综述与专论

半导体量子点的研究进展

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  • 1.天津工业大学化学与化工学院,天津 300387;
    2.天津工业大学中空纤维膜材料与膜过程国家重点实验室,天津 300387
毕明刚(1993-),男,硕士,主要研究方向为掺杂型荧光CdTe量子点的制备与金属离子的检测,以及合金型银纳米簇的制备与生物应用。

网络出版日期: 2020-12-07

基金资助

国家自然科学基金(21106101);天津市自然基金(12JCZDJC29500)

Progress on semiconductor quantum dot

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  • 1.School of Chemistry and Chemical Engineering,Tianjin Polytechnic University, Tianjin 300387;
    2.State Key Laboratory of Hollow Fiber Membrane Materials and Process, Tianjin Polytechnic University,Tianjin 300387

Online published: 2020-12-07

摘要

综述了量子点的合成方法,包括技术新颖的电化学合成法、应用广泛的有机相合成法和简便科学的水相合成法,介绍了常见的量子点的荧光特性、细胞毒性、表面修饰和稳定性等内容。指出了其存在荧光寿命低和易于团聚等缺点,简述了其在癌症检测和药物投递、细胞成像、离子检测,以及半乳糖氧化酶活性检测等方面的应用。最后指出,深入探究量子点表面与药物小分子结合的作用原理,降低量子点对肿瘤细胞周围组织的毒副作用,推动磁性荧光量子点和酶-纳米材料复合体系的发展,实现量子产率高、分散性好、成本低廉的荧光量子点的制备是未来研究的热门方向。

本文引用格式

毕明刚, 张纪梅 . 半导体量子点的研究进展[J]. 化工新型材料, 2020 , 48(11) : 24 -29 . DOI: 10.19817/j.cnki.issn 1006-3536.2020.11.006

Abstract

Quantum dots are a rising star among nanomaterials in recent years.They not only have fascinating properties such as luminescence effect,quantum size effect and interface effect,but also have strong chemical stability,rich surface ion species and wide ligand selectivity.Because of these advantages,so it occupies an important position in the research of luminescent materials.The synthesis methods of quantum dots including novel electrochemical synthesis methods,widely used organic phase synthesis methods,and simple and scientific aqueous phase synthesis methods were reviewed.The fluorescence characteristics,cytotoxicity,surface modification,stability and other content of common quantum dots were introduced.It pointed out its shortcomings such as low fluorescence lifetime and easy agglomeration,and briefly described its applications in cancer detection and drug delivery,cell imaging,ion detection,and galactose oxidase activity detection.Finally,it was pointed out that the principle of the combination of quantum dot surface and drug small molecule was deeply explored,the toxic side effects of quantum dots on the surrounding tissues of tumor cells were reduced,and the development of magnetic fluorescent quantum dots and enzyme-nanomaterial composite systems was promoted to achieve high quantum yield.The preparation of fluorescent quantum dots with good dispersion and low cost was a hot research direction in the future.

