以外消旋乳酸(D, L-LA)和聚乙二醇(PEG)为原料, 合成了不同比例的聚乳酸-聚乙二醇共聚物(PLEG), 通过红外光谱和核磁共振测试了所得共聚物的结构。以PLEG为软段, 二苯基甲烷二异氰酸酯(MDI)与 1, 4-丁二醇(BDO)为硬段制备了聚氨酯膜材料(PPU)。通过红外光谱、扫描电镜、热重测试、力学测试和接触角测试等手段分析了PPU结构中PLA链段含量对其结构和性能的影响。在磷酸盐缓冲液中对PPU的可降解性进行测试, 同时考察了其生物相容性。结果表明:随着PLA链段比例的升高, PPU的透明性、热分解温度、力学强度、韧性、亲水性均有所下降, 而降解性能显著增强。此外, PPU膜具有优异的生物相容性, 将在生物医用和化工环保等领域具有广阔的医用前景。
Polylactic acid-polyethylene glycol copolymers (PLEG) with different proportions were synthesized from racemic lactic acid (D, L-LA) and polyethylene glycol (PEG).The structures of the obtained copolymers were characterized by Fourier transform infrared spectrometry (FT-IR) and nuclear magnetic resonance (NMR).Then, PLEG was used as the soft segment and diphenylmethane diisocyanate (MDI) and 1, 4-butanediol (BDO) were used as the hard segment for the preparation of polyurethane membranes.The effects of the content of the PLA chain segments on the structure and properties of PPU were analyzed by FT-IR, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), mechanical property test and contact angle test.Subsequently, the degradability of PPU membranes was tested in phosphate buffer solution (PBS), and the biocompatibility was evaluated as well.The results showed that with the increase of the proportion of PLA chain segments, the transparency, thermal decomposition temperature, mechanical strength, toughness and hydrophilicity of PPU decreased, while the degradation performance increased significantly.In addition, the PPU membrane exhibited excellent biocompatibility, and would have broad application prospects in the fields of biomedical, chemical and environmental protection.
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