一种新型的Cu-LBMS@SiO<sub>2</sub>纳米复合材料的合成及缓释性能研究

王辉, 杨海峰

doi:10.19817/j.cnki.issn 1006-3536.2020.08.018

化工新型材料 >

2020 , Vol. 48 >Issue 8: 85 - 90

DOI: https://doi.org/10.19817/j.cnki.issn 1006-3536.2020.08.018

新材料与新技术

一种新型的Cu-LBMS@SiO₂纳米复合材料的合成及缓释性能研究

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1.宝鸡文理学院化学化工学院,陕西省植物化学重点实验室,宝鸡721013;
2.宝鸡文理学院物理与光电技术学院,医用微纳材料研究中心,宝鸡721016

王辉(1982-),女,硕士,讲师,主要从事缓释药物材料方面的研究。

收稿日期: 2020-01-16

修回日期: 2020-05-27

网络出版日期: 2020-10-23

基金资助

国家自然科学基金(51702006);陕西省工业科技攻关项目(2016GY-226);宝鸡市科技厅项目(2018JH-03)

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Synthesis and sustained release of a novel Cu-LBMS@SiO₂ nanocomposite microsphere

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1. College of Chemistry and Chemical Engineering,Shaanxi Key Laboratory of Phytochemistry,Baoji University of Arts and Sciences,Baoji 721013;
2. College of Physics and Optoelectronics Technology,Medical Micro-nano Materials Research Center,Baoji University of Arts and Sciences,Baoji 721016

Received date: 2020-01-16

Revised date: 2020-05-27

Online published: 2020-10-23

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摘要

水滑石类层状化合物因具有易于聚集特点,使其在医药等方面的应用受到限制。利用水热合成法,将层状氢氧化苯甲酸铜(Cu-LBMS)不加任何交联剂直接沉积到SiO₂微球上,制备了一种新型核壳结构的纳米复合材料Cu-LBMS@SiO₂,并将其用于缓释给药系统。制备的纳米复合微球通过扫描电镜(SEM)、X射线衍射(XRD)和红外光谱(FT-IR)等方法进行表征和分析,SEM结果表明该复合微球的形貌为疏松多孔的球形,XRD和FT-IR进一步证明了该纳米复合材料的形成。最后以槲皮素为模型药物,探讨了该纳米复合微球对槲皮素的载药性能及体外的释药性。结果表明:Cu-LBMS@SiO₂纳米复合微球对槲皮素的载药量比Cu-LBMS高31.49mg/g,其体外释药主要集中在5～7h,在7h的累积释药量达到91.56%,其缓释效果明显优于Cu-LBMS和其物理混合物。

关键词： 层状氢氧化苯甲酸铜; Cu-LBMS@SiO₂; 槲皮素; 载药性能; 缓释性能

本文引用格式

王辉, 杨海峰 . 一种新型的Cu-LBMS@SiO₂纳米复合材料的合成及缓释性能研究[J]. 化工新型材料, 2020 , 48(8) : 85 -90 . DOI: 10.19817/j.cnki.issn 1006-3536.2020.08.018

Abstract

Layered compounds with a brucite-like structure has the characteristic of easy aggregation which would hamper their practical application in pharmaceuticals industry.A novel layered hydroxide cupric benzoate@SiO₂(Cu-LBMS@SiO₂) nanocomposite microspheres with core-shell structure were prepared by directly depositing the layered hydroxide cupric benzoate(Cu-LBMS) on the surface of silica spheres without any blinder.The obtained nanocomposite microspheres Cu-LBMS@SiO₂ were characterized by SEM,XRD and FT-IR.The morphology of Cu-LBMS@SiO₂ observed by SEM was soft porous spheres,XRD patterns and FT-IR spectra provided consistent evidence to the formation of Cu-LBMS@SiO₂ nano-microspheres.The controlled release behavior and drug loading capability of Cu-LBMS@SiO₂ were also investigated by using quercetin as the model drug.The results indicated that the drug loading capability of Cu-LBMS@SiO₂ was 31.49mg/g higher than Cu-LBMS.The drug release was mainly concentrated at 5～7h,and approximately 7h was needed for Cu-LBMS@SiO₂ to release 91.56% of entrapped quercetin.The sustained release behavior obviously improved than Cu-LBMS and the physical mixture.

Key words： layered hydroxide cupric benzoate(Cu-LBMS); Cu-LBMS@SiO₂; quercetin; drug loading capacity; sustained release

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