参考文献

[1] Bhattacharjee A,Ahmaruzzaman M.A novel and green process for the production of tin oxide quantum dots and its application as a photocatalyst for the degradation of dyes from aqueous phase[J].Journal of Colloid & Interface Science,2015,448(14):130-139.
[2] 于清跃,于荟.CdS量子点/染料共敏化TiO2纳米结构的光电化学性能研究[J].化工新型材料,2015,43(7):140-142.
[3] Tawfik S M,Huy B T,Sharipov M,et al.Enhanced fluorescence of CdTe quantum dots capped with a novel nonionic alginate for selective optosensing of ibuprofen[J].Sensors & Actuators B Chemical,2017,256:243-250.
[4] 丁玲,刘鹏,钟婷,等.量子点的制备及其在生物医学中的应用进展[J].化工进展,2010,29(9):1681-1686.
[5] Verma N.A green synthetic approach for size tunable nanoporous gold nanoparticles and its glucose sensing application[J].Applied Surface Science,2018,462:753-759.
[6] Velusamy V,Palanisamy S,Kokulnathan T,et al.Novel electrochemical synthesis of copper oxide nanoparticles decorated graphene-beta-cyclodextrin composite for trace-level detection of antibiotic drug metronidazole[J].Journal of Colloid and Interface Science,2018,530:37-45.
[7] Deng X Y,Feng Y L,Li H R,et al.N-doped carbon quantum dots as fluorescent probes for highly selective and sensitive detection of Fe3+ ions[J].Particuology,2018,41:94-100.
[8] Kim E M,Lim S T,Sohn M H,et al.Facile synthesis of near-infrared CuInS2/ZnS quantum dots and glycol-chitosan coating for in vivo imaging[J].Journal of Nanoparticle Research,2017,19(7):251.
[9] Cui Q,Xu J,Shen G,et al.Hybridizing carbon nitride colloids with a shell of water-soluble conjugated polymers for tunable full-color emission and synergistic cell imaging[J].ACS Applied Materials & Interfaces,2017,9(50):43966-43974.
[10] Manna S,Bhattacharya S,Sengupta S,et al.Synthesis of graphene oxide dots coated biomatrices and its application for the removal of multiple pollutants present in wastewater[J].Journal of Cleaner Production,2018,203:83-88.
[11] Wang H L,Zhu W J,Fang M,et al.Turn-on fluorescence probe for high sensitive and selective detection of Ag+ by L-glutathione capped CdTe quantum dots in aqueous medium[J].Journal of Luminescence,2016,180:14-19.
[12] Ncapayi V,Parani S,Songca S P,et al.Green synthesis of MPA-capped CdTe/CdSe quantum dots at different pH and its effect on the cell viability of fibroblast histiocytoma cells[J].Materials Letters,2017,209:299-302.
[13] Ye L,Yong K T,Liu L W,et al.A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots[J].Nature Nanotechnology,2012,7(7):453-458.
[14] Zu H R,Guo Y X,Yang H Y,et al.Rapid room-temperature preparation of MoO3-x quantum dots by ultraviolet irradiation for photothermal treatment and glucose detection[J].New Journal of Chemistry,2018,42(23):18533-18540.
[15] Guo T,Sampat S,Rupich S M,et al.Biexciton and trion energy transfer from CdSe/CdS giant nanocrystals to Si substrates[J].Nanoscale,2017,9(48):19398-19407.
[16] Khan H,Zavabeti A,Wang Y,et al.Quasi physisorptive two dimensional tungsten oxide nanosheets with extraordinary sensitivity and selectivity to NO2[J].Nanoscale,2017,9(48):19162-19175.
[17] Cao M,Yu C,Xia J,et al.Full-visible spectrum emitting Zn-In-S:Cu/ZnS nanocrystals based on varying Cu concentrations and its application in white LEDs[J].Journal of the American Ceramic Society,2018,101(12):5586-5595.
[18] Liu G,Lu M,Huang X,et al.Application of gold-nanoparticle colorimetric sensing to rapid food safety screening[J].Sensors,2018,18(12):4166.
[19] Park Y,Park B.Effect of ligand exchange on photocurrent enhancement in cadmium selenide (CdSe) quantum dot water splitting cells[J].Results in Physics,2018,11:162-165.
[20] Habimana J D D,Ji J,Pi F W,et al.A class-specific artificial receptor-based on molecularly imprinted polymer-coated quantum dot centers for the detection of signaling molecules,N-acyl-homoserine lactones present in gram-negative bacteria[J].Analytica Chimica Acta,2018,1031:134-144.
[21] Anas A,Okuda T,Kawashima N,et al.Clathrin-mediated endocytosis of quantum dot-peptide conjugates in living cells[J].ACS Nano,2009,3(8):2419-2429.
[22] Cunha C R A,Andrade C G,Pereira M I A,et al.Quantum dot-Cramoll lectin as novel conjugates to glycobiology[J].Journal of Photochemistry and Photobiology B-Biology,2018,178:85-91.
[23] Bisquert J.Beyond the quasistatic approximation:impedance and capacitance of an exponential distribution of traps[J].Physical Review B,2008,77(23):235203.
[24] Tulsani S R,Rath A K.Photo-induced surface modification to improve the performance of lead sulfide quantum dot solar[J].Journal of Colloid and Interface Science,2018,522:120-125.
[25] Mansur A A P,Mansur H S,Ramanery F P,et al.“Green” colloidal ZnS quantum dots/chitosan nano-photocatalysts for advanced oxidation processes:study of the photodegradation of organic dye pollutants[J].Applied Catalysis B Environmental,2014,158:269-279.
[26] Bardajee G R,Bayat M,Nasri S,et al.Ph-responsive fluorescent dye-labeled metal-chelating polymer with embedded cadmium telluride quantum dots for controlled drug release of doxorubicin[J].Reactive & Functional Polymers,2018,133:45-56.
