细菌是引起慢性传染病和感染的主要原因。用抗生素杀灭细菌、消除感染是当今普遍使用的有效医疗手段,但是抗生素的滥用和误用导致越来越多的细菌出现耐药性。此外,现有给药方式常导致大量药物难以到达作用位点,造成药效浪费。在应对抗菌困境的各类策略中,抗菌纳米材料已成为一种被广泛认可的新兴方法。沸石咪唑酯骨架-8(ZIF-8)是一种在连接节点可生长药物的金属-有机骨架材料,因具有生物相容性好、结构稳定、pH响应特性及其靶向给药且减少细菌耐药性产生的能力等特点,成为目前研究较为广泛的抗菌方式之一。同时,大量研究表明,ZIF-8有利于保持药物活性,具有潜在的临床抗菌应用可能。综述了ZIF-8的抗菌机理、在抗菌方面的应用及研究进展,并对该领域未来发展中面临的挑战和前景进行了总结与展望。
Bacteria are a major cause of chronic infectious diseases and infections.Using antibiotics is the most commonly used method to kill bacteria and eliminate infection,but the abuse and misuse of antibiotics have led to increasing drug-resistance bacteria.In addition,the existing drug delivery methods often make it difficult for drugs to reach the action site,resulting in a waste of drug efficacy.Among various strategies to address the antibacterial dilemma,antibacterial nanomaterials have become a widely recognized emerging method.Zeolite imidazole ester skeleton material-8 (ZIF-8) is a metal-organic skeleton material that can grow drugs at connecting nodes,and has become one of the extensively studied antibacterial methods due to its good biocompatibility,structural stability,pH-responsive property,targeted drug delivery,and the ability to reduce the emergence of bacterial drug resistance.At the same time,a large number of studies found that ZIF-8 is favorable for maintaining drug activity and has a potential for clinical antibacterial applications.Therefore,this paper reviewed the antibacterial mechanism,applications and research progress of ZIF-8 in the antibacterial field.It also summarized the challenges and prospects for future development in this field.
[1] Khatoon Z,McTiernan C D,Suuronen E J,et al.Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention[J].Heliyon,2018,4(12):1067.
[2] Cao G H,Yan J H,Ning X X,et al.Antibacterial and antibiofilm properties of graphene and its derivatives[J].Colloid Surface B,2021,200:111588.
[3] Wu B Y,Fu J T,Zhou Y X,et al.Metal-organic framework-based chemo-photothermal combinational system for precise,rapid,and efficient antibacterial therapeutics[J].Pharmaceutics,2019,11(9):463.
[4] Abdelhamid H N.Zeolitic imidazolate frameworks (ZIF-8) for biomedical applications:a review[J].Curr Med Chem,2021,28(34):7023-7075.
[5] Cai W,Chu C C,Liu G,et al.Metal-organic framework-based nanomedicine platforms for drug delivery and molecular imaging[J].Small,2015,11(37):4806-4822.
[6] Taheri M,Ashok D,Sen T,et al.Stability of ZIF-8 nanopowders in bacterial culture media and its implication for antibacterial properties[J].Chem Eng J,2020,413:127511.
[7] Mohanta G C,Pandey S K,Maurya I K,et al.Synergistic antimicrobial activity in ampicillin loaded core-shell ZnO@ZIF-8 particles[J].Chemistryselect,2019,4(41):12002-12009.
[8] Bagchi D,Bhattacharya A,Dutta T,et al.Nano MOF entrapping hydrophobic photosensitizer for dual-stimuli-responsive unprecedented therapeutic action against drug-resistant bacteria[J].ACS Appl Bio Mater,2019,2(4):1772-1780.
[9] Xiao Y,Xu M R,Lv N,et al.Dual stimuli-responsive metal-organic framework-based nanosystem for synergistic photothermal/pharmacological antibacterial therapy[J].Acta Biomater,2021,122:291-305.
[10] Peng D,Liu G H,He Y,et al.Fabrication of a pH-responsive core-shell nanosystem with a low-temperature photothermal therapy effect for treating bacterial biofilm infection[J].Biomater Sci,2021,9(22):7483-7491.
[11] Soomro N A,Wu Q,Amur S A,et al.Natural drug physcion encapsulated zeolitic imidazolate framework,and their application as antimicrobial agent[J].Colloid Surface B,2019,182:110364.
[12] Xu Y H,Fang Y,Ou Y J,et al.Zinc metal-organic framework@chitin composite sponge for rapid hemostasis and antibacterial infection[J].ACS Sustainable Chem Eng,2020,8(51):18915-18925.
[13] Ravinayagam V,Rehman S.Zeolitic imidazolate framework-8 (ZIF-8) doped TiZSM-5 and mesoporous carbon for antibacterial characterization[J].Saudi J Biol Sci,2020,27(7):1726-1736.
