综述与专论

急救用新型快速止血材料研究进展

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  • 北京理工大学材料学院,北京100081
杨珏莹(1996-),女,博士,研究方向为天然高分子材料。

收稿日期: 2019-04-23

  网络出版日期: 2022-11-01

基金资助

中央高校基本科研业务费专项基金资助;国家大学生创新项目资助(201710007061)

Research progress on the new-type quick hemostatic material for first aid

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  • School of Materials Science &Engineering,Beijing Institute of Technology,Beijing 100081

Received date: 2019-04-23

  Online published: 2022-11-01

摘要

快速止血对于战伤性大出血、临床手术不可控出血、创伤导致动脉破损等意外事故出血具有重要意义。在对止血材料进行分类的基础上,针对其应用特点总结了新型快速止血材料的性能要求,综述了无机材料、天然高分子材料和合成高分子材料等新型止血材料的研究及应用现状,对其发展前景进行了展望。

本文引用格式

杨珏莹, 林礼智, 陈煜, 魏爱玲, 张莹, 晏直誉, 唐术衔 . 急救用新型快速止血材料研究进展[J]. 化工新型材料, 2020 , 48(7) : 24 -29 . DOI: 10.19817/j.cnki.issn 1006-3536.2020.07.006

Abstract

Effective hemostasis is significant for accidental bleeding,especially for war wounds,uncontrolled bleeding from clinical procedures and traumatic bleeding caused by trauma.The research and application of hemostatic materials were classified.Based on their application characteristics,the main requirements for the new-type quick hemostatic materials were proposed.Then the research progress of the materials,including inorganic materials,natural polymer materials and synthetic polymer materials,were reviewed.Finally,the development and application of effective hemostats in future was prospected.

