采用自制聚醚砜医用分离膜,考察不同孔径预过滤膜、操作压力、静脉注射人免疫球蛋白(IVIG)溶液的浓度、pH对静脉注射人免疫球蛋白(IVIG)溶液通量、载量、透过率以及透过衰减情况的影响。结果表明,制备的聚醚砜膜具有表面开孔均匀、断面呈现梯度结构的全海绵结构分离膜;在一定分离条件下,使用孔径较小的膜进行预过滤、提高操作压力能有效减缓膜孔堵塞,提高聚醚砜分离膜效率;使用较低浓度IVIG溶液能防止过早出现浓差极化,减少聚醚砜分离膜分离阻力,而过高的pH会导致蛋白结构、形态的改变,分离效率下降。
The effects of prefiltration membrane with different pore size,operating pressure,concentration of intravenous human immunoglobulin (IVIG) solution,and pH value on the flux,load,transmittance and attenuation of IVIG solution were investigated by using homemade polyether sulfone medical separation membranes.The results showed that the prepared polyether sulfone membranes had a whole sponge structure with uniform surface openings and a gradient cross-section structure.Under certain separation conditions,using the membrane with small pore size for pre-filtration and increasing the operating pressure could effectively reduce the pore plugging and improve the separation efficiency of polyether sulfone membrane.The use of lower concentration IVIG solution could prevent premature concentration polarization and reduce the separation resistance of polyether sulfone separation membrane,while too high pH value could lead to the change of protein structure and morphology,and decrease the separation efficiency.
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基金资助
广东省重点领域研发计划(2023A1111030001);广州市基础与应用基础研究项目(202201011763);深圳市科技计划可持续发展专项(KCXFZ20201221173402006);中科院科技服务网络计划项目(STS-HP-202205)
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