新材料与新技术

苯并异噻唑啉酮功能化的丙烯酸树脂的合成及生物活性研究

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  • 1.海南省精细化工工程技术研究中心,海口570228;
    2.海口市绿色催化与反应工程重点实验室,海口570228;
    3.海南大学理学院,海口570228;
    4.海南大学化学工程与技术学院,海口570228
王雪梅(1994-),女,硕士研究生,主要研究方向为有机合成和海洋防污剂。

收稿日期: 2019-09-19

  修回日期: 2020-10-30

  网络出版日期: 2021-01-27

基金资助

国家自然科学基金(51663009);海南省自然科学基金(20162014);海南省高等学校教育教学改革研究项目(Hnjg2016ZD-5);海南大学大学生创新创业基金资助项目(Hdcxcyxm201703)

Synthesis and bioactivity of benzoisothiazolin-3-one functionalized acrylic resin

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  • 1. Hainan Provincial Fine Chemical Engineering Research Center,Haikou 570228;
    2. Key Laboratory of Green Catalysis and Reaction Engineering of Haikou,Haikou 570228;
    3. School of Science,Hainan University,Haikou 570228;
    4. Chemical Engineering and Technology,Hainan University,Haikou 570228

Received date: 2019-09-19

  Revised date: 2020-10-30

  Online published: 2021-01-27

摘要

以苯并异噻唑啉酮(BIT)、N-甲基烯丙基胺和三光气为原料,设计合成N-烯丙基-N-甲基取代的苯并异噻唑啉-3-酮甲酰胺单体;然后与甲基丙烯酸甲脂、丙烯酸丁酯等进行共聚反应,得到BIT功能化的丙烯酸树脂共聚物。活性测试结果表明,该类树脂对藻类及菌类的生长均有明显抑制作用。抑藻性能测试发现,共聚物对球等鞭金藻的抑制作用最强,对蛋白核小球藻最弱。抑菌性能测试发现,共聚物对金黄色葡萄球菌的抑制作用最强,对副溶血性弧菌最弱。

本文引用格式

王雪梅, 董苗, 卢凌彬, 陈俊华, 杨建新 . 苯并异噻唑啉酮功能化的丙烯酸树脂的合成及生物活性研究[J]. 化工新型材料, 2021 , 49(1) : 121 -125 . DOI: 10.19817/j.cnki.issn 1006-3536.2021.01.027

Abstract

Monomer N-allyl-N-methyl substituted benzisothiazolin-3-one carboxamide was designed and synthetised with BIT,N-allylmethylamine and triphosgene as raw materials,and the monomer was combined with n-butyl acrylate and methyl methacrylate for the synthesis of BIT functionalized acrylic resin copolymer.The structures of the copolymer were identified by means of IR and 1H-NMR,and determined the bioactivities.the results of the algal inhibition shown that the resin had obvious inhibitory effect on the growth of algae and bacteria,the inhibition effect of Isochrysis galbana was the strongest,and Chlorella pyrenoidosa was the weakest.As to antibacterial activities test,the copolymer had the strongest inhibitory effect on Staphylococcus aureus,the Vibrio Parahemolyticus was the weakest.

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