参考文献

[1] Hamada S R,Rosa A,Gauss T,et al.Development and validation of a pre-hospital “Red Flag” alert for activation of intra-hospital haemorrhage control response in blunt trauma[J].Critical Care,2018,22(1):113.
[2] Hsu B B,Hagerman S R,Jamieson K,et al.Multifunctional self-assembled films for rapid hemostat and sustained anti-infective delivery[J].ACS Biomaterials Science & Engineering,2015,1(3):148-156.
[3] Kudela D,Smith S A,May-Masnou A,et al.Clotting activity of polyphosphate-functionalized silica nanoparticles[J].Angewandte Chemie International Edition,2015,54(13):4018-4022.
[4] 何海燕,张连阳.战伤急救技术研究进展[J].解放军医药杂志,2012,5(24):1-3.
[5] 廖伟雄,冯聪,滕玥,等.战伤性大出血止血技术研究进展[J].临床急诊杂志,2017,18(9):641-645.
[6] Behrens A M,Sikorski M J,Li T,et al.Blood-aggregating hydrogel particles for use as a hemostatic agent[J].Acta Biomaterialia,2014,10(2):701-708.
[7] 吕世佼,陈淑花,王景昌,等.壳聚糖基膜的制备及其生物医药应用研究[J].化工新型材料,2017,45(7):241-243.
[8] Huang X F,Sun Y F,Nie J Y,et al.Using absorbable chitosan hemostatic sponges as a promising surgical dressing[J].International Journal of Biological Macromolecules,2015,75:322-329.
[9] Chen Y,Zhang Y,Wang F,et al.Preparation of porous carboxymethyl chitosan grafted poly (acrylic acid) superabsorbent by solvent precipitation and its application as a hemostatic wound dressing[J].Materials Science and Engineering:C,2016,63:18-29.
[10] Aderibigbe B,Buyana B.Alginate in wound dressings[J].Pharmaceutics,2018,10(2):42.
[11] 余雪松,黄赤兵,张艮甫.局部止血材料临床应用现状[J].创伤外科杂志,2008(6):565-567.
[12] Chan L W,Wang X,Wei H,et al.A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis[J].Science Translational Medicine,2015,7(277):229-277.
[13] Bayat N,Zhang Y,Falabella P,et al.A reversible thermoresponsive sealant for temporary closure of ocular trauma[J].Science Translational Medicine,2017,9(419):3879.
[14] 许原,李济祥,刘瑞来.壳聚糖微球制备及止血研究进展[J].化工新型材料,2016,44(10):236-238.
[15] Ward K R,Tiba M H,Holbert W H,et al.Comparison of a new hemostatic agent to current combat hemostatic agents in a swine model of lethal extremity arterial hemorrhage[J].The Journal of Trauma Injury Infection and Critical Care,2007,63(2):276-283.
[16] Wang Y,Ni H.Fibronectin maintains the balance between hemostasis and thrombosis[J].Cellular and Molecular Life Sciences,2016,73(17):3265-3277.
[17] Tacconelli E M N.Global priority list of antibiotic-resistant bacteria to guide research,discovery,and development of new antibiotics[EB/OL][2017-02-27].http://www.who.int/medicines/publications/global-priority-list-antibiotic-resistant-bacteria/en.
[18] Murray C K,Hinkle M K,Yun H C.History of infections associated with combat-related injuries[J].The Journal of Trauma:Injury,Infection,and Critical Care,2008,64:221-231.
[19] Valentine K P,Viacheslav K M.Bacterial flora of combat wounds from eastern Ukraine and time-specified changes of bacterial recovery during treatment in Ukrainian military hospital[J].BMC Research Notes,2017,10(1):152.
[20] Zhang H,Lv X,Zhang X,et al.Antibacterial and hemostatic performance of chitosan-organic rectorite/alginate composite sponge[J].RSC Advances,2015,5(62):5523-5531.
[21] Soleimani M,Habibi-Pirkoohi M.Biosynthesis of silver nanoparticles using chlorella vulgaris and evaluation of the antibacterial efficacy against staphylococcus aureus[J].Avicenna Journal of Medical Biotechnology,2017,9(3):120-125.
[22] Beattie M,Taylor J.Silver alloy vs.uncoated urinary catheters:a systematic review of the literature[J].Journal of Clinical Nursing,2011,20(15):2098-2108.
[23] Bartlett T R,Sokolov S V,Plowman B J,et al.Tracking of photochemical ostwald ripening of nanoparticles through voltammetric atom counting[J].Nanoscale,2016,8(36):16177-16181.
[24] Kharissova O V,Dias H V,Kharisov B I,et al.The greener synthesis of nanoparticles[J].Trends Biotechnol,2013,31(4):240-248.
[25] Basuny M,Ali I O,El-Gawad A A,et al.A fast green synthesis of Ag nanoparticles in carboxymethyl cellulose (CMC) through UV irradiation technique for antibacterial applications[J].Journal of Sol-Gel Science and Technology,2015,75(3):530-540.
[26] 王春来,关静,田丰.海藻酸钠光化学还原法制备纳米银[J].材料导报,2015,29(16):36-39.
