Lipophilic (LA) modified polyethylene glycol (PEG)(LA-PEG) was grafted to the surface of molybdenum disulfide (MoS2) to improve its biocompatibility,and further modified by graft polyethylenimine (PEI) which was used to link bovine serum albumin (BSA) modified folic acid (FA).Thus the drug delivery system FA-BSA-PEI-LA-MoS2-LA-PEG was constructed.The morphology and physicochemical properties of materials were characterized.The hydrodynamic size of materials was 133nm,which was suitable for using as a carrier of anticancer drugs.The drug loading efficiency and in vitro drug release behavior of complexes were investigated with DOX as model drug.The results showed that the cumulative drug release was 67.8% after 68h with NIR at pH 5.0.The drug delivery system had good drug-loading ability as well as application value.
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基金资助
上海市科学技术委员会资助项目(16410723700);生物医用纺织材料“111工程”中国教育部(B07024)
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