科学研究

壳聚糖/透明质酸钠偶联水凝胶的制备及性能研究

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  • 昆明理工大学材料科学与工程学院,昆明650000
竹泳俊(1994-),男,硕士,主要从事生物医用材料的研究,E-mail:919662048@qq.com。

收稿日期: 2019-12-08

  修回日期: 2020-12-25

  网络出版日期: 2021-05-07

Fabrication and characterization of CS/SH coupled hydrogel

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  • School of Materials Science and Engineering,Kunming University of Science and Technology, Kunming 650000

Received date: 2019-12-08

  Revised date: 2020-12-25

  Online published: 2021-05-07

摘要

水凝胶材料与生物组织相似,已被广泛应用于生物医药、组织工程等医学领域。以壳聚糖(CS)和透明质酸钠(SH)为主要原料,利用1-乙基-(3-二甲基氨基丙基)碳二亚胺盐酸盐/N-羟基琥珀酰亚胺(EDC/NHS)活化透明质酸钠来与壳聚糖偶联制备出了化学交联的CS/SH偶联水凝胶。测试并分析偶联水凝胶微观形貌,红外光谱,细胞增殖,溶胀比,力学性能和降解速率。结果表明:制备的偶联水凝胶材料在皮肤、创伤修复、软骨、药物载体等领域具有很大前景。

本文引用格式

竹泳俊, 李艳芳, 颜廷亭, 李潘, 刘金坤, 王若璇, 冷崇燕 . 壳聚糖/透明质酸钠偶联水凝胶的制备及性能研究[J]. 化工新型材料, 2021 , 49(4) : 190 -193 . DOI: 10.19817/j.cnki.issn1006-3536.2021.04.041

Abstract

Hydrogel materials are similar to biological tissues and have been widely used in biomedical,tissue engineering and other medical fields.Chitosan(CS) and sodium hyaluronate(SH) were used as the main raw materials,and hyaluronic acid was activated by EDC/NHS.Sodium was coupled with chitosan to prepare a chemically crosslinked CS/SH coupled hydrogel.And its microstructure,infrared spectrum,cell proliferation,swelling ratio,mechanical properties and degradation rate were tested and analyzed.The experimental results shown that the CS and SH had great potential in the preparation of non-toxic crosslinked hydrogel materials.

参考文献

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