姜黄素(Cur)在医药上有着很广泛的应用,可用于抗癌、抗菌、抗病毒、抗炎等。制备了一种聚乙烯醇/聚丙烯酸(PVA/PAA)载姜黄素纳米纤维材料,可用于伤口敷料,能有效抗菌,可促进伤口愈合。首先采用二甲亚砜将姜黄素溶解,再将含有姜黄素的溶液与PVA/PAA水溶液共混,利用静电纺丝技术制备出纳米纤维膜后对其进行高温热交联处理使其提高耐水性。对纳米纤维膜的表面形貌、化学结构、抗菌性能、溶胀性能以及透湿性能进行表征与分析。结果表明:PVA/PAA载姜黄素纳米纤维膜具有一定的抗菌效果,并且透湿性以及吸液性能良好。
Curcumin is widely used in medicine.It can be used in anticancer,antibacterial,antiviral,anti-inflammatory and so on.In this paper,a curcumin loaded PVA/PAA nanofiber material was prepared and could be used in wound dressing,which could effectively inhibit bacteria and promote wound healing.Firstly,curcumin was dissolved by dimethyl sulfoxide,and then the solution containing curcumin was blended with PVA/PAA aqueous solution.The nanofiber membrane was prepared by electrospinning technology,and then it was thermally crosslinked at high temperature to improve its water resistance.The surface morphology,chemical structure,antibacterial properties,swelling properties and moisture permeability of nanofiber membrane were characterized and analyzed.The results showed that the curcumin loaded PVA/PAA nanofiber membrane had certain antibacterial effect,and had good moisture permeability and liquid absorption performance.
[1] 赵月,何婷,李茹冰.静电纺丝技术在创伤敷料方面的研究进展[J].生物医学工程研究,2017,36(1):90-94.
[2] 杜磊.基于静电纺丝技术的双组份/双载药敷料可控制备及其性能研究[D].杭州:浙江理工大学,2017.
[3] 李卫昌.静电纺丝/静电喷雾制备生物医用材料[D].广州:华南理工大学,2017.
[4] 乔延超.负载姜黄素的聚乙烯醇缩丁醛膜的制备及其抗菌性能研究[D].吉林:长春工业大学,2020.
[5] 王静.一种细菌纤维素/姜黄素复合材料的制备及表征[J].复合材料学报,2018,35(7):1897-1902.
[6] 宋佳.纳米静电纺丝复合材料的皮肤创面修复作用和安全性评价[D].长春:吉林大学,2017.
[7] 邵倩倩,巫甜甜,胡洪涛,等.静电纺纳米纤维敷料在创伤修复中的应用研究进展[J].广州化工,2019,47(24):41-43,47.
[8] Aliabbasi Neda,Fathi Morteza,Emam-Djomeh Zahra,et al.Curcumin:a promising bioactive agent for application in food packaging systems[J].Journal of Environmental Chemical Engineering,2021,9(4):105520.
[9] 左凌楠.载紫草素静电纺丝纳米纤维膜作为伤口敷料的研究[D].石家庄:河北医科大学,2020.
[10] 隋春红,周广栋,刘畅,等.电纺制备耐水性聚乙烯醇/聚丙烯酸纳米纤维膜及其吸附性能研究[J].印染助剂,2018,35(12):14-19.
[11] 王玮,焦体峰,侯彩丽,等.静电纺丝制备PVA/PAA/GO三元复合纤维材料[J].燕山大学学报,2015,39(4):317-321,356.
[12] 强志斌,陈寅生,郭华文,等.壳聚糖膜的制备及膜性能[J].东华大学学报(自然科学版),2007,33(2):212-215,220.
[13] 张敏.聚偏氟乙烯/聚乙烯醇缩丁醛复合纳米纤维膜的制备及其防水透湿性能研究[D].上海:东华大学,2017.
[14] 殷茂力.壳聚糖基抗菌医用材料的构建与性能研究[D].无锡:江南大学,2021.
[15] Mutlu Gozde,Calamak Semih,Ulubayram Kezban,et al.Curcumin-loaded electrospun PHBV nanofibers as potential wound-dressing material(Article)[J].Journal of Drug Delivery Science and Technology,2018,43:185-193.
[16] Agarwal Y,Rajinikanth P S,Ranjan S,et al.Curcumin loaded polycaprolactone-/polyvinyl alcohol-silk fibroin based electrospun nanofibrous mat for rapid healing of diabetic wound:an in-vitro and in-vivo studies[J].International journal of biological macromolecules,2021,176:376-386.
[17] 任倩,李芳颖,黄政,等.水性聚合物纳米纤维PM2.5过滤材料开发[J].纺织导报,2018(8):45-48,50.
[18] 王春红,李明,龙碧旋,等.聚乙烯醇/海藻酸钠/黄连素医用敷料制备及其性能[J].纺织学报,2021,42(5):16-22.
[19] Tyagi P,Singh M,Kumari H,et al.Bactericidal Activity of Curcumin I Is Associated with Damaging of Bacterial Membrane[J].PloS One,2015,10(3):e0121313.
[20] Md Musavvir Mahmuda,Sumaiya Zamanb,Asma PerveenM,et al.Controlled release of curcumin from electrospun fiber mats with antibacterial activity)[J].Journal of Drug Delivery Science and Technology,2020,55:101386.
基金资助
国家自然科学基金青年基金项目(21706093)
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