[27] Brazhnik K,Sokolova Z,Baryshnikova M,et al.Quantum dot-based lab-on-a-bead system for multiplexed detection of free and total prostate-specific antigens in clinical human serum samples[J].Nanomedicine Nanotechnology Biology & Medicine,2015,11(5):1065-1075.
[28] Feng T,Ai X,An G,et al.Charge-convertible carbon dots for imaging-guided drug delivery with enhanced in vivo cancer therapeutic efficiency[J].ACS Nano,2016,10(4):4410-4420.
[29] Delehanty J B,Bradburne C E,Susumu K,et al.Spatiotemporal multicolor labeling of individual cells using peptide-functionalized quantum dots and mixed delivery techniques[J].Journal of the American Chemical Society,2011,133(27):10482-10489.
[30] Li J,Wang H,Dong S,et al.Quantum-dot-tagged photonic crystal beads for multiplex detection of tumor markers[J].Chemical Communications,2014,50(93):14589-14592.
[31] Wang C,Hou F,Ma Y.Simultaneous quantitative detection of multiple tumor markers with a rapid and sensitive multicolor quantum dots based immunochromatographic test strip[J].Biosensors & Bioelectronics,2015,68:156-162.
[32] Kostarelos K,Bianco A,Prato M.Promises,facts and challenges for carbon nanotubes in imaging and therapeutics[J].Nature Nanotechnology,2009,4(10):627-633.
[33] 刘欢,张洪文,汤玉英,等.绿色荧光碳量子点的细胞成像研究[J].化工新型材料,2019,47(2):264-267.
[34] Resch-Genger U,Grabolle M,Cavaliere-Jaricot S,et al.Quantum dots versus organic dyes as fluorescent labels[J].Nature Methods,2008,5(9):763-775.
[35] 程志飞,吴迪,刘品祯等.量子点在分析检测中的应用研究[J].化工新型材料,2018,46(3):269-272.
[36] Kumari A,Singh R R.Encapsulation of highly confined CdSe quantum dots for defect free luminescence and improved stability[J].Physica E-Low-Dimensional Systems & Nanostructures,2017,89:77-85.
[37] Jandi K,Bui The H,Sakthivel K,et al.Highly fluorescent CdTe quantum dots with reduced cytotoxicity-a robust biomarker[J].Sensing and Bio-Sensing Research,2015,3:46-52.
[38] Kumari A,Sharma A,Malairaman U,et al.Proficient surface modification of CdSe quantum dots for highly luminescent and biocompatible probes for bioimaging:a comparative experimental investigation[J].Journal of Luminescence,2018,199:174-182.
[39] Bharali D J,Lucey D W,Jayakumar H,et al.Folate-receptor-mediated delivery of inp quantum dots for bioimaging using confocal and two-photon microscopy[J].Journal of the American Chemical Society,2005,127(32):11364-11371.
[40] Meng H,Chen J Y,Mi L,et al.Conjugates of folic acids with BSA-coated quantum dots for cancer cell targeting and imaging by single-photon and two-photon excitation[J].Jbic Journal of Biological Inorganic Chemistry,2011,16(1):117-123.
[41] Sun L,Zang Y,Sun M,et al.Synthesis of magnetic and fluorescent multifunctional hollow silica nanocomposites for live cell imaging[J].Journal of Colloid & Interface Science,2010,350(1):90-98.
[42] Baytak S,Kasumov V T.Preconcentration and determination of copper(ii) by novel solid-phase extraction and high-resolution continuum source flame atomic absorption spectrometry[J].Analytical Letters,2017,50(1):105-116.
[43] Arslan Z,Oymak T,White J.Triethylamine-assisted Mg(OH)2 coprecipitation/preconcentration for determination of trace metals and rare earth elements in seawater by inductively coupled plasma mass spectrometry (ICP-MS)[J].Analytica Chimica Acta,2018,1008:18-28.
[44] Xu W,Zhu L,Shao X,et al.An electrochemical biosensor based on nucleic acids enzyme and nanochannels for detecting copper(ⅱ) ion[J].Biosensors & Bioelectronics,2018,120:168-174.
[45] Zhang Y,Ren T,Tian H,et al.Hydrogel-encapsulated enzyme facilitates colorimetric acute toxicity assessment of heavy metal ions[J].ACS Applied Materials & Interfaces,2018,10(31):26705-26712.
[46] Guo J,Huang H,Zhou M,et al.Quantum dots-doped tapered hydrogel waveguide for ratiometric sensing of metal ions[J].Analytical Chemistry,2018,90(20):12292-12298.
[47] Ying R,Lu H,Xu S.Ion imprinted dual reference ratiometric fluorescence probe for respective and simultaneous detection of Fe3+ and Cu2+[J].New Journal of Chemistry,2019,43(16):6404-6410.
[48] Cui X,Zhu L,Wu J,et al.A fluorescent biosensor based on carbon dots-labeled oligodeoxyribonucleotide and graphene oxide for mercury(ⅱ) detection[J].Biosensors & Bioelectronics,2015,63:506-512.
[49] Mahmoud W E.Functionalized me-capped CdSe quantum dots based luminescence probe for detection of Ba2+ ions[J].Sensors & Actuators B Chemical,2012,164(1):76-81.
[50] Chen C Y,Cheng C T,Lai C W,et al.Potassium ion recognition by 15-crown-5 functionalized CdSe/ZnS quantum dots in H2O[J].Chemical Communications,2006,3(3):263-265.
[51] Prasuhn D E,Feltz A,Blancocanosa J B,et al.Quantum dot peptide biosensors for monitoring caspase 3 proteolysis and calcium ions[J].ACS Nano,2011,4(9):5487-5497.
[52] Adegoke O,Park E Y.Size-confined fixed-composition and composition-dependent engineered band gap alloying induces different internal structures in L-cysteine-capped alloyed quaternary cdzntes quantum dots[J].Scientific Reports,2016,6:27288.
[53] Mao G,Liu C,Du M,et al.One-pot synthesis of the stable CdZnTeS quantum dots for the rapid and sensitive detection of copper-activated enzyme[J].Talanta,2018,185:123-131.
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