化工新型材料

化工新型材料 ›› 2023, Vol. 51 ›› Issue (4) : 238-242. DOI: 10.19817/j.cnki.issn1006-3536.2023.04.042

科学研究

丹酚酸B杂化纳米花的合成与体外抗氧化活性研究

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Synthesis,characterization and in vitro antioxidant activity of salvianolic acid B hybrid nanoflower

Wang Ruixing¹, Xie Yipeng², Wang Cheli¹

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文章历史 +

Received		Published
2022-01-11		2023-04-20
Issue Date	Revised Date
2023-04-27	2022-01-11

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摘要

首次将丹参中主要有效成分丹酚酸B(SAB)制备成具有抗氧化活性的SAB@Cu₃(PO₄)₂杂化纳米花。采用扫描电镜(SEM)、傅里叶变换红外光谱仪(FT-IR)、X射线能量色散谱仪(EDS)、激光粒度分布仪等进行表征,证实了SAB@Cu₃(PO₄)₂杂化纳米花的合成并确定其形貌、结构特征。之后,对杂化纳米花的抗氧化性进行探究,发现与游离丹酚酸B相比,杂化纳米花的抗氧化活性提高了92.2%。此外,杂化纳米花的稳定性也有显著提高,其在80℃下放置12h后仍能保留80.57%的抗氧化活性。

Abstract

In this study,for the first time,salvianolic acid B (SAB),the main active ingredient in Salvia miltiorrhiza,was encapsulated into hybrid nanoflower (SAB@Cu₃(PO₄)₂) with antioxidant property.The prepared SAB@Cu₃(PO₄)₂ was characterized by scanning electron microscopy (SEM),Fourier transform infrared spectroscopy (FT-IR),X-ray energy dispersive spectroscopy (EDS),laser particle size distribution analyzer,etc.,which confirmed that SAB@Cu₃(PO₄)₂ was successfully synthesized and determined its morphology and structural property.After that,the antioxidant activity of SAB@Cu₃(PO₄)₂ was explored and it was found that the antioxidant activity of SAB@Cu₃(PO₄)₂ increased by 90% compared with free salvianolic acid B.In addition,the stability of SAB@Cu₃(PO₄)₂ was also significantly improved,and it could still retain 80.57% of the antioxidant activity after being placed at 80℃ for 12h.

关键词

杂化纳米花 / 丹酚酸B / 抗氧化性

Key words

hybrid nanoflower / salvianolic acid B / antioxidant activity

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丹酚酸B杂化纳米花的合成与体外抗氧化活性研究[J]. 化工新型材料, 2023, 51(4): 238-242 DOI:10.19817/j.cnki.issn1006-3536.2023.04.042

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