环境中的各类致病菌是危害人类健康的潜在因素,相应的快速、精准检测方法的开发具有重要意义。碳量子点作为一种具有卓越的荧光性能、良好的荧光稳定性与生物安全性、易于化学修饰和功能化等性质的新型碳纳米材料,在致病菌检测方面极具发展潜力,并且碳量子点荧光探针检测技术操作简单、检测快速、不需要大型仪器设备。近年来,碳量子点的综述主要集中在制备方法及性质等方面,鲜有碳量子点荧光探针在致病菌检测方面进展的描述。简述了碳量子点的特性,分析了3种碳量子点荧光探针在致病菌检测中的应用,提出了碳量子点与磁性纳米材料和特异性识别物质相结合,构建灵敏度高、特异性强的磁性碳量子点复合荧光探针是碳量子点在致病菌检测方面的重要发展方向。
All kinds of pathogenic microorganisms in the environment are potential causes harmful to human health.The development of corresponding rapid and accurate detection methods is of great significance.As a new type of carbon nanomaterial,carbon quantum dots(CQDs) display excellent fluorescence performance,good fluorescence stability,good biosafety,and easy to be chemically modified and functionalized.So they have great development potential in the detection of pathogenic microorganisms.Moreover,the detection technology using CQDs is simple to operate and does not require large-scale instruments and equipment.In recent years,the review of CQDs mainly focuses on the preparation methods and properties,and the research progress of CQDs fluorescent probes in the detection of pathogenic microorganisms was rarely described.The characteristics of CQDs were briefly described,and analyzed the application of three kinds of CQDs fluorescent probes in the detection of pathogenic microorganisms.The combination of CQDs with magnetic nanomaterials and specific recognition materials to construct magnetic CQDs composite fluorescent probes with high sensitivity and specificity is an important development direction of CQDs in pathogenic microorganism detection.
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基金资助
国家自然科学基金(31470787);吉林省十三五科技发展计划项目(20190902014TC)
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