[27] Soleimani M,Habibi-Pirkoohi M.Biosynthesis of silver nanoparticles using chlorella vulgaris and evaluation of the antibacterial efficacy against staphylococcus aureus[J].Avicenna Journal of Medical Biotechnology,2017,9(3):120-125.
[28] 陈煜,郑永发,邵立伟,等.天然抗菌剂茶树油在医用敷料中的应用研究[J].化工新型材料,2013,41(12):179-180.
[29] Macdonald M H,Wang A Y,Clymer J,et al.An in vivo comparison of the efficacy of hemostatic powders,using two porcine bleeding models[J].Medical Devices:Evidence and Research,2017,10:273-279.
[30] Fathi P,Sikoraki M,Christodoulides K,et al.Zeolite-loaded alginate-chitosan hydrogel beads as a topical hemostat[J].Journal of Biomedical Materials Research Part B:Applied Biomaterials,2018,106(5):1662-1671.
[31] Trabattoni D,Gatto P,Bartorelli A L.A new kaolin-based hemostatic bandage use after coronary diagnostic and interventional procedures[J].International Journal of Cardiology,2012,156(1):53-54.
[32] Li Y,Liao X,Zhang X,et al.In situ generated thrombin in the protein corona of zeolites:relevance of the functional proteins to its biological impact[J].Nano Research,2014,7(10):1457-1465.
[33] Rhee P,Brown C,Martin M,et al.QuikClot use in trauma for hemorrhage control:case series of 103 documented uses[J].The Journal of Trauma:Injury,Infection,and Critical Care,2008,64(4):1093-1099.
[34] Meddahi-Pelle A,Legrand A,Marcellan A,et al.Organ repair,hemostasis,and in vivo bonding of medical devices by aqueous solutions of nanoparticles[J].Angewandte Chemie International Edition,2014,53(25):6369-6373.
[35] Hong H,Wang C,Yuan Y,et al.Novel porous silica granules for instant hemostasis[J].RSC Advances,2016,6(82):7893-78935.
[36] Chen Z,Li F,Liu C,et al.Blood clot initiation by mesoporous silica nanoparticles:dependence on pore size or particle size?[J].Journal of Materials Chemistry B,2016,4(44):7146-7154.
[37] Li D,Nie W,Chen L,et al.Fabrication of curcumin-loaded mesoporous silica incorporated polyvinyl pyrrolidone nanofibers for rapid hemostasis and antibacterial treatment[J].RSC Advances,2017,7(13):7973-7982.
[38] di Lena F.Hemostatic polymers:the concept,state of the art and perspectives[J].Journal of Materials Chemistry B,2014,2(23):3567-3577.
[39] Hickman D A,Pawlowski C L,Sekhon U D S,et al.Biomaterials and advanced technologies for hemostatic management of bleeding[J].Advanced Materials,2018,30(4):1700859.
[40] 何贵东,李政,华嘉川,等.水凝胶在医学领域应用研究进展[J].化工新型材料,2017,45(5):223-225.
[41] Cheng F,Liu C,Wei X,et al.Preparation and characterization of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanocrystal/alginate biodegradable composite dressing for hemostasis applications[J].ACS Sustainable Chemistry & Engineering,2017,5(5):3819-3828.
[42] Pan M,Tang Z,Tu J,et al.Porous chitosan microspheres containing zinc ion for enhanced thrombosis and hemostasis[J].Materials Science and Engineering:C,2018,85:27-36.
[43] Wang C,Luo W,Li P,et al.Preparation and evaluation of chitosan/alginate porous microspheres/bletilla striata polysaccharide composite hemostatic sponges[J].Carbohydrate Polymers,2017,174:432-442.
[44] Seon G M,Lee M H,Kwon B,et al.Functional improvement of hemostatic dressing by addition of recombinant batroxobin[J].Acta Biomaterialia,2017,48:175-185.
[45] Lan G,Lu B,Wang T,et al.Chitosan/gelatin composite sponge is an absorbable surgical hemostatic agent[J].Colloids and Surfaces B:Biointerfaces,2015,136:1026-1034.
[46] Cheng W,Li H,Zheng X,et al.Processing,characterization and hemostatic mechanism of a ultraporous collagen/ORC biodegradable composite with excellent biological effectiveness[J].Physical Chemistry Chemical Physics,2016,18(42):29183-29191.
[47] Shamloo A,Sarmadi M,Aghababaie Z,et al.Accelerated full-thickness wound healing via sustained bFGF delivery based on a PVA/chitosan/gelatin hydrogel incorporating PCL microspheres[J].International Journal of Pharmaceutics,2018,537(2):278-289.
[48] Yan C,Yang T,Zhu S,et al.Synthesis and properties of poly(DEX-GMA/AAc) microgel particle as a hemostatic agent[J].Journal of Materials Chemistry B,2017,5(20):3697-3705.
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