细胞有较大的损伤作用。采用透射电子显微镜(TEM)、X射线光电子能谱技术、Zeta电位等手段对复合纳米材料进行表征。结果表明:CuFe₂O₄纳米颗粒分布在过氧化镁(MgO₂)纳米片的表面,同时结合Zeta电位等表征证明该复合纳米材料的成功制备。体外细胞实验证明该复合纳米材料具备抗肿瘤治疗效果。

Abstract

First,small bimetallic oxide nanoparticles (CuFe₂O₄) were prepared from iron acetylacetonate [Fe(C₅H₇O₂)₃,98%],copper acetylacetonate [Cu(C₅H₇O₂)₂,97%],and triethylene glycol (TEG).The small bimetallic oxide nanoparticles (CuFe₂O₄) were loaded on magnesium peroxide (MgO₂) nanosheets by electrostatic adsorption to form metal oxide-based composite nanomaterials (CuFe₂O₄@MgO₂).The composite nanomaterials could produce a large number of highly toxic hydroxyl radicals (·OH) under acidic conditions in tumors,which had a large damaging effect on tumor cells.Transmission electron microscopy (TEM),XPS spectroscopy,and zeta potential were used to characterize the composite nanomaterials.The results showed that CuFe₂O₄ nanoparticles were distributed on the surface of magnesium peroxide (MgO₂) nanosheets,and zeta potential measurements confirmed the successful preparation of this composite nanomaterial.In vitro cellular experiments demonstrated that the composite nanomaterials possessed anti-tumor therapeutic effects.

关键词

金属氧化物 / 静电吸附作用 / 活性氧 / 肿瘤治疗

Key words

metal oxides / electrostatic adsorption / reactive oxygen species / tumor therapy

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金属氧化物型复合纳米材料的制备及应用[J]. 化工新型材料, 2025, 53(1): 33-37 DOI:10.19817/j.cnki.issn1006-3536.2025.01.027

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