开发与应用

聚天冬氨酸苄酯改性纳米羟基磷灰石的制备

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  • 1.南昌大学科学技术学院生物化学系,南昌330029;
    2.南昌大学,南昌330031
徐敏(1986-),女,博士,讲师,主要从事无机纳米粒子改性研究,E-mail:cbxumin@yeah.net。

网络出版日期: 2020-10-20

基金资助

江西省教育厅科学技术研究项目(GJJ161522)和(GJJ191564),南昌大学科学技术学院科研基金(2013-ZR-06)

Preparation of nano-HA modified by PBLA

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  • 1.Department of Biochemistry,Nanchang University College of Science and Technology, Nanchang 330029;
    2.Nanchang University,Nanchang 330031

Online published: 2020-10-20

摘要

描述了一种羟基磷灰石(HA)表面改性的制备方法,它是通过L-天冬氨酸-β-苄酯-N-羧酸酐开环聚合的方法制得。首先,将HA和硅烷偶联剂KH-550反应得到表面含有活性氨基的改性羟基磷灰石(HAAPS)。其次,HAAPS引发L-天冬氨酸-β-苄酯-N-羧酸酐(BLA-NCA)开环聚合得到表面接枝聚天冬氨酸苄酯(PBLA)的羟基磷灰石(PBLA-g-HA),实现了HA表面由亲水性向疏水性的转变,合成结果通过红外光谱(FT-IR)与热重(TG)表征。FT-IR和TG结果均证实HA被成功接枝,通过控制不同的反应时间和比例,羟基磷灰石表面的PBLA接枝量为28.32%~60.48%。分散性实验证实经过PBLA表面改性的HA可显著地增加HA表面的疏水性和防止纳米粒子HA的聚集。

本文引用格式

徐敏, 熊兵, 舒扬, 郭建业, 帅文苑, 黄萍 . 聚天冬氨酸苄酯改性纳米羟基磷灰石的制备[J]. 化工新型材料, 2020 , 48(10) : 282 -285 . DOI: 10.19817/j.cnki.issn 1006-3536.2020.10.060

Abstract

A preparation method of hydroxyapatite(HA)surface modification was described,PBLA-g-HA was prepared by ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride.First,HA was reacted with silane coupling agent KH550 to obtain modified hydroxyapatite (HAAPS) with active amino groups on its surface.Secondly,HAAPS initiated the ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride (BLA-NCA) to obtain hydroxyapatite(PBLA-g-HA) grafted with polyaspartic acid benzyl ester (PBLA).The surface of HA was changed from hydrophilic to hydrophobic.The results were characterized by FT-IR,TGA.FT-IR and TGA showed that HA was successfully grafted.By controlling the reaction time and ratio,the grafting amount of PBLA on the surface of HA was 28.32%~60.48%.The dispersity experiment confirmed that HA modified by PBLA could significantly increase the hydrophobicity of HA surface,and prevented the aggregation of HA nanoparticles.

参考文献

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