[14] Tao B L,Zhao W K,Lin C C,et al.Surface modification of titanium implants by ZIF-8@Levo/LBL coating for inhibition of bacterial-associated infection and enhancement of in vivo osseointegration[J].Chem Eng J,2020,390:124621.
[15] Cai Y,Guan J W,Wang W,et al.pH and light-responsive polycaprolactone/curcumin@ZIF-8 composite films with enhanced antibacterial activity[J].J Food Sci,2021,86(8):3550-3562.
[16] Gallis D F S,Butler K S,Agola J O,et al.Antibacterial countermeasures via metal-organic framework supported sustained therapeutic release[J].ACS Appl Mater Interfaces,2019,11(8):7782-7791.
[17] Esfahanian M,Ghasemzadeh M A,Razavian S M H.Synthesis,identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity[J].Artif Cell Nanomed B,2019,47(1):2024-2030.
[18] Ahanger A M,Kumar S,Kain D,et al.Nanoscale zeolitic imidazolate framework-8 encapsulates crude extract of ajuga bracteosa wall ex.Benth and enhanced their antibacterial efficiency[J].Inorg Chem Commun,2021,133:108940.
[19] Ahmed S A,Hasan M N,Bagchi D,et al.Nano-MOFs as targeted drug delivery agents to combat antibiotic-resistant bacterial infections[J].Roy Soc Open Sci,2020,7(12):200959.
[20] Luo D,Wang C,Tong Y,et al.An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment[J].RSC Adv,2020,10(13):7360-7367.
[21] Yang J,Liu C L,Ding Y N,et al.Synergistic antibacterial polyacrylonitrile/gelatin nanofibers coated with metal-organic frameworks for accelerating wound repair[J].Int J Biol Macromol,2021,189:698-704.
[22] Yu M Z,Zhang G K,Li P L,et al.Acid-activated ROS generator with folic acid targeting for bacterial biofilm elimination[J].Mater Sci Eng C-Mater Biol Appl,2021,127:112225.
[23] Zhang Y M,Zhang X,Song J,et al.Ag/H-ZIF-8 nanocompo-site as an effective antibacterial agent against pathogenic bacteria[J].Nanomaterials,2019,9(11):1579.
[24] Rahmati Z,Abdi J,Vossoughi M,et al.Ag-doped magnetic metal organic framework as a novel nanostructured material for highly efficient antibacterial activity[J].Environ Res,2020,188:109555.
[25] Wu H,Tian H,Li J Q,et al.Self-detoxifying hollow zinc silica nanospheres with tunable Ag ion release-recapture capability:a nanoantibiotic for efficient MRSA inhibition[J].Compos Part B-Eng,2020,202:108415.
[26] Abdi J.Cu-zeolitic imidazolate framework-8 loaded on magnetic nanofiber as a high-efficient antimicrobial scaffold[J].J nanostruct,2020,10(4):817.
[27] Ahmad N,Nordin N A H M,Jaafar J,et al.Significant improvement in antibacterial property of ZIF-8 decorated graphene oxide by post-synthetic modification process[J].J Environ Chem Eng,2021,9(5):105887.
[28] Makhetha T A,Ray S C,Moutloali R M.Zeolitic imidazolate framework-8-encapsulated nanoparticle of Ag/Cu composites supported on graphene oxide:synthesis and antibacterial activity[J].ACS Omega,2020,5(17):9626-9640.
[29] Li X,Qi M L,Li C Y,et al.Novel nanoparticles of cerium-doped zeolitic imidazolate frameworks with dual benefits of antibacterial and anti-inflammatory functions against periodontitis[J].J Mater Chem B,2019,7(44):6955-6971.
[30] Wan Y,Fang J,Wang Y,et al.Antibacterial zeolite imidazole frameworks with manganese doping for immunomodulation to accelerate infected wound healing[J].Adv Healthc Mater,2021,10(22):e2101515.
[31] Zhang W,Zhou Y N,Fan Y T,et al.Metal-organic-framework-based hydrogen-release platform for multieffective helicobacter pylori targeting therapy and intestinal flora protective capabilities[J].Adv Mater,2022,34(2):2105738.
[32] Redfern J,Geerts L,Seo J W,et al.Toxicity and antimicrobial properties of ZnO@ZIF-8 embedded silicone against planktonic and biofilm catheter-associated pathogens[J].ACS Appl Nano Mater,2018,1(4):1657-1665.
[33] Hui S H,Liu Q Q,Huang Z Z,et al.Gold nanoclusters-decorated zeolitic imidazolate frameworks with reactive oxygen species generation for photoenhanced antibacterial study[J].Bioconjug Chem,2020,31(10):2439-2445.
