采用水热合成法制备了SBA-15和SBA-16两种介孔SiO2载体材料,利用浸渍法将盐酸小檗碱(BBH)原料药负载于载体上,制备了载药BBH/SBA-15和BBH/SBA-16。通过多种表征方法对载药后材料的晶体结构、孔道结构等进行了测试,并研究了材料的载药、释药规律。结果表明,SBA-15和SBA-16的载药量分别为13.50%和3.45%。与BBH原料药相比,两种介孔SiO2载体均能够延长药物的释放,具有缓释效果。但SBA-15的孔径(5.77nm)较大,释药存在突释现象;而SBA-16的孔径(3.95nm)较小,能够缓慢释放药物。
Two kinds of mesoporous silica(SiO2) carriers,SBA-15 and SBA-16,were prepared by hydrothermal method,and berberine hydrochloride (BBH) as substance was loaded on the two carriers by dipping method to prepare BBH/SBA-15 and BBH/SBA-16.The crystal structure,pore structure of drug loaded mesoporous SiO2 carriers were investigated by several tests.The drug loading and release mechanism of the carriers were also studied.The results showed that the drug loading of SBA-15 and SBA-16 were 13.50% and 3.45%,respectively.Compared with BBH,two kinds of SiO2 carriers could extend the release of drugs,and had sustained release effect.The large pore size of SBA-15 (5.77nm) resulted in drug sudden release phenomenon,and the smaller pore size of SBA-16 (3.95nm) produced sustained release effect.
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