构建多模式纳米药物体系是提高抗肿瘤靶向性治疗效果的有效手段之一,能够克服传统化疗单一模式的局限性,并降低对人体的毒副作用。二氧化锰(MnO2)作为过渡金属氧化物,因其性质优越已广泛应用于生物医学领域,尤其是在调节肿瘤微环境方面更显示出了独特的优势。总结了应用于抗癌领域中MnO2纳米材料的制备方法;阐述了MnO2纳米材料在肿瘤微环境调节以及药物递送系统中的应用;最后,展望了MnO2纳米材料在构建抗肿瘤药物体系及其在抗癌应用中的发展方向以及面临的挑战。
The construction of multi-modal nanodrug systems is one of the effective approaches to improve the effectiveness of anti-tumor targeted therapy,which can overcome the limitations of the traditional single mode of chemotherapy and reduce the toxic side effects on the human body.As a transition metal oxide,manganese dioxide (MnO2) has been widely used in the biomedical field because of its special properties,especially in regulating the tumor microenvironment.This paper summarized the preparation methods of MnO2 nanomaterials applied in anti-tumor field,and elaborated the applications of MnO2 nanomaterials in tumor microenvironment regulation and drug delivery systems.Finally,we looked forward to the development directions and challenges of MnO2 nanomaterials in the construction of anti-tumor drug systems and their anti-cancer applications.
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基金资助
国家自然科学基金(21562014);贵州中烟工业有限公司项目(GZZY/KJ/JS/2014＿Y005-1)
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