[34] Li J,Gopal A,Karaosmanoglu S,et al.Photosensitizer doped zeolitic imidazolate framework-8 nanocomposites for combined antibacterial therapy to overcome methicillin-resistant staphylococcus aureus (MRSA)[J].Colloids Surf B Biointerfaces,2020,190:110900.
[35] Duan S H,Zhao X,Su Z H,et al.Layer-by-layer decorated nanoscale ZIF-8 with high curcumin loading effectively inactivates gram-negative and gram-positive bacteria[J].ACS Appl Bio Mater,2020,3(6):3673-3680.
[36] Wang M J,Nian L Y,Cheng Y L,et al.Encapsulation of colloidal semiconductor quantum dots into metal-organic frameworks for enhanced antibacterial activity through interfacial electron transfer[J].Chem Eng J,2021,426:130832.
[37] Chen H,Yang J,Sun L,et al.Synergistic chemotherapy and photodynamic therapy of endophthalmitis mediated by zeolitic imidazolate framework-based drug delivery systems[J].Small,2019,15(47):1903880.
[38] Song Z Y,Wu Y,Cao Q,et al.pH-responsive,light-triggered on-demand antibiotic release from functional metal-organic framework for bacterial infection combination therapy[J].Adv Funct Mater,2018,28(23):180001.
[39] Wen T,Lin Z Y,Zhao Y T,et al.Bioresponsive nanoarchitectonics-integrated microneedles for amplified chemo-photodynamic therapy against acne vulgaris[J].ACS Appl Mater Interfaces,2021,13(41):48433-48448.
[40] Deng Z W,Li M H,Hu Y,et al.Injectable biomimetic hydrogels encapsulating gold/metal-organic frameworks nanocomposites for enhanced antibacterial and wound healing activity under visible light actuation[J].Chem Eng J,2021,420(1):129668.
[41] Teng W S Y,Zhang Z J,Wang Y K,et al.Iodine immobilized metal-organic framework for NIR-triggered antibacterial therapy on orthopedic implants[J].Small,2021,17(35):2102315.
[42] Liu H L,Zhu X L,Guo H M,et al.Nitric oxide released injec-table hydrogel combined with synergistic photothermal therapy for antibacterial and accelerated wound healing[J].Appl Mater Today,2020,20:100781.
[43] Zhang S Q,Ye J W,Liu X,et al.Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun membrane for near-infrared regulated photothermal/photodynamic therapy of drug-resistant bacterial infections[J].J Colloid Interface Sci,2021,599:390-403.
[44] Wang Z F,Peng Y L,Zhou Y,et al.Pd-Cu nanoalloy for dual stimuli-responsive chemo-photothermal therapy against pathogenic biofilm bacteria[J].Acta Biomater,2022,137:276-289.
[45] Liu Z W,Tan L,Liu X M,et al.Zn2+-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs[J].Colloids Surf B Biointerfaces,2020,188:110781.
[46] Hui S H,Liu Q Q,Han Y D,et al.ICG@ZIF-8/PDA/Ag composites as chemo-photothermal antibacterial agents for efficient sterilization and enhanced wound disinfection[J].J Mater Chem B,2021,9(48):9961-9970.
[47] Yang Y Y,Guo Z P,Huang W,et al.Fabrication of multifunctional textiles with durable antibacterial property and efficient oil-water separation via in situ growth of zeolitic imidazolate framework-8 (ZIF-8) on cotton fabric[J].Appl Surf Sci,2020,503:144079.
[48] Shiu B C,Zhang Y,Yuan Q Y,et al.Preparation of Ag@ZIF-8@PP melt-blown nonwoven fabrics:air filter efficacy and antibacterial effect[J].Polymers,2021,13(21):3773.
[49] Mu C L,Ren J H,Chen H,et al.Graphitic carbon nitride/zeolitic imidazolate framework-8 nanoparticles with antibacterial properties for textile coating[J].ACS Appl Nano Mater,2021,4(10):10634-10644.
[50] Zheng X H,Zhang Y,Zou L H,et al.Robust ZIF-8/alginate fibers for the durable and highly effective antibacterial textiles[J].Colloids Surf B Biointerfaces,2020,193:111127.
[51] Li T T,Zhang H,Gao B,et al.Daylight-driven rechargeable,antibacterial,filtrating micro/nanofibrous composite membranes with bead-on-string structure for medical protection[J].Chem Eng J,2021,422:130007.
[52] Kumar A,Sharma A,Chen Y,et al.Copper@ZIF-8 core-shell nanowires for reusable antimicrobial face masks[J].Adv Funct Mater,2021,31(10):2008054.
基金资助
国家自然科学基金(82201128);中国博士后科学基金(2022M722250);四川省博士后科研项目特别资助经费(TB2022045)
PDF
