软骨组织修复一直是组织工程(TE)中的研究热点。选用医用级聚己内酯(m-PCL)通过熔体静电纺丝直写技术制备PCL骨-软骨复合支架,其纤维平均直径为20.4～36.2μm,10层纤维拉伸强度为3.44M～5.75MPa,抗压强度为0.032MPa,孔隙率为90.4%。实验结果表明,熔体静电纺丝直写技术制备的m-PCL骨-软骨复合支架具有良好的机械强度、高孔隙率和微米级纤维直径,并且可以通过网格孔径和纤维膜层数的调控及不同支架材料的选取,可应用于骨-软骨的各个分层结构,在TE和医学领域中具有广阔的应用前景。
Cartilage tissue repair has always been a research hotspot in tissue engineering (TE).The medical grade polycaprolactone (m-PCL) was prepared by melt electrospinning direct writing technology.A bone-cartilage composite scaffold with a porosity of 90.4% was prepared,the average fiber diameter was 20.4～36.2μm,the 10-layer fiber tensile strength was 3.44～5.75MPa,and the compressive strength was 0.032MPa.The results shown that the m-PCL scaffold prepared by melt electrospinning direct writing technology had good mechanical strength,high porosity and micron fiber diameter,and can be adjusted by mesh pore size and fiber membrane layer.And the selection of different scaffold materials can be applied to each layered structure of bone-cartilage,and had broad application prospects in TE and its medical field.
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